Cell Division,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Nov. 28, 2024
Cervical
carcinoma
poses
a
significant
health
threat,
with
traditional
treatments
proving
inadequate
in
advanced
stages.
Curcumin,
bioactive
compound
derived
from
turmeric,
exhibits
notable
anti-inflammatory,
antioxidant,
and
antineoplastic
properties,
potentially
modulating
autophagy,
metastasis
cancer
cells.
This
study
examines
curcumin's
impact
on
autophagy
cervical
carcinoma,
focusing
its
interaction
autophagy-related
gene
3
(ATG3).
SiHa
HeLa
cell
lines
were
treated
curcumin,
ATG3
knockdown
(shATG3),
their
combination.
Cell
migration
was
evaluated
via
wound
healing
assays,
while
proliferation
CCK-8
assays.
LC3
expression
assessed
using
immunofluorescence
western
blotting.
Molecular
docking
simulations
identified
binding
interactions
key
proteins.
Curcumin
shATG3
significantly
inhibited
both
proliferation,
synergistic
effect
observed
when
combined.
enhanced,
indicating
increased
autophagy.
Docking
studies
revealed
potential
to
MMP2,
MMP9,
TGF-β,
ATG3,
LC3,
p62,
suggesting
modulation
of
these
pathways.
The
combination
curcumin
also
enhancing
supporting
the
as
therapeutic
agent
for
carcinoma.
Further
clinical
research
is
needed
validate
findings.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
277, P. 116343 - 116343
Published: April 23, 2024
Curcumin
(CUR)
is
a
compound
extracted
from
turmeric
that
has
variety
of
functions
including
antioxidant
and
anti-inflammatory.
As
an
estrogen-like
mycotoxin,
zearalenone
(ZEN)
not
only
attacks
the
reproductive
system,
but
also
toxic
effects
on
liver.
However,
whether
CUR
can
alleviate
ZEN-induced
liver
injury
remains
unclear.
This
paper
aims
to
investigate
protective
effect
against
in
mice
explore
molecular
mechanism
involved.
BALB/c
were
randomly
divided
into
control
(CON)
group,
group
(200
mg/kg
b.
w.
CUR),
ZEN
(40
ZEN)
CUR+ZEN
CUR+40
ZEN).
28
d
after
exposure
treatment,
blood
samples
collected
for
subsequent
testing.
The
results
showed
reversed
hepatocyte
swelling
necrosis
mice.
It
significantly
reduced
serum
alkaline
phosphatase
(ALP),
alanine
aminotransferase
(ALT)
aspartate
(AST)
levels
(p
<
0.05).
In
addition,
hepatic
ROS,
malondialdehyde,
hydrogen
peroxide
apoptosis
Quantitative
RT-PCR
Western
blot
expression
Bax
Caspase3,
increase
Nrf2,
HO-1
NQO1
induced
by
conclusion,
alleviated
scavenging
ROS
inhibiting
mitochondrial
apoptotic
pathway.
Brain Injury,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: April 21, 2025
TBI's
intricate
pathophysiology,
which
includes
oxidative
stress,
neuroinflammation,
apoptosis,
and
mechanical
injury,
makes
it
a
serious
public
health
concern.
Although
stabilization
secondary
damage
management
are
the
main
goals
of
current
treatments,
their
efficacy
is
still
restricted.
The
potential
for
improving
patient
outcomes
by
combining
phytochemicals
with
traditional
medicines
examined
in
this
review.
study
neuroprotective
qualities
ginsenosides,
ginkgolides,
resveratrol,
curcumin
as
well
antioxidant
anti-inflammatory
activities.
Analysis
was
done
on
molecular
pathways
medication
delivery
techniques
to
improve
translational
drug
availability
clinical
practice.
Phytochemical
substances
directly
influence
TBI-related
neurogenic
functional
restoration
while
also
affecting
subsequent
neural
processes.
Particle-based
medicine
platforms
enhance
therapeutic
efficacy,
emerging
innovative
solutions
targeted
delivery.
When
medical
therapies
integrate
phytochemicals,
becomes
possible
achieve
better
results
through
enhanced
synergy.
This
review
uniquely
integrates
standard
TBI
emphasizing
advanced
strategies
neuroprotection
outcomes.
Unlike
previous
studies,
explores
novel
platforms,
such
nanoparticle-based
systems,
highlights
synergy
between
conventional
recovery.
Foods,
Journal Year:
2024,
Volume and Issue:
13(4), P. 549 - 549
Published: Feb. 10, 2024
Dextranase
(EC
3.2.1.11)
is
primarily
applied
in
food,
sugar,
and
pharmaceutical
industries.
This
study
focuses
on
using
a
cold
shock
Escherichia
coli
expression
system
to
express
marine
dextranase
SP5-Badex;
enzyme
activity
increased
about
2.2-fold
compared
previous
expression.
was
employed
produce
sweet
potato
porous
starch,
with
special
emphasis
the
pore
size
of
starch.
The
water
oil
adsorption
rates
starch
by
1.43
1.51
times,
respectively.
Extensive
Fourier
transform
infrared
spectroscopy
X-ray
diffraction
revealed
that
crystal
structure
unaltered
enzymatic
hydrolysis.
capacities
for
curcumin
proanthocyanidins
were
9.59
12.29
mg/g,
Notably,
stability
significantly
enhanced
through
their
encapsulation
After
2.5
h
ultraviolet
irradiation,
free
radical
scavenging
rate
encapsulated
remained
at
95.10%.
Additionally,
after
30
days
sunlight
exposure,
(84.42%)
higher
than
(24.34%)
observed
control
group.
These
research
findings
provide
substantial
experimental
evidence
preparing
dextranase.
