International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137328 - 137328
Published: Nov. 6, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7810 - 7810
Published: July 17, 2024
Nowadays, as a result of the frequent occurrence accidental injuries and traumas such bone damage, number people causing or fractures is increasing around world. The design fabrication ideal tissue engineering (BTE) materials have become research hotspot in scientific community, thus provide novel path for treatment diseases. Among used to construct scaffolds BTE, including metals, bioceramics, bioglasses, biomacromolecules, synthetic organic polymers, etc., natural biopolymers more advantages against them because they can interact with cells well, polymers be widely studied applied field BTE. In particular, alginate has excellent biocompatibility, good biodegradability, non-immunogenicity, non-toxicity, wide sources, low price, easy gelation, enabling itself biomaterial. However, pure hydrogel BTE scaffold material still many shortcomings, insufficient mechanical properties, disintegration physiological environments, lack cell-specific recognition sites, which severely limits its clinical application order overcome defects single hydrogels, researchers prepared composite hydrogels by adding one matrix certain proportion improve their bioapplicability. For this reason, review will introduce detail methods constructing alginate/polymer alginate/bioprotein polypeptide alginate/bioceramic alginate/nanoclay well biological trends materials, look forward future direction. These exhibit both unexceptionable biochemical high value repair regeneration, providing theoretical basis development sustainable alginate-based functional biomedical materials.
Language: Английский
Citations
14
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36258 - e36258
Published: Aug. 1, 2024
Natural bone tissue has the certain function of self-regeneration and repair, but it is difficult to repair large damage. Recently, although autologous grafting "gold standard" for improving high cost, few donor sources. Besides, allogeneic causes greater immune reactions, which hardly meet clinical needs. The engineering (BTE) been developed promote repair. Gelatin, due its biocompatibility, receives a great deal attention in BTE research field. However, disadvantages natural gelatin are poor mechanical properties single structural property. With development BTE, often used combination with range natural, synthetic polymers, inorganic materials achieve synergistic effects complex physiological process review delves into fundamental structure unique gelatin, as well excellent necessary scaffold materials. Then this explores application modified three-dimensional (3D) scaffolds various structures including 3D fiber scaffolds, hydrogels, nanoparticles. In addition, focuses on efficacy composite consisting or polymeric materials, bioactive ceramics metallic/non-metallic defects. these gelatin-based provides new ideas design good biosafety.
Language: Английский
Citations
13
Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140855 - 140855
Published: Feb. 1, 2025
Language: Английский
Citations
1
Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 252 - 252
Published: Jan. 20, 2025
The applications of polymeric materials are being constantly reviewed and improved. In the present world, word hybrid, general idea combining two or more inherently different approaches, designs, is gaining significant attention. area sustainable with a low environmental impact also rapidly evolving many new discoveries, including use natural origin countless combinations thereof. This review tries to summarize current state knowledge about hybrid their special attention that can be considered “environmentally friendly”. As application field quite broad, was limited following topics: packaging, medical applications, sensors, water purification, electromagnetic shielding. Furthermore, this points out prospects challenges for mentioned in terms creating novel solutions nano micro-materials mostly renewable origin.
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(3), P. 196 - 196
Published: Jan. 26, 2025
Current investigations into the fabrication of innovative biomaterials that stimulate cartilage development result from increasing interest due to emerging bone defects. In particular, investigation for musculoskeletal therapies extensively depends on various hydroxyapatite (HA)/sodium alginate (SA) composites. Cuttlefish (CFB)-derived composite scaffolds hard tissue regeneration have been effectively illustrated in this using a hydrothermal technique. this, HA was prepared CFB source without altering its biological properties. The as-developed nanocomposites were investigated through XRD, FTIR, SEM, and EDX analyses confirm their structural, functional, morphological orientation. higher interfacial density HA/SA nanocomposites, more hardness scaffold increased with applied load. Furthermore, nanocomposite revealed remarkable antibacterial activity against bacterial strains such as E. coli S. aureus inhibition zones measured 18 mm 20 mm, respectively. results demonstrated minor decrease cell viability compared untreated culture, an observed percentage at 97.2% nanocomposites. Hence, proposed would be excellent alternative engineering applications.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141160 - 141160
Published: Feb. 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160946 - 160946
Published: Feb. 1, 2025
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 178 - 178
Published: March 1, 2025
Biopolymer hydrogel-based scaffold materials have received a lot of interest in tissue engineering and regenerative medicine because their unique characteristics, which include biocompatibility, biodegradability, the ability to replicate natural extracellular matrix (ECM). These hydrogels are three-dimensional biopolymer networks that highly hydrated provide supportive, wet environment conducive cell growth, migration, differentiation. They especially useful applications involving wound healing, cartilage, bone, soft regeneration. Natural biopolymers such as collagen, chitosan, hyaluronic acid, alginate frequently employed foundation for hydrogel fabrication, providing benefits low toxicity improved adherence. Despite potential, scaffolds various difficulties prevent broad clinical implementation. Key challenge balancing mechanical strength flexibility meet needs tissues, managing degradation rates line up with regeneration, assuring large-scale manufacturing while retaining uniformity quality. Furthermore, fostering appropriate vascularization infiltration larger tissues remains significant optimal integration function. Future developments likely concentrate on addressing these obstacles. Strategies creation hybrid combine synthetic materials, smart stimulus-responsive features, 3D bioprinting technologies accurate production show potential. integrating bioactive compounds growth factors into matrices promote regeneration is critical enhancing therapeutic results.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106789 - 106789
Published: March 1, 2025
Language: Английский
Citations
0