Nano Research, Journal Year: 2023, Volume and Issue: 17(2), P. 462 - 475
Published: July 1, 2023
Language: Английский
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472
Published: June 26, 2024
Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.
Language: Английский
Citations
33
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 206, P. 115199 - 115199
Published: Feb. 5, 2024
Ultrasound mediated drug delivery, a promising therapeutic modality, has evolved remarkably over the past three decades. Initially designed to enhance contrast in ultrasound imaging, microbubbles have emerged as main vector for offering targeted therapy with minimized side effects. This review addresses historical progression of this technology, emphasizing pivotal role play augmenting extravasation and delivery. We explore complex mechanisms behind from stable inertial cavitation diverse acoustic phenomena, their applications medical fields. While potential delivery is undeniable, there are still challenges overcome. Balancing efficacy safety establishing standardized procedures essential areas requiring attention. A multidisciplinary approach, gathering collaborations between researchers, engineers, clinicians, important exploiting full technology. In summary, highlights using improving patient care across various conditions.
Language: Английский
Citations
28
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)
Published: Jan. 4, 2024
Abstract The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent that regulates the transport various materials substances between blood vasculature central nervous (CNS). However, in cases brain diseases, BBB's protective regulatory effects hamper therapeutics from reaching affected sites sufficient quantities. This has so far been leading challenge treating CNS diseases disorders. For this problem to be overcome, recent research sought develop novel modalities achieve efficient therapy alleviate associated symptoms. Therefore, numerous strategies have operated years address limitations traditional invasive methods, including poor penetration serious side effects. As desperately in‐demand technology, nanotheranostics particularly shown promising results. Herein, review reports advancements techniques nanotechnology‐based developed for neurodegenerative study provides comprehensive data on subject used future studies management disorders diseases.
Language: Английский
Citations
24
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 15, 2024
Abstract Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers drugs. Gene therapy is specific can overcome the limitations traditional tissue engineering techniques has significant advantages in repair. However, therapeutic genes often affected by cellular barriers enzyme sensitivity, carrier loading essential. Therapeutic gene hydrogels well these difficulties. Moreover, gene-therapeutic have made considerable progress. This review summarizes recent research on treatment damage through summary most current frontiers. We initially introduce classification their cross-linking methods, followed detailed overview types modifications genes, discussion characterization features, design release, an applications engineering. Finally, we provide comments look forward to shortcomings future directions therapy. hope that this article will researchers related fields with more comprehensive systematic strategies repair further promote development field Graphical abstract
Language: Английский
Citations
17
The Innovation, Journal Year: 2023, Volume and Issue: 5(1), P. 100548 - 100548
Published: Nov. 27, 2023
•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.
Language: Английский
Citations
34
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1625 - 1625
Published: May 30, 2023
Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. can be engineered through bioconjugation of ligand, drug and/or cell. Since their inception few decades ago, several targeted microbubble (tMB) formulations have been developed as ultrasound imaging probes and ultrasound-responsive carriers to promote the local delivery uptake wide variety drugs, genes, cells in different therapeutic applications. The aim this review is summarize state-of-the-art current tMB ultrasound-targeted We provide an overview used increase loading capacity targeting strategies that enhance delivery, potentiate efficacy, minimize side effects. Additionally, future directions proposed improve performance diagnostic
Language: Английский
Citations
24
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)
Published: Jan. 11, 2024
Abstract Brain cancers, especially glioblastoma multiforme, are associated with poor prognosis due to the limited efficacy of current therapies. Nanomedicine has emerged as a versatile technology treat various diseases, including and played an indispensable role in combatting COVID‐19 pandemic evidenced by that lipid nanocarrier‐based vaccines have played. The tunability nanocarrier physicochemical properties —including size, shape, surface chemistry, drug release kinetics— resulted development wide range nanocarriers for brain cancer treatment. These can improve pharmacokinetics drugs, increase blood‐brain barrier transfer efficiency, specifically target cells. unique features would potentially allow more efficient treatment fewer side effects better therapeutic outcomes. This review provides overview options, challenges latest advances nanomedicine strategies investigated emphasis on targeted stimulus‐responsive their potential clinical translation.
Language: Английский
Citations
15
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 208, P. 115274 - 115274
Published: March 6, 2024
Ultrasound enhances drug delivery into the central nervous system (CNS) by opening barriers between blood and CNS triggering release of drugs from carriers. A key challenge in translating setups vitro to vivo settings is achieving equivalent acoustic energy delivery. Multiple devices have now been demonstrated focus ultrasound brain, with concepts emerging also target spinal cord. Clinical trials date used facilitate blood–brain barrier. While most focused on feasibility safety considerations, therapeutic benefits are beginning emerge. To advance translation these technologies for applications, researchers should standardise exposure protocol fine-tune parameters. Computational modelling be increasingly as a core component develop both delivering accurate reproducible CNS. This field holds promise transformative advancements management pharmacological treatment complex challenging disorders.
Language: Английский
Citations
13
Cancers, Journal Year: 2024, Volume and Issue: 16(1), P. 236 - 236
Published: Jan. 4, 2024
The blood–brain barrier (BBB) poses a significant challenge to drug delivery for brain tumors, with most chemotherapeutics having limited permeability into non-malignant tissue and only restricted access primary metastatic cancers. Consequently, due the drug’s inability effectively penetrate BBB, outcomes following chemotherapy continue be suboptimal. Several methods open BBB obtain higher concentrations in tumors have been proposed, selection of optimal method depending on size targeted tumor volume, chosen therapeutic agent, individual patient characteristics. Herein, we aim comprehensively describe osmotic disruption intra-arterial administration, intrathecal/intraventricular laser interstitial thermal therapy, convection-enhanced delivery, ultrasound methods, including high-intensity focused low-intensity as well tumor-treating fields. We explain scientific concept behind each method, preclinical/clinical research, advantages disadvantages, indications, potential avenues improvement. Given that has its limitations, it is unlikely future will rely single but rather synergistic effect combined approach. Disruption infusion or ultrasound, followed by drugs, promising Real-time monitoring necessary results.
Language: Английский
Citations
10
Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)
Published: Feb. 11, 2024
Abstract Current management of anesthesia‐associated complications falls short in terms both efficacy and safety. Nanomaterials with versatile properties unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination the existing nanotherapeutics highlights strategies developing prospective nanomedicines to mitigate anesthetics‐related toxicity. Initially, general, regional, local anesthesia along commonly used anesthetics related prevalent side effects are introduced. Furthermore, employing nanotechnology prevent alleviate is systematically demonstrated from three aspects, that is, 1) safe nano‐formulization anesthetics; 2) nano‐antidotes sequester overdosed alter their pharmacokinetics; 3) pharmacodynamic activities treat Finally, prospects challenges facing clinical translation anesthesia‐related discussed. work provides comprehensive roadmap effective toxicity, which can potentially revolutionize
Language: Английский
Citations
9