Experimental Gerontology,
Journal Year:
2023,
Volume and Issue:
181, P. 112269 - 112269
Published: Sept. 1, 2023
Ageing
alters
the
ECM,
leading
to
mitochondrial
dysfunction
and
oxidative
stress,
which
triggers
an
inflammatory
response
that
exacerbates
with
age.
Age-related
changes
impact
satellite
cells,
affecting
muscle
regeneration,
balance
of
proteins.
Furthermore,
ageing
causes
a
decline
in
NAD+
levels,
alterations
fat
metabolism
our
health.
These
various
metabolic
issues
become
intricately
intertwined
ageing,
variety
individual-level
diseases
profoundly
individuals'
healthspan.
Therefore,
we
hypothesize
vutiglabridin
capable
alleviating
these
abnormalities
will
be
able
ameliorate
many
problems
associated
ageing.The
efficacy
vutiglabridin,
alleviates
by
enhancing
function,
was
assessed
aged
mice
treated
compared
untreated
elderly
mice.
On
young
mice,
vutiglabridin-treated
non-treated
Senescence-associated
beta-galactosidase
staining
q-PCR
for
marker
genes
were
carried
out.
Bulk
RNA-seq
out
on
GA
muscle,
eWAT,
liver
from
each
group
compare
differences
gene
expression
pathways.
Blood
used
analyze
lipid
profile.SA-β-gal
liver,
kidney,
spleen
showed
had
anti-ageing
effects
control
group,
including
Cdkn1a
Cdkn2a
tissue
reduced
process.
In
improved
homeostasis
controls,
eWAT
restored
insulin
sensitivity
prevented
FALC-induced
inflammation,
inflammation
levels
due
TLO
formation,
complex
I
assembly,
resulting
ROS
formation.
blood
analysis
revealed
ageing-related
profile
relieved
versus
group.Vutiglabridin
slows
mechanisms
such
as
decreased
sensitivity,
increased
altered
adipose
experiments,
while
also
retaining
homeostasis,
is
deteriorated
It
improves
restores
function
reduce
generation.
Frontiers in Physiology,
Journal Year:
2021,
Volume and Issue:
12
Published: Nov. 23, 2021
Phospholipids
are
major
membrane
lipids
that
consist
of
lipid
bilayers.
This
basic
cellular
structure
acts
as
a
barrier
to
protect
the
cell
against
various
environmental
insults
and
more
importantly,
enables
multiple
processes
occur
in
subcellular
compartments.
Numerous
studies
have
linked
complexity
signal
transductions,
organelle
functions,
well
physiological
processes,
human
diseases.
Recently,
crucial
roles
for
aging
process
beginning
emerge.
In
this
study,
we
summarized
current
advances
our
understanding
relationship
between
with
an
emphasis
on
phospholipid
species.
We
surveyed
how
species
change
age
different
organisms
tissues,
some
common
patterns
during
were
proposed.
Further,
functions
molecules
regulating
healthspan
lifespan,
their
potential
mechanisms
action,
also
discussed.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4645 - 4645
Published: April 24, 2024
The
human
brain
possesses
three
predominate
phospholipids,
phosphatidylcholine
(PC),
phosphatidylethanolamine
(PE)
and
phosphatidylserine
(PS),
which
account
for
approximately
35–40%,
20%
of
the
brain’s
respectively.
Mitochondrial
membranes
are
relatively
diverse,
containing
aforementioned
PC,
PE,
PS,
as
well
phosphatidylinositol
(PI)
phosphatidic
acid
(PA);
however,
cardiolipin
(CL)
phosphatidylglycerol
(PG)
exclusively
present
in
mitochondrial
membranes.
These
phospholipid
interactions
play
an
essential
role
fusion
fission
dynamics,
leading
to
maintenance
structural
signaling
pathways.
nature
these
phospholipids
is
demonstrated
through
inability
mitochondria
tolerate
alteration
specific
with
changes
damage
resulting
neural
degeneration.
This
review
will
emphasize
how
structure
relates
their
physiologic
function,
metabolism
facilitates
signaling,
organ-
mitochondria-specific
compositions.
Finally,
we
discuss
effects
global
ischemia
reperfusion
on
alongside
novel
therapeutics
that
may
protect
against
injury.
Foods,
Journal Year:
2024,
Volume and Issue:
13(6), P. 969 - 969
Published: March 21, 2024
Silkie
chicken,
an
important
chicken
breed
with
high
medicinal
and
nutritional
value,
has
a
long
history
of
being
used
as
dietary
supplement
in
China.
However,
the
compounds
health-promoting
effects
chickens
remain
unclear.
In
present
study,
we
conducted
comprehensive
analysis
metabolic
lipidomic
profiles
to
identify
characteristic
bioactive
chickens,
using
common
control.
The
results
showed
that
levels
13
metabolites
including
estradiol,
four
lipid
subclasses
cardiolipin
(CL),
eight
molecules,
three
fatty
acids
docosahexaenoic
acid
(C22:6)
were
significantly
increased
which
have
physiological
activities
such
resisting
chronic
diseases
improving
cognition.
These
on
meat
quality
characteristics,
its
water-holding
capacity
umami
taste
increasing
content
aromatic
phenols.
differentially
expressed
genes
(DEGs)
between
two
breeds
revealed
regulatory
network
for
these
compounds.
Fifteen
DEGs,
HSD17B1,
are
involved
synthesis
metabolites.
Eleven
ELOVL2,
transport
lipids
acids.
summary,
identified
analyzed
their
characteristics.
This
study
provided
insight
into
functional
food.
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 792 - 792
Published: Feb. 26, 2025
The
mechanism
of
egg
yolk
phosphatidylcholine
(PC)
in
alleviating
Alzheimer's
disease
(AD)
has
not
yet
been
clear.
fatty
acid
composition
PC,
especially
the
ratio
polyunsaturated
acids
(PUFA),
may
be
a
critical
determinant
their
structural
and
functional
roles.
This
study
aimed
to
conduct
comparative
analysis
unsaturation
levels
PC
impact
on
neurological
health
murine
model
AD.
results
showed
that
oral
administration
high
low
(HUP,
LUP)
enhanced
learning
memory
abilities
AD
mice,
with
HUP
intervention
demonstrating
superior
efficacy
compared
LUP.
Follow-up
biochemical
brain
tissue
also
suggested
effectively
mitigated
oxidative-stress
damage
inhibited
tau
hyperphosphorylation
mice.
Meanwhile,
lipidomic
analyses
mouse
hippocampus
revealed
substantially
increased
phospholipids,
such
as
PEt
(phosphatidylethanol)
BisMePA
(bis(methylthio)phenylacetic
acid),
which
are
recognized
vital
components
neuronal
cell
membranes.
Furthermore,
markedly
elevated
phospholipids
incorporating
PUFAs
hippocampus.
These
mitigating
role
for
unsaturated
prevention
offer
new
insights
into
from
perspective.
