Nomogram-based prognostic stratification for patients with large hepatocellular carcinoma: a population study of SEER database and a Chinese cohort DOI Open Access
Kun Ji, Hanlong Zhu, Cong Zhang

et al.

Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 15(5), P. 2201 - 2215

Published: Oct. 1, 2024

Large hepatocellular carcinoma (HCC) with a diameter ≥5 cm remains significant challenge of poor survival and raises the need for prognosis evaluation. This study aimed to develop validate nomogram-based prognostic stratification assess overall (OS) patients large HCC.

Language: Английский

Aspartame increases the risk of liver cancer through CASP1 protein: A comprehensive network analysis insights DOI

N. Li,

Yixuan Zeng, Yufeng Gu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118089 - 118089

Published: March 26, 2025

Language: Английский

Citations

1
Structure, function, signaling pathways and clinical therapeutics: The translational potential of STAT3 as a target for cancer therapy DOI
Dandan Shi,

Jiejing Tao,

Shuli Man

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189207 - 189207

Published: Nov. 1, 2024

Language: Английский

Citations

7
Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis DOI
Waleed Hassan Almalki, Salem Salman Almujri

Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 15, 2024

Language: Английский

Citations

4
PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating NF-κB/IL-6/STAT3-dependent TCA cycle DOI Creative Commons
Chengfei Zhang,

Yangchun Zhou,

Minghua Hu

et al.

JHEP Reports, Journal Year: 2025, Volume and Issue: 7(5), P. 101329 - 101329

Published: Jan. 20, 2025

Language: Английский

Citations

0
Neem leaf extract alleviates LPS/D-GalN induced acute hepatitis in mice through its anti-inflammatory effects and activation of autophagy DOI

Meiyu Jin,

L V Mengfan,

Hao Yu

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 180, P. 33 - 43

Published: Feb. 24, 2025

Language: Английский

Citations

0
Non-immune targeting of CXCR3 compromises mitochondrial function and suppresses tumor growth in glioblastoma DOI Creative Commons

Travis Yui Hei Chan,

Bo Chen,

Wanjun Tang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 4, 2025

Abstract The chemokine receptor CXCR3 is traditionally recognized for its role in immune cell trafficking. However, emerging evidence suggests that functions may extend beyond the system, particularly cancer, where roles remain to be elucidated. In this study, we demonstrated expression correlates with glioblastoma (GBM) grading, CXCR3-A isoform being associated poorer patient prognosis compared CXCR3-B. Ablation of both isoforms significantly impaired GBM proliferation, migration, and tumor growth vitro immunodeficient mice. To elucidate mechanistic CXCR3, conducted transcriptomic profiling xenografts, revealing depletion would disrupt mitochondrial homeostasis. This was further supported by our findings localize membrane, inhibition lead depolarization increased reactive oxygen species production. Notably, activation phosphorylated-STAT3 rescued viability CXCR3-depleted cells, suggesting modulate function through a STAT3-dependent mechanism, consistent known functional STAT3 maintaining redox balance. Furthermore, treatment selective antagonist AMG487 reduced disrupted vitro, vivo, patient-derived stem cells. Our reveal as previously unrecognized regulator cancer positioning CXCR3-mitochondrial signaling axis promising therapeutic target GBM.

Language: Английский

Citations

0
Solanum nigrum Toxicity and Its Neuroprotective Effect Against Retinal Ganglion Cell Death Through Modulation of Extracellular Matrix in a Glaucoma Rat Model DOI

Karan Singh Yadav,

Amol Chhatrapati Bisen, Sharmeen Ishteyaque

et al.

Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2024, Volume and Issue: 40(5), P. 309 - 324

Published: April 11, 2024

Glaucoma is a complex degenerative optic neuropathy characterized by loss of retinal ganglion cells (RGCs) leading to irreversible vision and blindness.

Language: Английский

Citations

3
The Genetically Predicted Causal Associations Between Circulating 3-Hydroxybutyrate Levels and Malignant Neoplasms: A Pan-cancer Mendelian Randomization Study DOI Creative Commons

Fanghang Ye,

Yucheng Huang,

Liang Zeng

et al.

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(11), P. 137 - 152

Published: Oct. 1, 2024

Language: Английский

Citations

3
Silencing PCK1 mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission DOI Creative Commons
Li Zhang, Yingmei Chen,

Quanrong Pan

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

The pathological proliferation and migration of vascular smooth muscle cells (VSMCs) are key processes during neointimal hyperplasia (NIH) restenosis. Phosphoenolpyruvate carboxy kinase 1 (PCK1) is closely related to a variety malignant proliferative diseases. However, the role PCK1 in VSMCs has rarely been investigated. This study aims examine NIH after injury.

Language: Английский

Citations

0
Nomogram-based prognostic stratification for patients with large hepatocellular carcinoma: a population study of SEER database and a Chinese cohort DOI Open Access
Kun Ji, Hanlong Zhu, Cong Zhang

et al.

Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 15(5), P. 2201 - 2215

Published: Oct. 1, 2024

Large hepatocellular carcinoma (HCC) with a diameter ≥5 cm remains significant challenge of poor survival and raises the need for prognosis evaluation. This study aimed to develop validate nomogram-based prognostic stratification assess overall (OS) patients large HCC.

Language: Английский

Citations

0