A Nationwide Analysis of the Impact of Vasculopathies on COVID-19 Hospitalization Outcomes DOI Creative Commons

Sean A. Na,

Ayush Sangari, James R. Pellegrini

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 25, 2023

Abstract Background and Aims : The study investigated the short-term outcomes of COVID-19 in conjunction with vasculopathies, including vasculitides, for inpatient hospitalization encounters. Methods 2020 National Inpatient Sample was used to identify hospitalizations presenting a primary admitting diagnosis without secondary vasculopathy, vasculitides. interest were mortality mechanical ventilation use vasculopathies. Secondary in-hospital length stay hospital charges. Results A total 1,050,040 weighted included this principal COVID-19. Among population, 1,440 had concurrent 1,048,600 vasculopathy. Positive associations regarding found Kawasaki disease (aOR 7.9115, 95% CI [1.4612 - 42.8362]; p = 0.0164), microscopic polyangiitis 3.5589, [1.1356 11.1529]; 0.0295), thrombotic microangiopathy 3.9213, [2.1959 7.0027]; 4.00E-06), other specified necrotizing vasculitis 20.9423, [4.5566 96.2510]; 9.44E-05), unspecified vasculopathy 16.6108 , [2.0106 137.2299]; 0.0091), cryoglobulinemia 8.5863 [2.2848 32.2669]; 0.0015). 7.4010, [2.9088 18.8311]; 2.72E-05), 3.5112, [2.1457 5.7459]; 6.06E-07), 34.9851, [6.5912 185.6968]; 3.06E-05), 18.3357, [2.2010 152.7467]; 0.0072). Additionally, relative difference 53% higher vasculopathies than those (RD 1.53, [1.35 1.74]; 6.18E-11); similarly, charges 97% 1.97, [1.58 2.46]; 2.18E-09). Conclusion This demonstrates significantly odds morbidity among substantiating previous claims literature.

Language: Английский

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on DOI Creative Commons
Chrysoula Boutari, Christos S. Mantzoros

Metabolism, Journal Year: 2022, Volume and Issue: 133, P. 155217 - 155217

Published: May 15, 2022

The WHO just released in May 2022 a report on the state of obesity pandemic Europe, stating that 60% citizens area Europe are either overweight or obese, and highlighting implications pandemic, especially as it interacts with COVID to create twin increase morbidity mortality. Obesity is complex disease which has reached dimensions. worldwide prevalence nearly tripled since 1975, mainly due adoption progressively more sedentary lifestyle consumption less healthy diets. We first herein updated rates by sex, age, region per report, then between 1980 2019, we analyze present data provided Global Burden Disease Study. higher women than men any age both increases their highest point ages 50 65 years showing slight downward trend afterwards. age-standardized increased from 4.6% 14.0% 2019. American European have USA Russia countries most obese residents. Given dire terms comorbidities mortality, these epidemiological findings call for coordinated actions local regional governments, scientific community individual patients alike, well food industry be controlled alleviated. can hopefully learn COVID-19 where collaborative efforts worldwide, focused intense work at global level well-coordinated leadership demonstrated humankind capable amazing accomplishments leveraging science public health, finally make strides understanding combating its including diabetes, NAFLD, CVD associated malignancies.

Language: Английский

Citations

665
Comorbidities, multimorbidity and COVID-19 DOI Open Access
Clark D Russell, Nazir Lone, J. Kenneth Baillie

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(2), P. 334 - 343

Published: Feb. 1, 2023

Language: Английский

Citations

257
Bidirectional causal associations between type 2 diabetes and COVID‐19 DOI
Hongbao Cao, Ancha Baranova,

Xuejuan Wei

et al.

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Aug. 27, 2022

Abstract Observational studies have reported high comorbidity between type 2 diabetes (T2D) and severe COVID‐19. However, the causality T2D COVID‐19 has yet to be validated. We performed genetic correlation Mendelian randomization (MR) analyses assess relationships potential causal associations three outcomes (severe acute respiratory syndrome coronavirus [SARS‐CoV‐2] infection, hospitalization, critical COVID‐19). Molecular pathways connecting SARS‐CoV‐2 were reconstructed extract insights into mechanisms underlying connection. identified a overlap each outcome (genetic correlations 0.21–0.28). The MR indicated that liability confers effect on hospitalized (odds ratio 1.08, 95% confidence interval [CI] 1.04–1.12) (1.09, 1.03–1.16), while infection exerts (1.25, 1.00–1.56). There was suggestive evidence associated with an increased risk for (1.02, 1.00–1.03), (1.06, 1.00–1.13) 0.99–1.19) T2D. Pathway analysis panel of immunity‐related genes may mediate links at molecular level. Our study provides robust support bidirectional contribute amplifying severity COVID‐19, increase

