Multifunctional metal–organic frameworks for wound healing and skin regeneration

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112252 - 112252

Published: Aug. 18, 2023

Various wounds caused by burns, trauma, surgery, and genetic irregularities, including acute chronic wounds, pose a huge burden on global healthcare. Many therapeutic strategies, such as nanomedicine regenerative medicine, have been applied to wound repair skin regeneration. As promising exciting nanomaterial, metal-organic frameworks (MOFs) encompass many desirable properties, crystalline porous structure, tunable size, good mechanical stability, large specific surface area, exceptional chemical stability. Most importantly, the performance of MOFs can be modulated changing synthesis steps conditions. release metal ions modulate cellular behaviors kill various microorganisms, which meets this dual agent strategy for healing Additionally, act carriers delivering bioactive agents in desired manner. Recently, an increasing number researchers conducted studies applying Based this, we perform study report current status further perspective MOFs-based strategy. Furthermore, molecular process fabrication were also discussed.

Language: Английский

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A review of biomacromolecule-based 3D bioprinting strategies for structure-function integrated repair of skin tissues

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131623 - 131623

Published: April 19, 2024

Language: Английский

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Biomaterial-Based Regenerative Strategies for Volumetric Muscle Loss: Challenges and Solutions

Advances in Wound Care, Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Volumetric muscle loss (VML) is caused by the of significant amounts skeletal tissue. VML cannot be repaired intrinsic regenerative processes, resulting in permanent function and disability. Current rehabilitative-focused treatment strategies lack efficacy do not restore function, indicating need for development effective strategies.

Language: Английский

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Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4145 - 4174

Published: June 1, 2024

3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks bioprinters to construct tissues or organs, thereby eliminating stipulation for artificial organs. For of soft tissues, such kidneys, hearts, other human body parts, formulations bioink enhanced bioinspired rheological mechanical properties were essential. Nanomaterials-based hybrid have potential overcome above-mentioned problem require much attention among researchers. Natural synthetic nanomaterials carbon nanotubes, graphene oxides, titanium nanosilicates, nanoclay, nanocellulose, etc. their blended been used various benefitted bioprintability, biocompatibility, biodegradability. A limited number articles published, requirement pushed us write this review. We reviewed, explored, discussed nanocomposite-based technology, properties, natural, synthetic, nanomaterial-based bioinks, including applications challenges, limitations, ethical considerations, solution future perspective, technological advancement efficient cost-effective methods regeneration healthcare.

Language: Английский

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Recent advances in biofabrication strategies based on bioprinting for vascularized tissue repair and regeneration

Materials & Design, Journal Year: 2023, Volume and Issue: 229, P. 111885 - 111885

Published: March 31, 2023

Vascularization plays a crucial role in transporting and exchanging nutrients oxygen between implanted grafts with the host tissue. In biofabrication of grafts, remodeling vascular networks can accelerate vascularized tissue repair regeneration. Given heterogeneity tissues, traditional scaffold manufacturing techniques cannot effectively achieve various scales vitro vivo biomimetic. recent years, 3D bioprinting technologies have been widely used fabricating for regeneration due to their shape customizability, simple procedure, reproducibility, precise multi-dimensional control. With rapid development technologies, bioprinting-based strategies gradually applied construction tissues. Based on this background, our study aimed review advances, challenges, future perspectives based The techniques, bioinks, seed cells, growth factors were also enrolled review. addition, history, vessel formation mechanism, histology discussed.

Language: Английский

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4D Bioprinting for Personalized Medicine, Innovations in Implant Fabrication and Regenerative Therapies

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: March 30, 2025

Language: Английский

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Modular Living Muscle‐Based Biomimetic Actuators for Biosyncretic Robots

Published: April 10, 2025

ABSTRACT Biosyncretic robots that integrate living materials present unique advantages for advancing robotic research. Compared with traditional robots, biosyncretic offer potential benefits such as higher energy efficiency and enhanced biocompatibility. Among various bioactuators, skeletal muscle tissue (SMT) is particularly favored its scalability, to generate high driving forces, controllable on/off actuation. However, current SMT actuators often face challenges, including a limited force suboptimal practical designs, which may impede the development of robots. To address these limitations, this work proposes method fabricating modular actuators. By leveraging biomimetic design structural optimization, contractile performance significantly improved. The achieved maximum 2.92 ± 0.07 mN, demonstrated approximately 28% strain under unloaded conditions, notably exhibited responsive single‐twitch contractions electrical stimulation frequencies up 10 Hz. This response outperforms most existing robot studies. In addition, highly adaptable can be easily assembled construct human‐like actuators, convergent, parallel, bipennate muscles. integrating rigid‐flexible coupled nonliving structures, SMT‐driven caterpillar, dolphin, manta ray have been successfully developed. research presents an innovative approach constructing large, high‐performance, multifunctional contributing advancements in both (or biohybrid robots) engineering.

Language: Английский

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Fabrication of cell cultured meat by hydrogel with topographic microstructures

Food Bioscience, Journal Year: 2023, Volume and Issue: 55, P. 102910 - 102910

Published: July 18, 2023

Language: Английский

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Bioengineered cell-constructs using decellularized fish skin-based composite bioink for regenerating muscle tissue

Applied Physics Reviews, Journal Year: 2024, Volume and Issue: 11(2)

Published: April 1, 2024

A biocomposite for enhancing muscle tissue regeneration was introduced using decellularized fish skins. Decellularized tilapia and cod skin were explored as constituents of the composite compared with conventionally used extracellular matrix (dECM) derived from porcine tissue. As a cell-laden bioink 3D bioprinting, choice dECM, which possesses remarkable printability, allows precise three-dimensional (3D) structure fabrication. Meanwhile, dECM selected dispersed phase biological activities because its omega-3 unsaturated fatty acid, is known to promote angiogenesis crucial nutrient supply during lower inflammation. Through meticulous compositional optimization dECMs, efficient printability high myogenic activity attained. In vitro evaluations adipose stem cells clearly demonstrated support myogenesis, determined by various cellular activities, including genes, those porcine-based bioink. The regenerative potential composites validated an in vivo mouse model volumetric loss. Based on these results, this study provides valuable insights into use biomaterials demonstrates their distinct advantages engineering, terms both bioactivity induction.

Language: Английский

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Process control of electrospinning artificial fenestrated capillary vessels

Materials & Design, Journal Year: 2023, Volume and Issue: 227, P. 111708 - 111708

Published: Feb. 11, 2023

Rapid fabrication of capillary vessels is important for tissue engineering because local perfusion and oxygen exchange within the depend on network capillaries which have diameters ranging from 5 to 10 µm. Fenestrated are microvessels that surface pores 80 100 nm in diameter. These essential many organs, such as small intestines, endocrine glands, kidneys. In this paper, we presented a wet coaxial electrospinning technique rapid porous microtubes artificial fenestrated using polycaprolactone polyethylene oxide. We characterized effects process parameters morphological features these by regression modeling. Our study shows flow rate ratio core/sheath solutions viscosity sheath solution play significant role outside diameter, wall thickness, hollow area microtubes. addition, formation dominated humidity during electrospinning. At same level, size positively correlated with diameter Overall, established process-property relationship capillaries.

Language: Английский

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