Nicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice DOI Creative Commons
Caifang Ren,

Zhang Shuang,

Jianyu Ma

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1028 - 1028

Published: Dec. 8, 2024

Polycystic ovary syndrome (PCOS) involves complex genetic, metabolic, endocrine, and environmental factors. This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation. Letrozole-induced aromatase inhibition elevated androgen reduced bile acid levels, linking liver dysfunction gut imbalance to PCOS. Letrozole-treated mice exhibited disrupted estrous cycles, ovarian congestion, testosterone. NMN intervention alleviated hyperandrogenism, abnormalities, decline but did not fully restore cycle or improve lipid profiles. Metabolomic analysis showed that partially reversed metabolism disturbances. These findings highlight NMN’s protective role reducing hyperandrogenism cyst formation. However, effective treatment should target metabolism, just symptoms, mitigate systemic effects. Bile dysregulation may play key progression warrants further investigation.

Language: Английский

Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies DOI Creative Commons
Ewelina Musielak, Violetta Krajka‐Kuźniak

Micro, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 3, 2025

Due to their biocompatibility, nontoxicity, and surface conjugation properties, nanomaterials are effective nanocarriers capable of encapsulating chemotherapeutic drugs facilitating targeted delivery across the blood–brain barrier (BBB). Although research on nanoparticles for brain cancer treatment is still in its early stages, these systems hold great potential revolutionize drug delivery. Glioblastoma multiforme (GBM) one most common lethal tumors, heterogeneous aggressive nature complicates current treatments, which primarily rely surgery. One significant obstacles poor penetration BBB. Moreover, GBM often referred as a “cold” tumor, characterized by an immunosuppressive tumor microenvironment (TME) minimal immune cell infiltration, limits effectiveness immunotherapies. Therefore, developing novel, more treatments critical improving survival rate patients. Current strategies enhancing outcomes focus controlled, agents cells BBB using nanoparticles. These therapies must be designed engage specialized transport systems, allowing efficient penetration, improved therapeutic efficacy, reduced systemic toxicity degradation. Lipid inorganic can enhance while minimizing side effects. formulations may include epitopes—small antigen fragments that bind directly free antibodies, B receptors, or T receptors—that interact with enable crossing, thereby boosting efficacy. Lipid-based (LNPs), such liposomes, niosomes, solid lipid (SLNs), nanostructured carriers (NLCs), among promising due unique including size, modification capabilities, proven biosafety. Additionally, gold nanoparticles, mesoporous silica, superparamagnetic iron oxide dendrimers offer alternatives. Inorganic (INPs) easily engineered, surfaces modified various elements biological ligands delivery, biocompatibility. Strategies engineering functionalization have been employed ensure biocompatibility reduce cytotoxicity, making safer clinical applications. The use INPs has shown promise efficacy traditional like chemotherapy, radiotherapy, gene therapy, well advancing newer strategies, immunotherapy, photothermal photodynamic therapies, magnetic hyperthermia. This article reviews latest treating GBM, focusing active passive targeting approaches.

Language: Английский

Citations

3
Rescue of hippocampal synaptic plasticity and memory performance by Fingolimod (FTY720) in APP/PS1 model of Alzheimer's disease is accompanied by correction in metabolism of sphingolipids, polyamines, and phospholipid saturation composition DOI Creative Commons
Karel Kalecký,

Luna Buitrago,

Juan Marcos Alarcón

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Abstract Previously, our metabolomic, transcriptomic, and genomic studies characterized the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease, we demonstrated that FTY720, sphingosine-1-phospahate receptor modulator approved for treatment of multiple sclerosis, recovers synaptic plasticity memory APP/PS1 mice. To further investigate how FTY720 rescues pathology, performed metabolomic analysis brain, plasma, liver trained wild-type mice showed area-specific brain disturbances polyamines, phospholipids, sphingolipids. Most changes were completely or partially normalized FTY720-treated subjects, indicating rebalancing “sphingolipid rheostat”, reactivating phosphatidylethanolamine synthesis via mitochondrial phosphatidylserine decarboxylase pathway, normalizing polyamine levels support activity. Synaptic rescued, with spermidine temporal cortex best corresponding to hippocampal CA3-CA1 normalization. effects, also reflected other pathways, are consistent promotion function, plasticity, anti-inflammatory environment, while reducing pro-apoptotic pro-inflammatory signals.

