The Gut Microbiome-Neuroglia Axis: Implications for Brain Health, Inflammation, and Disease DOI Creative Commons
Josué Camberos-Barraza, Alma Marlene Guadrón‐Llanos, Alberto K. De la Herrán-Arita

et al.

Neuroglia, Journal Year: 2024, Volume and Issue: 5(3), P. 254 - 273

Published: Aug. 1, 2024

The human central nervous system is convolutedly connected to the gut microbiome, a diverse community of microorganisms residing in gastrointestinal tract. Recent research has highlighted bidirectional communication between microbiome and neuroglial cells, which include astrocytes, microglia, oligodendrocytes, ependymal cells. These cells are essential for maintaining CNS homeostasis, supporting neuronal function, responding pathological conditions. This review examines interactions neuroglia, emphasizing their critical roles brain health development neurological disorders. Dysbiosis, or imbalance been associated with various psychiatric conditions, such as autism spectrum disorder, anxiety, depression, neurodegenerative diseases like Alzheimer’s Parkinson’s. influences function through microbial metabolites, immune modulation, neuroinflammatory responses. Understanding these paves way new therapeutic targets strategies preventing treating scoping aims highlight mechanisms microbiome-neuroglia axis its potential target.

Language: Английский

Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It? DOI Open Access

María de los Ángeles Robinson‐Agramonte,

Elena Noris García,

Jarasca Fraga Guerra

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3033 - 3033

Published: March 11, 2022

Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental disorders characterized by wide and variable set neuropsychiatric symptoms, including deficits in social communication, narrow restricted interests, repetitive behavior. The immune hypothesis considered to be major factor contributing autism pathogenesis, as well way explain the differences clinical phenotypes comorbidities influencing disease course severity. Evidence highlights link between dysfunction behavioral traits from several types evidence found both cerebrospinal fluid peripheral blood their utility identify autistic subgroups with specific immunophenotypes; underlying symptoms are also shown. This review summarizes current insights into ASD, particular reference impact immunological factors related maternal influence development; severity; others relevance, obesity. Finally, we described main elements similarities immunopathology overlapping neurodegenerative disorders, taking examples Parkinson Disease, respectively.

Language: Английский

Citations

95
The impact of maternal high-fat diet on offspring neurodevelopment DOI Creative Commons

Gintare Urbonaite,

Agne Knyzeliene,

Fanny Sophia Bunn

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: July 22, 2022

A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on their brain health and behavior. During the past three decades, obesity has rapidly increased in whole human population worldwide, including women of reproductive age. It is known that caused by a may lead to neurodevelopmental disorders offspring, such as autism spectrum disorder, attention deficit hyperactivity anxiety, depression, schizophrenia. can affect due inflammatory activation gut, adipose tissue, placenta, mirrored levels pro-inflammatory cytokines both fetal circulation. Furthermore, high fat causes gut microbial dysbiosis further contributing milieu during pregnancy lactation, thus disturbing prenatal postnatal offspring. In addition, global molecular cellular changes offspring’s occur epigenetic modifications downregulation brain-derived neurotrophic factor (BDNF) expression endocannabinoid system. These aberrations are reflected behavioral deficits observed animals, corresponding phenotypes certain humans. Here we reviewed recent findings from rodent models studies reveal potential mechanisms which interferes

Language: Английский

Citations

61
Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism DOI Creative Commons
Yu‐Chieh Chen, Hsiang‐Yuan Lin, Yi‐Ling Chien

et al.