Language: Английский

Citations

72
SARS-CoV-2 immunity in animal models DOI Creative Commons
Chen Zhao,

Yaochang Yuan,

Qing‐Tao Hu

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(2), P. 119 - 133

Published: Jan. 18, 2024

The COVID-19 pandemic, which was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its transmissibility. SARS-CoV-2 infection results in illness and can lead significant complications affected individuals. These encompass symptoms such as coughing, distress, fever, infectious shock, distress (ARDS), even multiple-organ failure. Animal models serve crucial tools for investigating pathogenic mechanisms, immune responses, escape antiviral drug development, vaccines against SARS-CoV-2. Currently, various animal infection, nonhuman primates (NHPs), ferrets, hamsters, many different mouse models, have been developed. Each model possesses distinctive features applications. In this review, we elucidate the response elicited patients provide an overview of characteristics mainly used well corresponding responses applications these models. A comparative analysis transcriptomic alterations lungs from revealed that K18-hACE2 mouse-adapted virus exhibited highest similarity with deceased patients. Finally, highlighted current gaps related research between studies clinical investigations, underscoring lingering scientific questions demand further clarification.

Language: Английский

Citations

18
The impact of obesity: a narrative review DOI Creative Commons

Benjamin Chih Chiang Lam,

Amanda Yuan Ling Lim,

Soo Ling Chan

et al.

Singapore Medical Journal, Journal Year: 2023, Volume and Issue: 64(3), P. 163 - 171

Published: Feb. 28, 2023

Obesity is a disease with major negative impact on human health. However, people obesity may not perceive their weight to be significant problem and less than half of patients are advised by physicians lose weight. The purpose this review highlight the importance managing overweight discussing adverse consequences obesity. In summary, strongly related >50 medical conditions, many them having evidence from Mendelian randomisation studies support causality. clinical, social economic burdens considerable, these potentially impacting future generations as well. This highlights health an urgent concerted effort towards prevention management reduce burden

Language: Английский

Citations

39
The causal role of gut microbiota in susceptibility and severity of COVID‐19: A bidirectional Mendelian randomization study DOI
Han Chen, Bixing Ye,

Wei Su

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(7)

Published: July 1, 2023

Growing evidence has shown that altered gut microbiota is associated with the pathogenesis of COVID-19, but their causal effects are still unclear. We conducted a bidirectional Mendelian randomization (MR) study to assess on COVID-19 susceptibility or severity, and vice versa. The microbiome genome-wide association studies (GWAS) data 18 340 individuals GWAS statistics from host genetics initiative (38 984 European patients 1 644 784 controls) were used as exposure outcomes. inverse variance weighted (IVW) was primary MR analysis. Sensitivity analyses performed validate robustness, pleiotropy, heterogeneity results. In forward MR, we identified several microbial genera (p < 0.05 FDR 0.1): Alloprevotella (odds ratio [OR]: 1.088, 95% confidence interval [CI]: 1.021-1.160), Coprococcus (OR: 1.159, CI: 1.030-1.304), Parasutterella 0.902, 0.836-0.973), Ruminococcaceae UCG014 0.878, 0.777-0.992). Reverse had depletion families Lactobacillaceae (Beta [SE]: -0.220 [0.101]) Lachnospiraceae (-0.129 [0.062]), Flavonifractor (-0.180 [0.081]) Lachnoclostridium [-0.181 [0.063]). Our findings supported effect infection might further causally induce dysbiosis.