Language: Английский

Citations

0
Lipidomics Reveals Dietary Alpha Linolenic Acid Facilitates Metabolism Related to Division of Labor in Honeybee Workers DOI Creative Commons

Zeng Qing-xiao,

Dan Zong, Xiabing Li

et al.

Agriculture, Journal Year: 2025, Volume and Issue: 15(3), P. 272 - 272

Published: Jan. 27, 2025

The division of labor among honeybee workers contributes to efficient pollination activities. Lipids play a crucial role in behavioral regulation, with pollen serving as primary source these lipids. However, the regulatory effect lipids on remains be studied. In this study, an in-depth lipidomic analysis based HPLC-QTOF-MS and UPLC-IM-QTOF-MS was applied. We conducted first comprehensive profiling abdomen, brain, intestine emerging, nursing, foraging bees, well pollen, thereby establishing lipid library comprising 646 species. composition found exhibit characteristics similar those workers, alpha linolenic acid (ALA) validated key characteristic lipid. Moderate dietary ALA supplementation reshaped levels facilitated metabolism related division. These findings advance field revealing novel regulator extending understanding nutritional regulation workers.

Language: Английский

Citations

0
Glycerophospholipid and Sphingosine- 1-phosphate Metabolism in Cardiovascular Disease: Mechanisms and Therapeutic Potential DOI
Huiru Tang,

Chengxia Kan,

Kexin Zhang

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0
Exploring Innovative Approaches for Managing Spinal Cord Injury: A Comprehensive Review of Promising Probiotics and Postbiotics DOI

Fereshteh Jamali,

Safa Mousavi, Aziz Homayouni Rad

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

Citations

0
Nitric oxide maintains mitochondrial function by regulating mitochondrial membrane lipid metabolism DOI
Yue Wang,

Maogang Chen,

Jiangtao You

et al.

Postharvest Biology and Technology, Journal Year: 2025, Volume and Issue: 227, P. 113574 - 113574

Published: April 17, 2025

Language: Английский

Citations

0
The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity DOI Creative Commons

Leah E. Jamerson,

Patrick C. Bradshaw

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 820 - 820

Published: July 8, 2024

Dietary restriction (DR) protocols frequently employ intermittent fasting. Following a period of fasting, meal consumption increases lipogenic gene expression, including that NADPH-generating enzymes fuel lipogenesis in white adipose tissue (WAT) through the induction transcriptional regulators SREBP-1c and CHREBP. knockout mice, unlike controls, did not show an extended lifespan on DR diet. WAT cytoplasmic NADPH is generated by both malic enzyme 1 (ME1) pentose phosphate pathway (PPP), while liver primarily synthesized folate cycle provided one-carbon units serine catabolism. During daily fasting diet, fatty acids are released from transported to peripheral tissues, where they used for beta-oxidation phospholipid lipid droplet synthesis, monounsaturated (MUFAs) may activate Nrf1 inhibit ferroptosis promote longevity. Decreased PPP stimulated browning protected high-fat high levels macrophages linked obesity. But oscillations [NADPH]/[NADP+] feeding cycles play important role maintaining metabolic plasticity drive Studies measuring malate/pyruvate as proxy [NADPH]/[NADP+], well studies using fluorescent biosensors expressed animal models monitor changes needed during ad libitum diets determine associated with

Language: Английский

Citations

3
Nicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice DOI Creative Commons
Caifang Ren,

Zhang Shuang,

Jianyu Ma

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1028 - 1028

Published: Dec. 8, 2024

Polycystic ovary syndrome (PCOS) involves complex genetic, metabolic, endocrine, and environmental factors. This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation. Letrozole-induced aromatase inhibition elevated androgen reduced bile acid levels, linking liver dysfunction gut imbalance to PCOS. Letrozole-treated mice exhibited disrupted estrous cycles, ovarian congestion, testosterone. NMN intervention alleviated hyperandrogenism, abnormalities, decline but did not fully restore cycle or improve lipid profiles. Metabolomic analysis showed that partially reversed metabolism disturbances. These findings highlight NMN’s protective role reducing hyperandrogenism cyst formation. However, effective treatment should target metabolism, just symptoms, mitigate systemic effects. Bile dysregulation may play key progression warrants further investigation.

Language: Английский

Citations

0