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 106, P. 161 - 178

Published: Sept. 2, 2022

Despite inconsistent results across studies, emerging evidence suggests that the microbial micro-environment may be associated with autism spectrum disorder (ASD). Geographical and cultural factors highly impact profiles, there is a shortage of data from East Asian populations. This study aimed to comprehensively characterize profiles in an sample explore whether gut microbiota contributes clinical symptoms, emotional/behavioral problems, GI symptoms ASD.We assessed 82 boys young men ASD 31 typically developing controls (TDC), aged 6-25 years. We analyzed stool all participants 16S V3-V4 rRNA sequencing correlated its profile autistic problems.Autistic individuals, compared TDC, had worse symptoms. There were no group differences alpha diversity species richness estimates (Shannon-wiener Simpson indices). Participants increased relative abundance Fusobacterium, Ruminococcus torques (at genus level), Bacteroides plebeius DSM 17135 while decreased Ruminococcaceae UCG 013, Ervsipelotrichaceae 003, Parasutterella, Clostridium sensu stricto 1, Turicibacter spiroforme 1552 Intestinimonas butyriciproducens level). Altered taxonomic significantly thought delinquent behaviors, self dysregulation, somatic complaints. did not find association between dysbiosis.Our findings suggest altered are behavioral phenotypes but ASD. The function identified mainly involves immune pathway, supporting hypothesis complex relationship microbiome, advance discovery molecular biomarkers for

Language: Английский

Citations

49
The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders DOI Creative Commons

Francesca Damiani,

Sara Cornuti, Paola Tognini

et al.

Neuropharmacology, Journal Year: 2023, Volume and Issue: 231, P. 109491 - 109491

Published: March 15, 2023

Neuroplasticity refers to the ability of brain circuits reorganize and change properties network, resulting in alterations function behavior. It is traditionally believed that neuroplasticity influenced by external stimuli, learning, experience. Intriguingly, there new evidence suggesting endogenous signals from body's periphery may play a role. The gut microbiota, diverse community microorganisms living harmony with their host, be able influence plasticity through its modulation gut-brain axis. Interestingly, maturation microbiota coincides critical periods neurodevelopment, during which neural are highly plastic potentially vulnerable. As such, dysbiosis (an imbalance composition) early life contribute disruption normal developmental trajectories, leading neurodevelopmental disorders. This review aims examine ways can affect neuroplasticity. will also discuss recent research linking gastrointestinal issues bacterial various disorders potential impact on neurological outcomes. article part Special Issue "Microbiome & Brain: Mechanisms Maladies".

Language: Английский

Citations

38
Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders DOI Creative Commons
X. Liu, Jia Huang, Chao Song

et al.

Human & Experimental Toxicology, Journal Year: 2023, Volume and Issue: 42

Published: March 1, 2023

Recent extensive evidence suggests that ambient fine particulate matter (PM2.5, with an aerodynamic diameter ≤2.5 μm) may be neurotoxic to the brain and cause central nervous system damage, contributing neurodevelopmental disorders, such as autism spectrum neurodegenerative diseases, Alzheimer's disease Parkinson's disease, mental schizophrenia, depression, bipolar disorder. PM2.5 can enter via various pathways, including blood-brain barrier, olfactory system, gut-brain axis, leading adverse effects on CNS. Studies in humans animals have revealed PM2.5-mediated mechanisms, neuroinflammation, oxidative stress, systemic inflammation, gut flora dysbiosis, play a crucial role CNS damage. Additionally, exposure induce epigenetic alterations, hypomethylation of DNA, which contribute pathogenesis some Through literature analysis, we suggest promising therapeutic targets for alleviating PM2.5-induced neurological damage include inhibiting microglia overactivation, regulating microbiota antibiotics, targeting signaling PKA/CREB/BDNF WNT/β-catenin. several studies observed association between changes neuropsychiatric disorders. This review summarizes discusses possible mechanisms by causes neurotoxicity.

Language: Английский

Citations

26
Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway? DOI Open Access
Maria Suprunowicz,

Natalia Tomaszek,

Agata Urbaniak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 549 - 549

Published: Feb. 16, 2024

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut–brain–microbiome axis in pathogenesis ASD. Research indicates abnormal composition gut microbiome potential involvement bacterial molecules neuroinflammation brain development disruptions. Concurrently, attention directed towards short-chain fatty acids (SCFAs) intestinal tightness. This comprehensive review emphasizes impact maternal microbiota changes on autism children, especially considering immune activation (MIA). The following paper evaluates birth route colonization child with bacteria first weeks life. Furthermore, it explores pro-inflammatory cytokines, such as IL-6 IL-17a mother’s obesity potentially environmental factors purpose this to advance our understanding ASD pathogenesis, while also searching for positive implications latest therapies, probiotics, prebiotics or fecal transplantation, targeting reducing inflammation. aims provide valuable insights that could instruct future studies treatments individuals affected

