International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(12), P. 6262 - 6262
Published: June 10, 2021
Colorectal
carcinoma
(CRC)
is
one
of
the
most
frequently
diagnosed
carcinomas
and
leading
causes
cancer-related
death
worldwide.
Metabolic
reprogramming,
a
hallmark
cancer,
closely
related
to
initiation
progression
carcinomas,
including
CRC.
Accumulating
evidence
shows
that
activation
oncogenic
pathways
loss
tumor
suppressor
genes
regulate
metabolic
reprogramming
mainly
involved
in
glycolysis,
glutaminolysis,
one-carbon
metabolism
lipid
metabolism.
The
abnormal
program
provides
cells
with
abundant
energy,
nutrients
redox
requirements
support
their
malignant
growth
metastasis,
which
accompanied
by
impaired
flexibility
microenvironment
(TME)
dysbiosis
gut
microbiota.
crosstalk
between
cells,
components
TME
intestinal
microbiota
further
facilitates
CRC
cell
proliferation,
invasion
metastasis
leads
therapy
resistance.
Hence,
target
dysregulated
metabolism,
microbiota,
novel
preventive
therapeutic
applications
are
required.
In
this
review,
dysregulation
programs,
molecular
pathways,
addressed.
Possible
strategies,
inhibition
immune
CRC,
as
well
modulation
aberrant
discussed.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 115586 - 115586
Published: Dec. 1, 2023
Metabolic
diseases,
featured
with
dysregulated
energy
homeostasis,
have
become
major
global
health
challenges.
Patients
metabolic
diseases
high
probability
to
manifest
multiple
complications
in
lipid
metabolism,
e.g.
obesity,
insulin
resistance
and
fatty
liver.
Therefore,
targeting
the
hub
genes
metabolism
may
systemically
ameliorate
along
complications.
Stearoyl-CoA
desaturase
1(SCD1)
is
a
key
enzyme
that
desaturates
saturated
acids
(SFAs)
derived
from
de
novo
lipogenesis
or
diet
generate
monounsaturated
(MUFAs).
SCD1
maintains
tissue
homeostasis
by
responding
to,
integrating
layers
of
endogenous
stimuli,
which
mediated
synthesized
MUFAs.
It
critically
regulates
myriad
physiological
processes,
including
development,
autophagy,
tumorigenesis
inflammation.
Aberrant
transcriptional
epigenetic
activation
AMPK/ACC,
SIRT1/PGC1α,
NcDase/Wnt,
etc,
causes
aberrant
accumulation,
thereby
promoting
progression
non-alcoholic
liver,
diabetes
cancer.
This
review
assesses
integrative
mechanisms
(patho)physiological
functions
inflammation
autophagy.
For
translational
perspective,
potent
inhibitors
been
developed
treat
various
types
We
thus
discuss
multidisciplinary
advances
greatly
accelerate
development
new
inhibitors.
In
conclusion,
besides
cancer
treatment,
serve
as
promising
target
combat
simultaneously.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 14, 2024
Cancer
has
become
a
serious
health
burden
that
results
in
high
incidence
and
mortality
rates
every
year,
mainly
due
to
various
molecular
alterations
inside
the
cell.
Liver
X
receptors
(LXRs)
dysregulation
is
one
among
them
plays
vital
role
cholesterol
metabolism,
lipid
metabolism
inflammation
also
crucial
diseases
such
as
obesity,
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD),
cardiovascular
diseases,
Type
2
diabetes,
osteoporosis,
cancer.
Studies
report
activation
of
LXRs
inhibits
cancer
growth
by
inhibiting
cellular
proliferation,
inducing
apoptosis
autophagy,
regulating
signalling
pathways
Wnt,
PI3K/AKT,
modulating
expression
levels
cell-cycle
regulators,
promoting
antitumor
immunity
tumor
microenvironment.
In
this
review,
we
have
discussed
role,
structure,
functions
summarized
their
ligands
along
with
mechanism
action.
addition,
cancers,
microenvironment
(TME)
importance
precision
medicine
LXR-targeted
therapies
been
emphasize
potent
targets
for
development
novel
therapeutics.
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: Sept. 12, 2022
Aberrant
lipid
metabolism
is
nonnegligible
for
tumor
cells
to
adapt
the
microenvironment
(TME).
It
plays
a
significant
role
in
amount
and
function
of
immune
cells,
including
tumor-associated
macrophages,
T
dendritic
marrow-derived
suppressor
cells.
well-known
that
response
TME
suppressed
closely
involved
this
process.
Immunotherapy,
containing
anti-PD1/PDL1
therapy
adoptive
cell
therapy,
crucial
clinical
cancer
therapeutic
strategy
nowadays,
but
they
display
low-sensibility
certain
cancers.
In
review,
we
mainly
discussed
importance
formation
immunosuppressive
TME,
explored
effectiveness
sensitivity
immunotherapy
treatment
by
regulating
metabolism.
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
19(10), P. 3115 - 3127
Published: Jan. 1, 2023
Lipid
metabolism
plays
an
important
role
in
the
occurrence
and
development
of
cancer,
particular,
digestive
system
tumors
such
as
colon
cancer.
Here,
we
investigated
fatty
acid-binding
protein
5
(FABP5)
colorectal
cancer
(CRC).
We
observed
marked
down-regulation
FABP5
CRC.
