Tumor-targeting Nanomaterials Based on Metal-organic Frameworks Mediate Tumor Immunotherapy by Promoting Cuproptosis and Pyroptosis in Hepatocellular Carcinoma Cells DOI Creative Commons

Xiaoyuan Yi,

Huaying Xie,

Kunzhao Huang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101745 - 101745

Published: April 1, 2025

Language: Английский

Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics DOI Creative Commons
Liqiang Zhou, Yangmengfan Chen, Dong Xie

et al.

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Language: Английский

Citations

20

Melanoma biology and treatment: a review of novel regulated cell death-based approaches DOI Creative Commons

Ming-yun Hsieh,

Sheng‐Kai Hsu,

Tzu‐Yu Liu

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 9, 2024

Abstract The incidence of melanoma, the most lethal form skin cancer, has increased due to ultraviolet exposure. treatment advanced particularly metastatic cases, remains challenging with poor outcomes. Targeted therapies involving BRAF/MEK inhibitors and immunotherapy based on anti-PD1/anti-CTLA4 antibodies have achieved long-term survival rates approximately 50% for patients melanoma. However, therapy resistance inadequate response continue hinder further breakthroughs in treatments that increase rates. This review provides an introduction molecular-level pathogenesis melanoma offers overview current options their limitations. Cells can die by either accidental or regulated cell death (RCD). RCD is orderly controlled a variety macromolecules maintain stability internal environment. Since uncontrolled proliferation tumor cells requires evasion programs, inducing may be strategy. summarizes studies various types nonapoptotic RCDs, such as autophagy-dependent death, necroptosis, ferroptosis, pyroptosis, recently discovered cuproptosis, context relationships between these RCDs are examined, interplay targeted discussed. Given findings demonstrating different stimuli associated induction shows promise integral component strategies

Language: Английский

Citations

14

Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases DOI
Zhibo Yang,

Ridong Feng,

Zhao Hai

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(9-10), P. 1330 - 1360

Published: July 16, 2024

Language: Английский

Citations

12

Targeting cell death in NAFLD: mechanisms and targeted therapies DOI Creative Commons

Huili Xu,

Shengrong Wan,

Ying An

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 7, 2024

Language: Английский

Citations

11

Copper's dual role: Reviewing its impact on liver health and disease DOI
Tongtong Pan, Jiayin Huang, Xiaodong Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114391 - 114391

Published: March 12, 2025

Language: Английский

Citations

2

Knocking Down Ferredoxin 1 Inhibits the Progression of Colorectal Cancer and Regulates Cuproptosis via Mediating the Hippo Signaling Pathway DOI Open Access
Ying Hu, Haihua Liu,

Xiaobin Tan

et al.

Molecular Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

ABSTRACT Cuproptosis is a form of programmed cell death dependent on mitochondrial respiration and crucial in cancer treatment. The study attempted to screen cuproptosis‐associated genes colorectal (CRC) reveal regulatory pathways. Weighted gene co‐expression network analysis (WGCNA) was applied the modules based expression CRC patients. were screened at intersection cuproptosis data set. RNA sequencing performed assess transcriptome changes, followed by functional enrichment analyses potential Ferredoxin 1 (FDX1) knocked down vivo vitro experiments investigate effects FDX1 knockdown progression cuproptosis. found as highly expressed tumor cells. Knockdown regulated cells, inhibited growth, migration invasion. We 1956 upregulated DEGs 2201 downregulated si‐FDX1 which mainly enriched mitogen‐activated protein kinase (MAPK) signaling pathway, necrosis factor (TNF) pathway Hippo pathway. increasing levels dihydrolipoamide S‐succinyltransferase (DLST), lipoic acid synthetase (LIAS) phosphorylation Yes‐associated (pYAP)/YAP, transcriptional coactivator with PDZ‐binding domain (TAZ). inhibitor GA‐017 blocked this process. Knocking mediating shed new insights into development biomarkers for

Language: Английский

Citations

1

Robust Cu2+-Modified Black Phosphorus Nanoplatform for Enhanced Drug Delivery and Synergistic Multimodal Tumor Therapy via Metal Ion-Assisted π–π Interactions DOI
Kai Ling,

Jianlan Bu,

Weijie Huang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The application of 2D nanomaterials for drug delivery via π-π interactions has been extensively investigated. However, these often lack robustness in the presence blood proteins due to competitive binding proteins, which results from strong π-π-stacking with aromatic protein residues. This can lead premature release and diminished therapeutic efficacy. To address this challenge, we developed a robust delivery/therapeutic biomimetic nanoplatform that enhances adsorption affinity targeted efficiency chemotherapeutic doxorubicin (DOX) by utilizing Cu2+-modified black phosphorus nanosheets (BP@Cu2+) through metal ion-assisted interactions. synergistic between π-electrons BP DOX, mediated Cu2+ coordination, form stable sandwiched π-cation-π stacking complex (BP@Cu2+/DOX). metal-ion-bridged architecture significantly DOX loading capacity minimizes serum. In acidic tumor microenvironment, interaction is disrupted, enabling controlled both ions. Furthermore, encapsulation within cell membranes targeting, resulting (BP@Cu2+/DOX-CMs). Combined near-infrared laser irradiation, achieves multimodal therapy integrating phototherapy, chemotherapy, chemodynamic therapy, cuproptosis enhance antitumor study highlights potential development advanced nanoplatforms, thereby paving way innovative biomedical applications conventional nanomaterials.

Language: Английский

Citations

1

The Regulation of Trace Metal Elements in Cancer Ferroptosis DOI Creative Commons

Xiaoyan Wang,

Yuanyuan Xue, Lei Chang

et al.

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Language: Английский

Citations

1

Copper homeostasis and cuproptosis in health and disease DOI Creative Commons

Yunuo Yang,

Jiaxuan Wu,

Lisheng Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 17, 2024

Copper is a vital trace element in human physiology, essential for the synthesis of numerous crucial metabolic enzymes and facilitation various biological processes. Regulation copper levels within narrow range imperative maintaining homeostasis. Numerous studies have demonstrated significant roles homeostasis cuproptosis health disease pathogenesis. However, comprehensive up-to-date systematic review this domain remains absent. This aims to consolidate recent advancements understanding disease, focusing on underlying mechanisms potential therapeutic interventions. Dysregulation homeostasis, manifesting as either excess or deficiency, implicated etiology diseases. Cuproptosis, recently identified form cell death, characterized by intracellular overload. phenomenon mediates diverse array evolutionary processes organisms, spanning from genetic disorders, liver diseases, neurodegenerative cancers. provides summary pathogenic along with associated targeted agents. Furthermore, it explores future research directions yield treatment, management, prevention.

Language: Английский

Citations

7

Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy DOI Creative Commons

Sai‐Nan Zhang,

Qibo Huang,

Tuo Ji

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 31, 2024

Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis critical human health, its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities metal ion regulation interact with fate. This review insights into the complex mechanisms metabolism, molecular basis cuproptosis, association cancer development. We assess role cuproptosis-related genes (CRGs) associated tumorigenesis, their importance prognostic indicators targets, impact on tumor microenvironment (TME) immune response. Ultimately, this highlights interplay between copper, immunotherapy.

Language: Английский

Citations

5