International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11669 - 11669
Published: Oct. 28, 2021
As
a
multifactorial
disease,
treatment
of
cancer
depends
on
understanding
unique
mechanisms
involved
in
its
progression.
The
stem
cells
(CSCs)
are
responsible
for
tumor
stemness
and
by
enhancing
colony
formation,
proliferation
as
well
metastasis,
these
can
also
mediate
resistance
to
therapy.
Furthermore,
the
presence
CSCs
leads
recurrence
therefore
their
complete
eradication
have
immense
therapeutic
benefits.
present
review
focuses
targeting
natural
products
growth
formation
capacities
been
reported
be
attenuated
dietary
agents.
These
compounds
induce
apoptosis
reduce
migration
invasion
via
EMT
inhibition.
A
variety
molecular
pathways
including
STAT3,
Wnt/β-catenin,
Sonic
Hedgehog,
Gli1
NF-κB
undergo
down-regulation
agents
suppressing
CSC
features.
Upon
exposure
agents,
significant
decrease
occurs
levels
markers
CD44,
CD133,
ALDH1,
Oct4
Nanog
impair
stemness.
suppression
enhance
sensitivity
tumors
chemotherapy
radiotherapy.
In
addition
vitro
studies,
experiments
different
preclinical
models
shown
capacity
use
nanostructures
improving
impact
is
recommended
rapidly
translate
findings
clinical
use.
Molecular and Cellular Biochemistry,
Journal Year:
2024,
Volume and Issue:
479(12), P. 3255 - 3271
Published: Feb. 29, 2024
Hypertension
is
a
major
harbinger
of
cardiovascular
morbidity
and
mortality.
It
predisposes
to
higher
rates
myocardial
infarction,
chronic
kidney
failure,
stroke,
heart
failure
than
most
other
risk
factors.
By
2025,
the
prevalence
hypertension
projected
reach
1.5
billion
people.
The
pathophysiology
this
disease
multifaceted,
as
it
involves
nitric
oxide
endothelin
dysregulation,
reactive
oxygen
species,
vascular
smooth
muscle
proliferation,
vessel
wall
calcification,
among
others.
With
advent
new
biomolecular
techniques,
various
studies
have
elucidated
gaping
hole
in
etiology
mechanisms
hypertension.
Indeed,
epigenetics,
DNA
methylation,
histone
modification,
microRNA-mediated
translational
silencing
appear
play
crucial
roles
altering
molecular
phenotype
into
hypertensive
profile.
Here,
we
critically
review
experimentally
determined
associations
between
microRNA
(miRNA)
molecules
pharmacotherapy.
Particular
attention
given
epigenetic
underlying
physiological
responses
antihypertensive
drugs
like
candesartan,
relevant
clopidogrel,
aspirin,
statins
Furthermore,
how
miRNA
affects
pharmaco-epigenetics
especially
highlighted.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11669 - 11669
Published: Oct. 28, 2021
As
a
multifactorial
disease,
treatment
of
cancer
depends
on
understanding
unique
mechanisms
involved
in
its
progression.
The
stem
cells
(CSCs)
are
responsible
for
tumor
stemness
and
by
enhancing
colony
formation,
proliferation
as
well
metastasis,
these
can
also
mediate
resistance
to
therapy.
Furthermore,
the
presence
CSCs
leads
recurrence
therefore
their
complete
eradication
have
immense
therapeutic
benefits.
present
review
focuses
targeting
natural
products
growth
formation
capacities
been
reported
be
attenuated
dietary
agents.
These
compounds
induce
apoptosis
reduce
migration
invasion
via
EMT
inhibition.
A
variety
molecular
pathways
including
STAT3,
Wnt/β-catenin,
Sonic
Hedgehog,
Gli1
NF-κB
undergo
down-regulation
agents
suppressing
CSC
features.
Upon
exposure
agents,
significant
decrease
occurs
levels
markers
CD44,
CD133,
ALDH1,
Oct4
Nanog
impair
stemness.
suppression
enhance
sensitivity
tumors
chemotherapy
radiotherapy.
In
addition
vitro
studies,
experiments
different
preclinical
models
shown
capacity
use
nanostructures
improving
impact
is
recommended
rapidly
translate
findings
clinical
use.
