Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients—Randomized Controlled Trial

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1234 - 1234

Published: Feb. 28, 2023

COVID-19 symptoms vary from asymptomatic cases to moderate and severe illness with patients needing hospitalization intensive care treatment. Vitamin D is associated severity of viral infections has an immune-modulatory effect in immune response. Observational studies showed a negative association low vitamin levels mortality outcomes. In this study, we aimed determine whether daily supplementation during unit (ICU) stay affects clinically relevant Patients disease need respiratory support admitted the ICU were eligible for inclusion. randomized into one two groups: intervention group received control did not receive supplementation. total, 155 randomized: 78 77 group. There was no statistically significant difference number days spent on support, although trial underpowered main outcome. any secondary outcomes analyzed between groups. Our study suggests benefit

Language: Английский

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Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies

Journal of Bone and Mineral Research, Journal Year: 2023, Volume and Issue: 38(10), P. 1391 - 1403

Published: July 22, 2023

ABSTRACT Vitamin D plays an important role in calcium homeostasis and many cellular processes. Although vitamin supplements are widely recommended for community-dwelling adults, definitive data on whether these benefit clinically skeletal extraskeletal outcomes have been conflicting. observational studies effects of musculoskeletal may be confounded by reverse causation, randomized controlled (RCTs) Mendelian randomization (MR) can help to elucidate causation. In this review, we summarize the recent findings from large RCTs and/or MR bone health risk fractures, falls, cancer, cardiovascular disease, disorders immune system, multiple sclerosis, mortality adults. The primary analyses indicate that supplementation does not decrease loss, cancer incidence, hypertension, or generally healthy populations. Large meta-analyses suggest effect supplemental mortality. existence benefits supplementations best documented system especially people with poor status, autoimmune diseases, sclerosis. Accumulating evidence indicates reduce all-cause These findings, mostly D–replete populations, do apply older adults residential communities deficiency osteoporosis. focus should shift widespread use populations targeted select individuals, good nutritional approaches, elimination globally. © 2023 American Society Bone Mineral Research (ASBMR).

Language: Английский

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The role of vitamin D in outcomes of critical care in COVID-19 patients: evidence from an umbrella meta-analysis of interventional and observational studies

Public Health Nutrition, Journal Year: 2024, Volume and Issue: 27(1)

Published: Jan. 1, 2024

Abstract Objectives: Several meta-analyses have suggested the beneficial effect of vitamin D on patients infected with severe acute respiratory syndrome coronavirus-2. This umbrella meta-analysis aims to evaluate influence supplementation clinical outcomes and mortality rate COVID-19 patients. Design: Present study was designed as an meta-analysis. The following international databases were systematically searched till March 2023: Web Science, PubMed, Scopus, Embase. Settings: Random-effects model employed perform Using AMSTAR critical evaluation tools, methodological quality included evaluated. Participants: Adult suffering from studied. Results: Overall, 13 summarising data 4 randomised controlled trial 9 observational studies identified in this review. Our findings revealed that status significantly reduced [Interventional studies: (ES = 0·42; 95 % CI: 0·10, 0·75, P < 0·001; I 2 20·4 %, 0·285) 1·99; 1·37, 2·62, 00·0 0·944). Also, deficiency increased risk infection disease severity among Conclusion: is a factor influencing rate, severity, admission intensive care unit being detached mechanical ventilation. It vital monitor all conditions including COVID

Language: Английский

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Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1402 - 1402

Published: May 7, 2024

Since the beginning of COVID-19 pandemic, vitamin D has attracted interest due to its immunomodulatory properties. Numerous studies show a correlation between levels and cases mortality. Therefore, we conducted meta-analysis in order assess relationship D3 supplementation severity. We included 13 randomized clinical trials that contained analyzed endpoints: length hospitalization, number intensive care unit (ICU) admissions, stay ICU, requiring any supplemental oxygenation, duration overall mortality deaths associated with COVID-19. The relative risk 95% confidence interval (CI) mean difference CI were calculated compare effect. A random effects model was used calculate effect sizes. Our showed positive on ICU admission (RR = 0.73; [0.57; 0.95], p 0.02, I2 19.6%) among patients 0.56; [0.34; 0.91]; 0.02; 0%). Vitamin may potentially reduce death

Language: Английский

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The effect of vitamin D supplementation on mortality and intensive care unit admission of COVID‐19 patients. A systematic review, meta‐analysis and meta‐regression

Diabetes/Metabolism Research and Reviews, Journal Year: 2021, Volume and Issue: 38(4)

Published: Dec. 29, 2021

The aim of this systematic review and meta-analysis was to investigate the effect vitamin D supplementation on mortality admission intensive care unit (ICU) COVID-19 patients.

Language: Английский

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