Psychiatric Annals, Journal Year: 2024, Volume and Issue: 54(8)
Published: Aug. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 23, 2024
Abstract Alzheimer’s disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. Its etiology is intricate diverse, stemming from a combination factors such aging, genetics, environment. Our current understanding AD pathologies involves various hypotheses, cholinergic, amyloid, tau protein, inflammatory, oxidative stress, metal ion, glutamate excitotoxicity, microbiota-gut-brain axis, abnormal autophagy. Nonetheless, unraveling interplay among these pathological aspects pinpointing primary initiators require further elucidation validation. In past decades, most clinical drugs have been discontinued due to limited effectiveness or adverse effects. Presently, available primarily offer symptomatic relief often accompanied by undesirable side However, recent approvals aducanumab ( 1 ) lecanemab 2 Food Drug Administration (FDA) present potential in disrease-modifying Nevertheless, long-term efficacy safety need Consequently, quest for safer more effective persists formidable pressing task. This review discusses pathogenesis, advances diagnostic biomarkers, latest updates trials, emerging technologies drug development. We highlight progress discovery selective inhibitors, dual-target allosteric modulators, covalent proteolysis-targeting chimeras (PROTACs), protein-protein interaction (PPI) modulators. goal provide insights into prospective development application novel drugs.
Language: Английский
Citations
135
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102659 - 102659
Published: Jan. 10, 2025
Language: Английский
Citations
2
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102664 - 102664
Published: Jan. 1, 2025
Language: Английский
Citations
1
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing repair regeneration bone defects. Numerous characteristics should be noticed repair, such as irregular morphology defects, homeostasis between hosts microorganisms cavity complex periodontal structures that facilitate epithelial ingrowth. Therefore, necessitates restoration materials adhere to stringent specific demands. This review starts exploring these particular requirements by introducing bones then summarizes classifications current respect composition structure. Additionally, we discuss modifications including improving mechanical properties, optimizing surface topography pore adding bioactive components elements, compounds, cells their derivatives. Ultimately, organize a range potential optimization strategies future perspectives for enhancing materials, physical environment manipulation, microbial modulation, osteo-immune regulation, smart stimuli-responsive multifaceted approach poly-pathic treatment, hope providing some insights researchers this field. In summary, analyzes demands especially alveolar bone, concludes corresponding biomaterials aims inspire research pursuit more effective treatment outcomes.
Language: Английский
Citations
6
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Aug. 21, 2024
Introduction Alzheimer’s disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy physical exercise as non-pharmacological intervention to mitigate impacts AD. Methods draws on recent studies that investigate effects neuroinflammation neuronal enhancement in individuals with Results Consistent alters neuroinflammatory pathways, enhances cognitive functions, bolsters brain health among AD patients. It favorably influences activation states microglia astrocytes, fortifies integrity blood-brain barrier, attenuates gut inflammation associated These changes are substantial improvements performance indicators. Discussion The findings underscore potential integrating into comprehensive management strategies. Emphasizing necessity for further research, this advocates refinement regimens maximize their enduring benefits decelerating progression
Language: Английский
Citations
5
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 4, 2024
Alzheimer's Disease (AD) is increasingly recognized as being associated with metabolic disorders, including Metabolic Associated Steatotic Liver (MASLD). This study aimed to assess the relative risk of AD in individuals MASLD.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11272 - 11272
Published: Oct. 19, 2024
Recent studies underscore the role of gut and oral microbiota in influencing neuroinflammation through microbiota–gut–brain axis, including Alzheimer’s disease (AD). This review aims to provide a comprehensive synthesis recent findings on involvement neuroinflammatory processes associated with AD, emphasizing novel insights therapeutic implications. reveals that dysbiosis AD patients’ is linked heightened peripheral central inflammatory responses. Specific bacterial taxa, such as Bacteroides Firmicutes gut, well Porphyromonas gingivalis cavity, are notably altered leading significant changes microglial activation cytokine production. Gut alterations increased intestinal permeability, facilitating translocation endotoxins like lipopolysaccharides (LPS) into bloodstream exacerbating by activating brain’s toll-like receptor 4 (TLR4) pathways. Furthermore, microbiota-derived metabolites, short-chain fatty acids (SCFAs) amyloid peptides, can cross blood-brain barrier modulate While microbial amyloids may contribute amyloid-beta aggregation brain, certain SCFAs butyrate exhibit anti-inflammatory properties, suggesting potential avenue mitigate neuroinflammation. not only highlights critical pathology but also offers ray hope modulating could represent strategy for reducing slowing progression.
Language: Английский
Citations
4
Geriatrics, Journal Year: 2025, Volume and Issue: 10(2), P. 37 - 37
Published: March 7, 2025
Background/Objectives: Alzheimer’s disease (AD) is the most common form of dementia, characterized by an irreversible decline in cognitive function. The pathogenesis several neurodegenerative disorders has been linked to changes gut microbiota, transmitted through gut-brain axis. Methods: We set out establish case-control study methodology whether there were any differences composition and/or function microbiota between older resident adults care homes with or without AD diagnosis via analysis microbial from fecal samples. Results: composition, determined 16S rRNA gene profiling, indicated that sufferers had significantly increased proportions Escherichia/Shigella and Clostridium_sensu_stricto_1, decreased Bacteroides, Faecalibacterium, Blautia, Roseburia species. increase potentially pro-inflammatory bacteria was consistent slightly higher concentrations calprotectin, a biomarker inflammation. Fecal metabolites measured similar across groups, although participants branched-chain fatty acid, iso-butyrate, lower overall total short chain acids. Conclusions: Participants have key within their profile, contrast home residents disease. altered microbiome included both compositional functional poorer health
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 8, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0