Data
from
functional
assays
revealed
inhibitory
effects
on
cell
proliferation,
colony
formation,
migration,
invasion
well
tumor
growth
vivo.
In
terms
mechanistic
insights,
interacted
with
acid
synthase
(FASN)
activated
ubiquitin
proteasome
pathway,
leading
to
a
decrease
FASN
expression
lipid
accumulation,
moreover,
suppressing
mTOR
signaling
facilitating
autophagy.
Orlistat,
inhibitor,
exerted
anti-cancer
both
vivo
vitro.
Furthermore,
upstream
RNA
demethylase
ALKBH5
positively
regulated
via
m6A-independent
mechanism.
Overall,
our
collective
findings
offer
valuable
insights
into
critical
ALKBH5/FABP5/FASN/mTOR
axis
progression
uncover
potential
mechanism
linking
CRC,
providing
novel
therapeutic
targets
for
future
interventions.
Cancer Immunology Research,
Journal Year:
2024,
Volume and Issue:
12(12), P. 1691 - 1702
Published: Aug. 26, 2024
Abstract
Ferroptosis
is
an
iron-dependent
form
of
cell
death
that
influences
cancer
immunity.
Therapeutic
modulation
ferroptosis
considered
a
potential
strategy
to
enhance
the
efficacy
other
therapies,
including
immunotherapies
such
as
chimeric
antigen
receptor
(CAR)
T-cell
therapy.
In
this
study,
we
demonstrated
IFNκ
influenced
induction
ferroptosis.
could
sensitivity
tumor
cells
induced
by
small
molecule
compound
erastin
and
polyunsaturated
fatty
acid
arachidonic
acid.
Mechanistically,
in
combination
with
immunogenic
via
IFNAR/STAT1/ACSL4
axis.
Moreover,
CAR
T
engineered
express
showed
increased
antitumor
efficiency
against
H460
(antigen
positive)
H322
(antigen-negative)
both
vitro
vivo.
We
conclude
cytokine
be
harnessed
function
inducing
Frontiers in Genetics,
Journal Year:
2022,
Volume and Issue:
13
Published: March 22, 2022
There
are
a
plethora
of
cancer
causes
and
the
road
to
fully
understanding
carcinogenesis
process
remains
dream
that
keeps
changing.
However,
list
role
players
implicated
in
carcinogens
is
getting
lengthier.
Cholesterol
known
as
bad
sterol
heavily
linked
with
cardiovascular
diseases;
however,
it
also
comprehensively
associated
carcinogenesis.
an
extensive
strategies
have
been
used
lower
cholesterol;
nevertheless,
need
find
better
effective
vastly
important.
The
played
by
cholesterol
induction
has
attracted
huge
interest
recent
years.
Phytochemicals
can
be
dubbed
magic
tramp
cards
humans
could
exploit
for
lowering
cancer-causing
cholesterol.
Additionally,
mechanisms
regulated
phytochemicals
targeted
anticancer
drug
development.
One
key
development
suppression,
Tumour
Protein
53
(TP53),
crucial
regulating
biogenesis
several
phytochemicals.
This
minireview
covers
p53
mevalonate
pathway
how
bioactive
target
promote
p53-dependent
activities.
Metabolites,
Journal Year:
2022,
Volume and Issue:
12(3), P. 213 - 213
Published: Feb. 26, 2022
Colorectal
cancer
(CRC)
to
date
still
ranks
as
one
of
the
deadliest
entities
globally,
and
despite
recent
advances,
incidence
in
young
adolescents
is
dramatically
increasing.
Lipid
metabolism
has
recently
received
increased
attention
a
crucial
element
for
multiple
aspects
carcinogenesis
our
knowledge
underlying
mechanisms
steadily
growing.
However,
mechanism
how
fatty
acid
contributes
CRC
not
understood
detail.
In
this
review,
we
aim
summarize
vastly
growing
comprehension
accompanied
complexity
cellular
by
describing
inputs
outputs
intracellular
free
pools
these
contribute
initiation,
disease
progression
metastasis.
We
highlight
different
lipid
pathways
can
aggressiveness
tumors
affect
prognosis
patients.
Furthermore,
focus
on
role
cell
communication
interplay
within
tumor
microenvironment
(TME)
beyond.
Understanding
interactions
depth
might
lead
discovery
novel
markers
new
therapeutic
interventions
CRC.
Finally,
discuss
targetable
gatekeeper
colorectal
cancer.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(14), P. 11786 - 11786
Published: July 22, 2023
The
involvement
of
cardiovascular
disease
in
cancer
onset
and
development
represents
a
contemporary
interest
basic
science.
It
has
been
recognized,
from
the
most
recent
research,
that
metabolic
syndrome-related
conditions,
ranging
atherosclerosis
to
diabetes,
elicit
many
pathways
regulating
lipid
metabolism
signaling
are
also
linked
same
framework
multiple
potential
mechanisms
for
inducing
cancer.
Otherwise,
dyslipidemia
endothelial
cell
dysfunction
may
present
common
or
even
interdependent
changes,
similar
oncogenic
molecules
elevated
forms
However,
whether
atherosclerotic
provides
signals
promote
pre-clinical
proliferation
malignant
cells
is
an
issue
requires
further
understanding,
though
more
questions
presented
with
every
answer.
Here,
we
highlight
molecular
point
causal
link
between
glucose
homeostasis
knowledge
these
breakthrough
pave
way
application
new
therapeutic
targets
implementing
interventions
clinical
practice.
