Journal of Functional Foods,
Journal Year:
2023,
Volume and Issue:
107, P. 105669 - 105669
Published: July 5, 2023
Tea
polyphenols
(TPs)
have
shown
several
memory-enhancing
activities.
The
gut
microbiota
is
essential
in
developing
neurodegenerative
diseases
as
a
critical
regulator
of
brain-gut
axis
function.
the
modulates
neuronal
activity
and
activates
microglia
through
immune
system,
amino
acid
metabolism,
visceral
nerves,
thereby
exerting
regulatory
effect
on
brain
TPs
advantage
multi-targeting,
high
safety
profiles
compared
to
drugs
great
potential
preventing
treating
diseases.
In
addition,
they
can
effectively
modulate
composition
microbiota.
Studies
been
undertaken
into
mechanisms
related
preventative
mediated
by
This
review
discussed
preventive
mechanism
modulating
host
microbiota,
may
be
regarded
neuroprotective
substances
with
efficiency.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(13), P. 2661 - 2661
Published: June 27, 2022
The
involvement
of
the
gut
microbiota
and
metabolites
colon-residing
bacteria
in
brain
disease
pathogenesis
has
been
covered
a
growing
number
studies,
but
comparative
literature
is
scarce.
To
fill
this
gap,
we
explored
contribution
microbiota-gut-brain
axis
to
pathophysiology
seven
brain-related
diseases
(attention
deficit
hyperactivity
disorder,
autism
spectrum
schizophrenia,
Alzheimer's
disease,
Parkinson's
major
depressive
bipolar
disorder).
In
article,
discussed
changes
bacterial
abundance
metabolic
implications
these
on
development
progression.
Our
central
findings
indicate
that,
mechanistically,
all
are
associated
with
leaky
gut,
neuroinflammation,
over-activated
microglial
cells,
which
gut-residing
their
important
contributors.
Patients
show
pro-inflammatory
shift
colon
microbiota,
harbouring
more
Gram-negative
containing
immune-triggering
lipopolysaccharides
(LPS)
cell
walls.
addition,
properties
(
Life,
Journal Year:
2024,
Volume and Issue:
14(5), P. 559 - 559
Published: April 26, 2024
The
gastrointestinal
tract
is
home
to
trillions
of
diverse
microorganisms
collectively
known
as
the
gut
microbiota,
which
play
a
pivotal
role
in
breaking
down
undigested
foods,
such
dietary
fibers.
Through
fermentation
these
food
components,
short-chain
fatty
acids
(SCFAs)
acetate,
propionate,
and
butyrate
are
produced,
offering
numerous
health
benefits
host.
production
absorption
SCFAs
occur
through
various
mechanisms
within
human
intestine,
contingent
upon
types
fibers
reaching
specific
engaged
fermentation.
Medical
literature
extensively
documents
supplementation
SCFAs,
particularly
butyrate,
treatment
gastrointestinal,
metabolic,
cardiovascular,
gut-brain-related
disorders.
This
review
seeks
provide
an
overview
dynamics
involved
gut.
Additionally,
it
will
focus
on
roles
promoting
metabolic
health,
well
their
current
therapeutic
implications.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 22, 2025
The
gut
microbiome
has
emerged
as
a
pivotal
area
of
research
due
to
its
significant
influence
on
the
immune
system
and
cognitive
functions.
Cognitive
disorders,
including
dementia
Parkinson’s
disease,
represent
substantial
global
health
challenges.
This
review
explores
relationship
between
microbiota,
modulation,
decline,
with
particular
focus
gut-brain
axis.
Research
indicates
that
bacteria
produce
metabolites,
short-chain
fatty
acids
(SCFAs),
which
affect
mucosal
immunity,
antigen
presentation,
responses,
thereby
influencing
A
noteworthy
correlation
been
identified
imbalances
in
impairments,
suggesting
novel
pathways
for
treatment
disorders.
Additionally,
factors
such
diet,
environment,
pharmaceuticals
play
role
shaping
composition
microbiome,
subsequently
impacting
both
health.
article
aims
clarify
complex
interactions
among
regulation,
evaluating
their
potential
therapeutic
targets.
goal
is
promote
microbiome-based
treatments
lay
groundwork
future
this
field.
Foods,
Journal Year:
2025,
Volume and Issue:
14(1), P. 101 - 101
Published: Jan. 2, 2025
Alzheimer’s
disease
(AD)
is
marked
by
impaired
cognitive
functions,
particularly
in
learning
and
memory,
owing
to
complex
diverse
mechanisms.
Methionine
restriction
(MR)
has
been
found
exert
a
mitigating
effect
on
brain
oxidative
stress
improve
AD.
However,
the
bidirectional
crosstalk
between
gut
through
which
MR
enhances
memory
AD,
as
well
effects
of
fecal
microbiota
transplantation
(FMT)
from
mice
AD
mice,
remains
underexplored.
