The role of vitamin D in the prevention and treatment of SARS-CoV-2 infection: A meta-analysis of randomized controlled trials

Clinical Nutrition, Journal Year: 2023, Volume and Issue: 42(11), P. 2198 - 2206

Published: Sept. 20, 2023

Vitamin D (VitD) has been shown to be important for the immune response of respiratory system, but preventive and therapeutic effects vitamin supplementation on SARS-CoV-2 infection are controversial. This study aimed determine role in prevention treatment through a meta-analysis randomized controlled trials.The databases PubMed, Cochrane Library, Embase, Web Science Google Scholar were searched systematically from inception April 17,2023 identify trials involving comparison versus non-vitamin or treatment.We retrieved 25 eligible trials, including 8128 participants. Four compared infection, results (RR 0.31; 95%CI 0.07 1.32) inconclusive. Regarding with supplementation, it was found that could significantly reduce rates ICU admission 0.63; 0.44 0.89) mechanical ventilation 0.58; 0.39 0.84), had no statistically significant effect mortality. However, subgroup analyses based patients' specific conditions, reduced mortality patients deficiency 0.76; 0.58 0.98).Vitamin may have some beneficial impact severity illness caused by SARS-CoV-2, particularly VitD deficient patients, further studies still needed.

Language: Английский

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The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1345 - 1345

Published: April 29, 2024

This review aims to evaluate the efficacy of any vitamin administration(s) in preventing and managing COVID-19 and/or long-COVID. Databases were searched up May 2023 identify randomized clinical trials comparing data on effects supplementation(s) versus placebo or standard care two conditions interest. Inverse-variance random-effects meta-analyses conducted estimate pooled risk ratios (RRs) 95% confidence intervals (CIs) for all-cause mortality between supplemented non-supplemented individuals. Overall, 37 articles included: regarded long-COVID prevention 35 records management. The D contrasting. Similarly, no conclusion could be drawn multivitamins, A, B A few positive findings reported some C but results inconsistent most outcomes, excluding (RR = 0.84; CI: 0.72–0.97). Vitamin mixed aspects, including mortality, which benefits observed regular administrations only 0.67; 0.49–0.91). Despite benefits, mostly contradictory. Variety recruitment treatment protocols might explain this heterogeneity. Better-designed studies are needed clarify these vitamins’ potential against SARS-CoV-2.

Language: Английский

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Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1402 - 1402

Published: May 7, 2024

Since the beginning of COVID-19 pandemic, vitamin D has attracted interest due to its immunomodulatory properties. Numerous studies show a correlation between levels and cases mortality. Therefore, we conducted meta-analysis in order assess relationship D3 supplementation severity. We included 13 randomized clinical trials that contained analyzed endpoints: length hospitalization, number intensive care unit (ICU) admissions, stay ICU, requiring any supplemental oxygenation, duration overall mortality deaths associated with COVID-19. The relative risk 95% confidence interval (CI) mean difference CI were calculated compare effect. A random effects model was used calculate effect sizes. Our showed positive on ICU admission (RR = 0.73; [0.57; 0.95], p 0.02, I2 19.6%) among patients 0.56; [0.34; 0.91]; 0.02; 0%). Vitamin may potentially reduce death

Language: Английский

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A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through background knowledge of D, searched in Pubmed [by using key words title containing "randomized trial", "COVID-19", "vitamin (25-hydroxyvitamin cholecalciferol, calcidiol, calcifediol) supplementation"] for publications studies D/supplementation patients, especially those about randomized trials (RCTs). After reviewing these papers, did a short review pathophysiology COVID-19, summarized features 25 RCTs text tabulated table some features, commented, compared discussed differences between (for example, change serum 25-hydroxyvitamin concentration from nmol/L to ng/mL, making comparison easier). The take-home question that an important indicator effect correction but may not be reliable predicting outcomes COVID-19.

