The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Language: Английский

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Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107146 - 107146

Published: March 16, 2024

Patients with chronic kidney disease (CKD) often experience mild cognitive impairment and other neurocognitive disorders. Studies have shown that erythropoietin (EPO) its receptor neuroprotective effects in cell animal models of nervous system Recombinant human EPO (rHuEPO), commonly used to treat anemia CKD patients, could be a agent. In this systematic review, we aimed assess the published studies investigating benefits rHuEPO treatment individuals reduced function. We comprehensively searched Pubmed, Cochrane Library, Scopus, Web Science databases from 1990 2023. After selection, 24 were analyzed, considering study design, sample size, participant characteristics, intervention, main findings. The collective results these patients indicated enhances brain function, improves performance on neuropsychological tests, positively affects electroencephalography measurements. These findings suggest promising agent for managing CKD-related impairment.

Language: Английский

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Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

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Exploring the mechanism of Radix Bupleuri in the treatment of depression combined with SARS-CoV-2 infection through bioinformatics, network pharmacology, molecular docking, and molecular dynamic simulation

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 17, 2025

Language: Английский

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PKR Inhibition Prevents Neuroinflammation and Rescues Depressive-Like Behaviors via BDNF/TrkB Signaling

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 4, 2025

Language: Английский

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Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4676 - 4676

Published: April 25, 2024

UVB radiation is known to induce photodamage the skin, disrupt skin barrier, elicit cutaneous inflammation, and accelerate aging process. Agaricus blazei Murill (ABM) an edible medicinal nutritional fungus. One of its constituents, polysaccharide (ABP), has been reported exhibit antioxidant, anti-inflammatory, anti-tumor, immunomodulatory effects, which suggests potential effects that protect against photodamage. In this study, a UVB-induced HaCaT model was established investigate reparative ABP two constituents (A1 A2). Firstly, purified polysaccharides, A1 A2, were obtained by DEAE-52 cellulose column chromatography, their physical properties chemical structures studied. A2 exhibited network-like microstructure, with molecular weights 1.5 × 104 Da 6.5 Da, respectively. The on cell proliferation, mitochondrial membrane potential, inflammatory factors also explored. results show significantly promoted enhanced suppressed expression interleukin-1β (IL-1β), interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), increased relative content filaggrin (FLG) aquaporin-3 (AQP3). down-regulated JAK-STAT signaling pathway found play role in response These findings underscore ameliorate damage.

Language: Английский

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Danggui-Shaoyao San Alleviates Cognitive Impairment via Enhancing HIF-1α/EPO Axis in Vascular Dementia Rats

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118306 - 118306

Published: May 7, 2024

Language: Английский

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Efficacy and Safety of High-Dose Erythropoietin Combined with Hypothermia Therapy in Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review and Meta-Analysis

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111964 - 111964

Published: April 10, 2024

Language: Английский

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Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

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