Annual Review of Immunology,
Journal Year:
2022,
Volume and Issue:
40(1), P. 143 - 167
Published: Jan. 6, 2022
The
gut
microbiome
influences
many
host
physiologies,
spanning
gastrointestinal
function,
metabolism,
immune
homeostasis,
neuroactivity,
and
behavior.
Many
microbial
effects
on
the
are
orchestrated
by
bidirectional
interactions
between
system.
Imbalances
in
this
dialogue
can
lead
to
dysfunction
immune-mediated
conditions
distal
organs
including
brain.
Dysbiosis
of
dysregulated
neuroimmune
responses
common
comorbidities
neurodevelopmental,
neuropsychiatric,
neurological
disorders,
highlighting
importance
microbiome-neuroimmune
axis
as
a
regulator
central
nervous
system
homeostasis.
In
review,
we
discuss
recent
evidence
supporting
role
for
regulating
landscape
health
disease.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2022,
Volume and Issue:
64(9), P. 2461 - 2489
Published: Sept. 26, 2022
Fatty
acids
are
good
energy
sources
(9
kcal
per
gram)
that
aerobic
tissues
can
use
except
for
the
brain
(glucose
is
an
alternative
source).
Apart
from
source,
fatty
necessary
cell
signaling,
learning-related
memory,
modulating
gene
expression,
and
functioning
as
cytokine
precursors.
Short-chain
(SCFAs)
saturated
arranged
a
straight
chain
consisting
minimum
of
6
carbon
atoms.
SCFAs
possess
various
beneficial
effects
like
improving
metabolic
function,
inhibiting
insulin
resistance,
ameliorating
immune
dysfunction.
In
this
review,
we
discussed
biogenesis,
absorption,
transport
SCFA.
act
signaling
molecules
by
stimulating
G
protein-coupled
receptors
(GPCRs)
suppressing
histone
deacetylases
(HDACs).
The
role
SCFA
on
glucose
metabolism,
acid
its
effect
system
also
reviewed
with
updated
details.
anticancer,
anti-diabetic,
hepatoprotective
effects.
Additionally,
association
protective
against
brain-related
diseases,
kidney
cardiovascular
damage,
inflammatory
bowel
diseases
were
reviewed.
Nanotherapy
branch
nanotechnology
employs
nanoparticles
at
nanoscale
level
to
treat
ailments
enhanced
drug
stability,
solubility,
minimal
side
functions
carriers,
discussed.
Still,
much
research
was
not
focused
area.
in
host
expression
through
inhibition
HDAC
inhibition.
However,
study
has
be
molecular
mechanism
still
need
investigated.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 25, 2021
Autism
spectrum
disorders
(ASD)
are
serious,
highly
variable
neurodevelopmental
disorders,
commonly
characterized
by
the
manifestation
of
specific
behavioral
abnormalities,
such
as
stereotypic
behaviors
and
deficits
in
social
skills,
including
communication.
Although
neurobiological
basis
for
ASD
has
attracted
attention
recent
decades,
role
microglial
cells,
which
main
resident
myeloid
cell
population
brain,
is
still
controversial
underexplored.
Microglia
play
several
fundamental
roles
orchestrating
brain
development
homeostasis.
As
such,
alterations
intrinsic
functions
these
cells
could
be
one
driving
forces
responsible
various
ASD.
sensitive
to
environmental
cues.
Amongst
factors
known
influence
their
functions,
gut
microbiota
emerged
a
central
player,
controlling
both
maturation
activation.
Strikingly,
there
now
compelling
data
suggesting
that
intestinal
can
causative
behavioural
changes
associated
with
Not
only
dysbiosis
reported
patients,
but
therapies
targeting
microbiome
markedly
alleviate
symptoms.
Here
we
explore
emerging
mechanisms
altered
contribute
major
etiological
We
then
demonstrate
how
pre-
postnatal
stimuli
modulate
phenotype
function,
underpinning
notion
reciprocal
interactions
between
microglia
microbes
crucial
aetiology.
AJP Gastrointestinal and Liver Physiology,
Journal Year:
2021,
Volume and Issue:
320(4), P. G601 - G608
Published: Jan. 6, 2021
Butyrate
is
a
short-chain
fatty
acid
produced
by
colonic
gut
bacteria
as
result
of
fermentation
dietary
fibers.
In
the
colon,
butyrate
major
energy
substrate
and
contributes
to
nutritional
support
proliferation
healthy
mucosa.
It
also
promotes
intestinal
barrier
function
enhancing
mucus
production
tight
junctions.
addition
its
pro-proliferative
effect
in
colonocytes,
inhibits
cancer
cells.
The
antineoplastic
associated
with
inhibitory
on
histone
deacetylase
(HDAC)
enzymes,
which
promote
carcinogenesis.
Due
metabolic
shift
cells
toward
glycolysis,
unused
accumulates
procarcinogenic
HDACs.
addition,
recent
studies
suggest
that
may
improve
healing
tissue
after
surgery
animal
models,
specifically
at
site
reconnection
ends,
anastomosis,
surgical
resection.
Here,
we
review
current
evidence
impact
epithelial
integrity
colorectal
present
knowledge
data
potential
applications
practice.
Annual Review of Immunology,
Journal Year:
2022,
Volume and Issue:
40(1), P. 143 - 167
Published: Jan. 6, 2022
The
gut
microbiome
influences
many
host
physiologies,
spanning
gastrointestinal
function,
metabolism,
immune
homeostasis,
neuroactivity,
and
behavior.
Many
microbial
effects
on
the
are
orchestrated
by
bidirectional
interactions
between
system.
Imbalances
in
this
dialogue
can
lead
to
dysfunction
immune-mediated
conditions
distal
organs
including
brain.
Dysbiosis
of
dysregulated
neuroimmune
responses
common
comorbidities
neurodevelopmental,
neuropsychiatric,
neurological
disorders,
highlighting
importance
microbiome-neuroimmune
axis
as
a
regulator
central
nervous
system
homeostasis.
In
review,
we
discuss
recent
evidence
supporting
role
for
regulating
landscape
health
disease.