Language: Английский

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The impact of supplementing vitamin D through different methods on the prognosis of COVID-19 patients: a systematic review and meta-analysis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

To analyze the impact of different methods Vitamin D administration on prognosis COVID-19 patients.

Language: Английский

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Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 249 - 271

Published: Nov. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Language: Английский

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The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 3205 - 3212

Published: Sept. 3, 2024

Language: Английский

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Evaluation of Vitamin D Supplementation in Critically Ill Patients—A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 816 - 816

Published: Feb. 27, 2025

The prevalence of vitamin D deficiency among intensive care unit (ICU) patients is potentially associated with an increased risk mechanical ventilation, sepsis, prolonged hospital stays, and mortality. Although ICU patient has significantly improved in recent years, the role supplementation remains under investigation. A literature review was conducted using PubMed, Web Science, Embase, Cochrane databases, focusing on randomized controlled trials published past five years adult patients. Patients' baseline levels, administration routes, doses, biomarker changes, ventilation duration, length stay, mortality were analyzed. appears safe may reduce stay duration time improve SOFA scores, its impact overall uncertain. Routine for all not currently recommended; clinical decisions should consider individual characteristics, severity illness, methods.

Language: Английский

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Vitamin D: A Nutraceutical Supplement at the Crossroad Between Respiratory Infections and COVID-19

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2550 - 2550

Published: March 12, 2025

Even though in mid-2023 the World Health Organization declared end of public health emergency international concern status for COVID-19, many areas uncertainty about SARS-CoV-2 infection pathophysiology remain. Although last 4 years pharmaceutical industries widely invested development effective antiviral treatments and vaccines, large disparities their availability worldwide still exist, thus fostering investigation nutritional supplements as adjuvant therapeutic approaches disease management, especially resource-limited settings. During COVID-19 pandemic, vitamin D has been used an over-the-counter solution to improve evolution, thanks its known immunomodulatory anti-inflammatory actions. Ecological observational studies support a relationship between hypovitaminosis negative outcomes and, according this evidence, several research groups investigated role supplementation protecting from and/or improving evolution. This narrative review is intended offer insights into existing data on D’s biological effects respiratory infections, COVID-19. Furthermore, it will also brief overview complex interplay vaccine-elicited immune response, with special attention anti-COVID-19 vaccines.

Language: Английский

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Vitamin D supplementation for managing COVID-19 in patients with vitamin D deficiency: a systematic review and meta-analysis of randomised controlled trials

BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e091903 - e091903

Published: March 1, 2025

Objectives Vitamin D deficiency is prevalent among the population. Previous studies have shown that vitamin supplementation might be useful for treating COVID-19 infection. Therefore, we performed a meta-analysis to explore efficacy in patients with deficiency. Design Systematic review and Data sources PubMed, Cochrane Library, Embase Web of Science. Eligibility criteria Randomised controlled trials exploring extraction synthesis Two independent reviewers employed standardised methods search, screen code included studies. The primary outcomes mortality during follow-up, 28-day mortality, need mechanical ventilation intensive care unit (ICU). secondary outcome length stay hospital ICU. risk bias was assessed using Risk Bias 2 tool. Depending on level heterogeneity, either random-effects model or fixed-effects applied. findings were summarised Grading Recommendations Assessment, Development Evaluation (GRADE) evidence profiles synthesised qualitatively. Results A total nine studies, comprising 870 participants, analysis. pooled results indicated associated lower (risk ratio 0.76; 95% CI 0.60 0.97). However, this apparent benefit not robust when examined through leave-one-out method trial sequential Regarding other outcomes, there no statistically significant difference between terms ICU admission. 0.41 day shorter (mean −0.41; −1.09 0.28) 0.07 −0.07; −0.61 0.46) compared supplementation; however, neither significant. Conclusion Based low moderate quality, reduced rate follow-up it did improve nor reduce admission, hospital. PROSPERO registration number CRD42024573791.

Language: Английский

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