Current Pharmaceutical Biotechnology,
Journal Year:
2023,
Volume and Issue:
25(8), P. 937 - 943
Published: Sept. 6, 2023
Parkinson's
disease
(PD)
is
a
widespread
neurodegenerative
disorder
that
exerts
broad
variety
of
detrimental
effects
on
people's
health.
Accumulating
evidence
suggests
mitochondrial
dysfunction,
neuroinflammation,
α-synuclein
aggregation
and
autophagy
dysfunction
may
all
play
role
in
the
development
PD.
However,
molecular
mechanisms
behind
these
pathophysiological
processes
remain
unknown.
Currently,
research
PD
has
focussed
high
mobility
group
box
1
(HMGB1),
different
laboratory
approaches
have
shown
promising
outcomes
to
some
level
for
blocking
HMGB1.
Given
HMGB1
regulates
participates
modulates
apoptosis,
it
hypothesised
significance
onset
In
current
review,
targeting
multiple
roles
pathology
was
integrated,
issues
need
future
attention
targeted
therapeutic
are
mentioned.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 28, 2023
Pulmonary
hypertension
(PH)
is
a
progressive,
pulmonary
vascular
disease
with
high
morbidity
and
mortality.
Unfortunately,
the
pathogenesis
of
PH
complex
remains
unclear.
Existing
studies
have
suggested
that
inflammatory
factors
are
key
in
PH.
Interleukin-6
(IL-6)
multifunctional
cytokine
plays
crucial
role
regulation
immune
system.
Current
reveal
IL-6
elevated
serum
patients
it
negatively
correlated
lung
function
those
patients.
Since
one
most
important
mediators
inflammation
PH,
signaling
mechanisms
targeting
may
become
therapeutic
targets
for
this
disease.
In
review,
we
detailed
potential
accelerating
process
specific
pathways.
We
also
summarized
current
drugs
these
pathways
to
treat
hope
study
will
provide
more
theoretical
basis
targeted
treatment
future.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 15, 2023
Since
the
first
70
years
of
reporting
cancer
chemotherapy,
malignant
tumors
have
been
second
most
common
cause
death
in
children
and
adults.
Currently,
commonly
used
anti-cancer
methods
include
surgery,
radiotherapy,
immunotherapy.
Although
these
treatment
could
alleviate
cancer,
they
lead
to
different
forms
side
effects
no
particularly
significant
effect
on
prolonging
patients’
life
span.
Glycyrrhizic
acid
(GL),
a
native
Chinese
herbal
extract,
has
wide
range
pharmacological
effects,
such
as
anti-cancer,
anti-inflammatory,
antioxidant,
immune
regulation.
In
this
review,
mechanisms
GL
are
summarized
various
cancers.
The
inhibition
chemotherapy-induced
including
hepatotoxicity,
nephrotoxicity,
genotoxicity,
neurotoxicity
pulmonary
toxicity,
is
highlighted.
Therefore,
may
be
promising
ideal
drug
for
therapy.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
For
patients
with
epilepsy,
antiseizure
medication
remains
the
primary
treatment;
however,
it
is
ineffective
in
approximately
30%
of
cases.
These
experience
progressive
neuronal
damage
and
poor
outcomes.
Therefore,
there
an
urgent
need
for
disease-modifying
therapy
(DMT)
that
targets
pathogenesis
epilepsy.
Glycyrrhizin
has
shown
potential
as
a
DMT
epilepsy
due
to
its
multiple
diverse
mechanisms.
Previous
studies
suggest
glycyrrhizin
may
regulate
key
processes
involved
pathogenesis,
such
neuroinflammation
cell
death,
but
effects
on
pyroptosis
have
not
been
reported.
This
study
employed
bioinformatics
techniques
identify
molecular
treatment
then
validated
using
kainic
acid-induced
status
epilepticus
mouse
model.
significantly
prolonged
seizure
latency,
reduced
duration,
alleviated
Molecular
experiments
indicated
through
mediation
high
mobility
group
box
1
(HMGB1)/Toll-like
receptor
4
(TLR4)/nuclear
factor
kappa-B
(NF-κB)
signaling
pathway.
exerts
neuroprotective
anticonvulsant
by
regulating
via
HMGB1/TLR4/NF-κB
pathway,
offering
novel
insights
into
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 9, 2025
Brain
microvascular
endothelial
cells
are
connected
by
tight
junction
(TJ)
proteins
and
interacted
adhesion
molecules,
which
participate
in
the
selective
permeability
of
blood–brain
barrier
(BBB).
The
disruption
BBB
is
associated
with
progression
cerebral
diseases.
Pterostilbene
a
natural
compound
found
blueberries
grapes
wide
range
biological
activities,
including
anti-inflammatory,
antioxidant,
anti-diabetic
effects.
In
this
study,
we
investigated
protective
effects
pterostilbene
on
LPS-stimulated
mouse
brain
(bEnd.3)
underlying
mechanisms.
results
showed
that
effectively
upregulated
expressions
such
as
zonula
occludens
(ZO)-1
claudin-5
downregulated
expression
molecules
intercellular
molecule
(ICAM)-1
vascular
cell
(VCAM)-1,
preventing
damage
under
LPS
stimulation.
decreased
LPS-triggered
inducible
nitric
oxide
synthase
(iNOS)
cyclooxygenase
(COX)-2
well
levels
interleukin
(IL)-6,
tumor
necrosis
factor
(TNF)-α
(NO).
Meanwhile,
exerted
an
inhibitory
effect
nuclear
kappa
B
(NF-κB)
mitogen-activated
protein
kinase
(MAPK)
pathways
bEnd.3
upon
Additionally,
exhibited
antioxidant
activating
heme
oxygenase
1
(HO-1).
These
findings
indicated
protected
against
lipopolysaccharide
(LPS)-induced
inflammation,
oxidative
stress
(BBB)
cells.
Brain Research Bulletin,
Journal Year:
2025,
Volume and Issue:
unknown, P. 111253 - 111253
Published: Feb. 1, 2025
Neurodegenerative
diseases
(NDDs)
are
a
class
of
cognitive
and
motor
disorders
including
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
Amyotrophic
Lateral
Sclerosis
(ALS),
others.
They
caused
by
lesions
in
cells
tissues
the
central
nervous
system,
resulting
corresponding
dysfunctions
consequent
decline
functions.
Neural
extremely
vulnerable
to
oxidative
stress,
which
plays
critical
biological
roles
NDDs.
Aromatic
compounds
found
extensively
natural
plants
have
substantial
effects
anti-oxidative
stress
damage,
not
only
wide
range
research
applications
cosmetics,
foods,
etc.,
but
also
frequently
utilized
treatment
various
system
diseases.
This
review
summarizes
relevant
mechanisms
NDDs
(AD,
PD,
HD,
ALS)
reviews
aromatic
such
as
polyphenols,
terpenoids,
flavonoids
that
can
be
used
management
neurodegenerative
diseases,
well
their
specific
antioxidant
action.
will
serve
reference
for
future
experimental
studies
on
illnesses
while
offering
fresh
insights
into
clinical
therapy.