Language: Английский

Citations

14
Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder DOI Creative Commons
Yousef Tizabi, Samia Bennani,

Nacer El Kouhen

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(10), P. 1549 - 1549

Published: Oct. 19, 2023

Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by persistent deficits in social interaction and communication, manifests early childhood is followed restricted stereotyped behaviors, interests, or activities adolescence adulthood (DSM-V). Although genetics environmental factors have been implicated, the exact causes of ASD yet to be fully characterized. New evidence suggests that dysbiosis perturbation gut microbiota (GM) exposure lead (Pb) may play important roles etiology. Pb toxic heavy metal has linked wide range negative health outcomes, including anemia, encephalopathy, gastroenteric diseases, and, more importantly, cognitive behavioral problems inherent ASD. can disrupt GM, which essential for maintaining overall health. consisting trillions microorganisms, shown crucial role development various physiological psychological functions. GM interacts with brain bidirectional manner referred as “Gut–Brain Axis (GBA)”. In this review, following general overview context emphasized. The potential exploitation therapeutic purposes also touched upon.

Language: Английский

Citations

22
Minocycline improves autism-related behaviors by modulating microglia polarization in a mouse model of autism DOI
Yi Luo,

Keyi Lv,

Zhulin Du

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 122, P. 110594 - 110594

Published: July 11, 2023

Language: Английский

Citations

21
Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism DOI Open Access
Elham Zahedi,

Seyed-Shahabeddin Sadr,

Ashkan Sanaeierad

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114848 - 114848

Published: May 8, 2023

Autism spectrum disorder is characterized by a variety of cellular and molecular abnormalities which leads to autism-associated behaviors. Besides behavioral defects, these individuals also suffer from various associated disorders such as gastrointestinal deficit, altered gut microbiota composition their metabolite. This study examined the effect ALC on SCFA production its effects brain inflammation in VPA autism model. After prenatal exposure valproate (600 mg/kg, i.p.) embryonic day 12.5, followed treatment (100 mg/kg during postnatal days 23–51, p.o.), ASD-like behaviors, SCFAs amount feces, intestine integrity (Occludin ZO-1 tight junction proteins), systemic (TNF-α IL-1β) were assessed. Then, Golgi-Cox staining Western blot for Iba1 protein utilized identify changes microglia profile cerebral cortex. In model, we found that induction was with demoted levels feces disintegration tissue led elevated level TNF-α plasma. Further, an increased number our histology evaluation We observed IL-1β cortex rat. All significantly alleviated treatment. Overall, findings suggest alleviation therapy model improvement SCFAs, intestinal barrier recovery brain.

Language: Английский

Citations

19
Adolescent alcohol drinking interaction with the gut microbiome: implications for adult alcohol use disorder DOI Creative Commons
Bruk Getachew, Sheketha R. Hauser, Samia Bennani

et al.

Advances in Drug and Alcohol Research, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 15, 2024

Reciprocal communication between the gut microbiota and brain, commonly referred to as “gut-brain-axis” is crucial in maintaining overall physiological homeostasis. Gut development brain maturation (neuronal connectivity plasticity) appear be synchronized follow same timeline during childhood (immature), adolescence (expansion) adulthood (completion). It important note that mesolimbic reward circuitry develops early on, whereas of inhibitory frontal cortical neurons delayed. This imbalance can lead increased acquirement reward-seeking risk-taking behaviors adolescence, consequently eventuate heightened risk for substance abuse. Thus, there high initiation alcohol drinking significantly increases use disorder (AUD) adulthood. The underlying causes AUD are not well understood. suggested alcohol-associated impairment plays a key role neurodevelopment Furthermore, alcohol-induced dysregulation microglia, either directly or indirectly through interaction with microbiota, may critical neuroinflammatory pathway leading neurodevelopmental impairments AUD. In this review article, we highlight influence adolescent on gut-brain axis eventual manifestation novel therapeutic interventions via manipulations discussed briefly.

Language: Английский

Citations

6