Language: Английский

Citations

14
Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank DOI Creative Commons

A. Lee,

Ji-Eun Seo,

Seunghwan Park

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Jan. 24, 2024

Abstract Type 2 diabetes (T2D) is known as one of the important risk factors for severity and mortality COVID-19. Here, we evaluate impact T2D its genetic susceptibility on COVID-19, using 459,119 individuals in UK Biobank. Utilizing polygenic scores (PRS) T2D, identified a significant association between or PRS, COVID-19 severity. We further discovered efficacy vaccination pivotal role T2D-related genetics pathogenesis severe Moreover, found that with those high PRS group had significantly increased rate. also observed rate SARS-CoV-2-infected patients was approximately to 7 times higher than not infected, depending time infection. These findings emphasize potential estimating

Language: Английский

Citations

6
Iron, selenium, copper and magnesium in critical care: Impact on acquired weakness risk through Mendelian randomization DOI
Li Zhang,

H. Sun,

Yuwei Sun

et al.

Nursing in Critical Care, Journal Year: 2025, Volume and Issue: 30(3)

Published: May 1, 2025

Abstract Background Trace elements play a crucial role in the health of critically ill patients, yet their impact on acquired weakness remains unclear. Aim This study utilized Mendelian randomization (MR) to explore relationship between iron, selenium, copper, magnesium, zinc and debilitation risk this population. The aim was investigate influence specific trace patients determine protective or effects. Study Design project collected total 164 627 exposure related datasets 4 518 732 outcome datasets. employed analyse data assessing how magnesium may risk. Results explored causal relationships (iron, zinc, selenium magnesium) outcomes (muscle dysfunction, muscle damage respiratory infections) patients. For example, analysis iron (ukb‐b‐20 447) diaphragmatic hernia (ukb‐b‐8848) using Inverse Variance Weighted (IVW) method showed an odds ratio (OR) 0.996 (95% CI: 0.993–0.999, p = .004). Overall, MR results indicated that are factors, while copper factors for weakness. Zinc not causally associated with Conclusions highlights importance understanding among providing valuable insights personalized care strategies enhance patient outcomes. Relevance Clinical Practice findings offer new theoretical foundations potential molecular targets prevention treatment critical settings.

Language: Английский

Citations

0
Investigating the shared genetic architecture between COVID-19 and obesity: a large-scale genome wide cross-trait analysis DOI Creative Commons
Yanjing Chen,

Chunhua Fan,

Jun Liu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 30, 2024

Observational studies have reported high comorbidity between obesity and severe COVID-19. The aim of this study is to explore whether genetic factors are involved in the co-occurrence two traits. Based on available genome-wide association (GWAS) summary statistics, we explored correlation performed cross-trait meta-analysis (CPASSOC) colocalization analysis (COLOC) detect pleiotropic single nucleotide polymorphisms (SNPs). At level, obtained genes detected by Functional mapping annotation (FUMA) Multi-marker Analysis GenoMic Annotation (MAGMA). Potential functional were further investigated summary-data-based Mendelian randomization (SMR). Finally, casualty was identiied using latent causal variable model (LCV). A significant positive revealed We found 331 shared SNPs CPASSOC 13 risk loci COLOC. 3546 genes, among which 107 be significantly expressed SMR. Lastly, observed these mainly enriched immune pathways signaling transduction. These indings could provide new insights into etiology implications for future therapeutic trial.

Language: Английский

Citations

1
The Prognostic Value of Olfactory Dysfunction in Patients with COVID-19: The COVIDORA Study DOI Creative Commons

Anne-Laure Hamel,

Léo Delbos,

Pierre-André Natella

et al.

Life, Journal Year: 2024, Volume and Issue: 14(3), P. 293 - 293

Published: Feb. 22, 2024

Background: Among all studies describing COVID-19 clinical features during the first wave of pandemic, only a few retrospective have assessed correlation between olfac-tory dysfunction (OD) and evolution disease severity. The main aim was to assess whether OD is predictive factor severity based on patient’s medical management (outpa-tient care, standard hospital admission, ICU admission). Methods: A national, prospective, mul-ticenter cohort study conducted in 20 public hospitals center for screen-ing. During from 6 April 11 May 2020, patients tested positive confirmed by RT-PCR underwent two follow-up ENT consultations within 10 days symptom onset. outcome measures were (out-patient admission) at diagnosis along course disease. Results: 481 included, prevalence 60.7%, it affected mostly female (74.3%) under 65 years old (92.5%), with fewer comor-bidities than normal olfactory function. Here, 99.3% (290/292) presented non-severe Patients reporting significantly less hospi-talized ones managed as outpatients, either unit or an ICU. Conclu-sions: As regards disease, could predict decreased risk hospitalization pandemic.

Language: Английский

Citations

1