SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation DOI Creative Commons

Shengyu Pan,

Tianhui Yuan,

Yuqi Xia

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2279 - 2279

Published: Oct. 8, 2024

: Damage to renal tubular cells (RTCs) represents a critical pathological manifestation in calcium oxalate (CaOx) stone disease, but the underlying mechanism remains elusive. Energy metabolism reprogramming is vital influencer of RTC survival, and SMYD2 histone methylation transferase that has been extensively implicated various metabolic disorders. Hence, this research aimed identify whether induces energy RTCs exposed CaOx nephrolithiasis.

Language: Английский

Lactate and lactylation in cardiovascular diseases: current progress and future perspectives DOI
Wengen Zhu,

Siyu Guo,

Junyi Sun

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 158, P. 155957 - 155957

Published: June 21, 2024

Language: Английский

Citations

17
The metabolic pathway regulation in kidney injury and repair DOI Creative Commons
Wenbin Tang, Qingqing Wei

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 12, 2024

Kidney injury and repair are accompanied by significant disruptions in metabolic pathways, leading to renal cell dysfunction further contributing the progression of pathology. This review outlines complex involvement various energy production pathways glucose, lipid, amino acid, ketone body metabolism within kidney. We provide a comprehensive summary aberrant regulation these kidney repair. After acute (AKI), there is notable mitochondrial damage oxygen/nutrient deprivation, reduced activity glycolysis bioenergetics. Additionally, occur pentose phosphate pathway (PPP), acid metabolism, supply bodies. The subsequent phase characterized shift toward glycolysis, along with decreased fatty β-oxidation continued disturbances metabolism. Furthermore, impact on injury, regeneration, development fibrosis analyzed. Finally, we discuss potential therapeutic strategies targeting ameliorate promote

Language: Английский

Citations

9
Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation‐Mediated FGFR4 Activation DOI Creative Commons
Zehua Ye,

Yushi Sun,

Songyuan Yang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract The incidence of kidney stones is increasing worldwide. However, the underlying mechanism process stone formation and damage caused are not well understood. Here, it observed that Lgals3, a β‐galactoside‐binding protein, significantly increased in tissues with calcium oxalate (CaOx) stones, both vivo vitro models. Lgals3 expression positively correlated deposition CaOx crystals. Knockout markedly reduces crystal renal fibrosis vivo. Furthermore, deficiency decrease glycolytic rate lactate production during inhibited histone lactylation H3K18la. Mechanistic studies shows directly interacted key glycolysis protein pyruvate kinase M2 (PKM2) promoted its by modulating E3 ligase Trim21, preventing ubiquitination PKM2. H3K18 injury vitro. inhibites transcription, activation, FGFR4 through inhibition These findings suggest may play role interacting PKM2 promoting H3K18la‐mediated gene transcription activation.

Language: Английский

Citations

1
Pyruvate kinase M2 regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease DOI Creative Commons
Yulan Chen, Xueyuan Bai, Jianwen Chen

et al.

Cell Proliferation, Journal Year: 2023, Volume and Issue: 57(2)

Published: Sept. 25, 2023

Abstract We aimed to investigate the role of renal pericyte pyruvate kinase M2 (PKM2) in progression acute kidney injury (AKI) chronic disease (CKD). The PKM2 pericyte‐myofibroblast transdifferentiation was investigated an AKI‐CKD mouse model. Platelet growth factor receptor beta (PDGFRβ)‐iCreERT2; tdTomato mice were used for tracing. Western blotting and immunofluorescence staining examine protein expression. An 5‐ethynyl‐2′‐deoxyuridine assay measure proliferation. A scratch cell migration analyse migration. Seahorse experiments glycolytic rates. Enzyme‐linked immunoassay enzymatic activity lactate concentrations. nuclear translocation inhibitors Shikonin TEPP‐46 alter transdifferentiation. In AKI‐CKD, pericytes proliferated transdifferentiated into myofibroblasts is highly expressed pericytes. inhibited proliferation, migration, by reducing entry. nucleus, promoted downstream dehydrogenase (LDHA) glucose transporter 1 (GLUT1) transcription, which are critical glycolysis. Therefore, regulates production, PKM2‐regulated regulating LDHA GLUT1 transcription production. Reducing import can reduce pericytes‐myofibroblasts transdifferentiation, providing new ideas treatment.

Language: Английский

Citations

17
Metabolic reprogramming in septic acute kidney injury: pathogenesis and therapeutic implications DOI
Caihong Liu, Wei Wei, Yongxiu Huang

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 158, P. 155974 - 155974

Published: July 10, 2024

Language: Английский

Citations

8
Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target DOI

Ya-Na Yang,

Mao-Qing Zhang,

Feng-Lin Yu

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 215, P. 115717 - 115717

Published: July 28, 2023

Language: Английский

Citations

16
Advances in metabolic reprogramming of renal tubular epithelial cells in sepsis-associated acute kidney injury DOI Creative Commons

Tiantian Wang,

Ying Huang, Xiaobei Zhang

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 19, 2024

Sepsis-associated acute kidney injury presents as a critical condition characterized by prolonged hospital stays, elevated mortality rates, and an increased likelihood of transition to chronic disease. suppresses fatty acid oxidation oxidative phosphorylation in the mitochondria renal tubular epithelial cells, thus favoring metabolic shift towards glycolysis for energy production. This acts protective mechanism kidneys. However, extended reliance on may contribute atrophy, fibrosis, subsequent disease progression. Metabolic reprogramming interventions have emerged prospective strategies counteract sepsis-associated restoring normal function, offering potential therapeutic preventive modalities. review delves into alterations cells associated with injury, stressing importance immune response urgency normalization. We present various intervention targets that could facilitate recovery phosphorylation-centric metabolism. These novel insights aim transform clinical prevention treatment landscape focus mechanisms. investigation provide valuable clinicians aiming enhance patient outcomes context injury.

Language: Английский

Citations

4
PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis DOI Creative Commons

Wenxiang Chu,

Weilin Peng, Yingying Lü

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(40)

Published: Aug. 9, 2024

Abstract Epigenetic regulation of metabolism profoundly influences cell fate commitment. During osteoclast differentiation, the activation RANK signaling is accompanied by metabolic reprogramming, but epigenetic mechanisms which induces this reprogramming remain elusive. By transcriptional sequence and ATAC analysis, study identifies that upregulates PRMT6 modification, triggering a switching from fatty acids oxidation toward glycolysis. Conversely, Prmt6 deficiency reverses shift, markedly reducing HIF‐1α‐mediated glycolysis enhancing acid oxidation. Consequently, or inhibitor impedes differentiation alleviates bone loss in ovariectomized (OVX) mice. At molecular level, reduces asymmetric dimethylation H3R2 at promoters genes including Ppard , Acox3 Cpt1a genomic accessibility for thus emerges as checkpoint, mediating switch to glycolysis, thereby supporting osteoclastogenesis. Unveiling PRMT6's critical role epigenetically orchestrating shifts osteoclastogenesis offers promising target anti‐resorptive therapy.

Language: Английский

Citations

4
TRIM21 knockout alleviates renal fibrosis by promoting autophagic degradation of mature TGF-β1 DOI Creative Commons
Peng Li,

Xinyi Dong,

XU Lijun

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 234, P. 116822 - 116822

Published: Feb. 19, 2025

Language: Английский

Citations

0
Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation DOI

Lingkun Wang,

Yaochen Xie,

Boneng Xiao

et al.

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 212, P. 22 - 33

Published: Dec. 13, 2023

Language: Английский

Citations

10