In
this
study,
APP/PS1
double
transgenic
were
used
an
FMT
experiment
was
conducted.
16S
rRNA
gene
sequencing,
targeted
metabolomics,
microbial
metabolite
short-chain
fatty
acids
(SCFAs)
feces
samples
analyzed.
The
results
showed
that
reversed
reduction
SCFAs
induced
further
activated
free
acid
receptors,
FFAR2
FFAR3,
transport
protein
MCT1,
thereby
signaling
mitigate
inflammation
enhance
capabilities.
Furthermore,
methionine-restricted
diet
mouse
donors
receiving
ameliorated
ability
SCFAs.
This
study
offers
novel
non-pharmaceutical
intervention
strategies
for
prevention.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 347 - 347
Published: Jan. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 22, 2022
Neurological
disorders
(NDs)
are
one
of
the
leading
causes
global
death.
A
sustained
neuroinflammatory
response
has
been
reported
to
be
associated
with
pathogenesis
multiple
NDs,
including
Parkinson’s
disease
(PD),
sclerosis
(MS),
Alzheimer’s
(AD),
amyotrophic
lateral
(ALS),
and
major
depressive
disorder
(MDD).
Accumulating
evidence
shows
that
recruitment
abundant
lymphocytes
in
central
nervous
system
may
contribute
promoting
development
progress
inflammation
neurological
disorders.
As
subset
T
lymphocytes,
CD4
+
cells
have
a
critical
impact
on
helper
(Th)
17
is
most
studied
Th
subpopulations
produces
cytokines
(e.g.,
IL-17A,
IL-23,
IL-21,
IL-6,
IFN-γ),
abnormal
excessive
activation
microglia
other
immune
cell
types.
All
these
factors
involved
several
However,
possible
mechanisms
Th17
their
immunopathology
abovementioned
not
clarified
completely.
This
review
will
summarize
by
which
encephalitogenic
inflammatory
related
strongly
chronic
neuroinflammation,
thus
perpetuating
neurodegenerative
processes
NDs.
Finally,
potential
therapeutic
prospects
NDs
also
discussed.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(14), P. 4130 - 4130
Published: July 15, 2024
Neurodegenerative
diseases,
such
as
Alzheimer’s
disease
(AD)
and
Parkinson’s
(PD),
are
severe
age-related
disorders
with
complex
multifactorial
causes.
Recent
research
suggests
a
critical
link
between
neurodegeneration
the
gut
microbiome,
via
gut–brain
communication
pathway.
This
review
examines
role
of
trimethylamine
N-oxide
(TMAO),
microbiota-derived
metabolite,
in
development
AD
PD,
investigates
its
interaction
microRNAs
(miRNAs)
along
this
bidirectional
TMAO,
which
is
produced
from
dietary
metabolites
like
choline
carnitine,
has
been
linked
to
increased
neuroinflammation,
protein
misfolding,
cognitive
decline.
In
AD,
elevated
TMAO
levels
associated
amyloid-beta
tau
pathologies,
blood–brain
barrier
disruption,
neuronal
death.
can
cross
promote
aggregation
amyloid
proteins.
Similarly,
affects
alpha-synuclein
conformation
aggregation,
hallmark
PD.
also
activates
pro-inflammatory
pathways
NF-kB
signaling,
exacerbating
neuroinflammation
further.
Moreover,
modulates
expression
various
miRNAs
that
involved
neurodegenerative
processes.
Thus,
microbiome–miRNA–brain
axis
represents
newly
discovered
mechanistic
dysbiosis
neurodegeneration.
MiRNAs
regulate
key
oxidative
stress,
death,
contributing
progression.
As
direct
consequence,
specific
miRNA
signatures
may
serve
potential
biomarkers
for
early
detection
monitoring
PD
aims
elucidate
interrelationships
microbiota,
trimethylamine-N-oxide
(miRNAs),
central
nervous
system,
implications
these
connections
diseases.
context,
an
overview
current
neuroradiology
techniques
available
studying
animal
models
used
investigate
intricate
pathologies
will
be
provided.
summary,
bulk
evidence
supports
concept
modulating
pathway
through
changes,
manipulation
and/or
miRNA-based
therapies
offer
novel
approaches
implementing
treatment
debilitating
neurological
disorders.
Cell Reports,
Journal Year:
2024,
Volume and Issue:
43(3), P. 113865 - 113865
Published: Feb. 26, 2024
Microbial
metabolites
that
can
modulate
neurodegeneration
are
promising
therapeutic
targets.
Here,
we
found
the
short-chain
fatty
acid
propionate
protects
against
α-synuclein-induced
neuronal
death
and
locomotion
defects
in
a
Caenorhabditis
elegans
model
of
Parkinson's
disease
(PD)
through
bidirectional
regulation
between
intestine
neurons.
Both
depletion
dietary
vitamin
B
