Environmental factors influencing the development and spread of antibiotic resistance

FEMS Microbiology Reviews, Journal Year: 2017, Volume and Issue: 42(1)

Published: Oct. 19, 2017

Antibiotic resistance and its wider implications present us with a growing healthcare crisis. Recent research points to the environment as an important component for transmission of resistant bacteria in emergence pathogens. However, deeper understanding evolutionary ecological processes that lead clinical appearance genes is still lacking, knowledge environmental dispersal barriers. This calls better models how evolve, are mobilized, transferred disseminated environment. Here, we attempt define factors contribute development transmission. Although mobilization likely occurs continuously, great majority such genetic events do not establishment novel bacterial populations, unless there selection pressure maintaining them or their fitness costs negligible. To enable preventative measures it therefore critical investigate under what conditions extent takes place. In addition, barriers only key evaluate risks, but also prevent pathogens, well genes, from reaching humans.

Language: Английский

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Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence

Science Advances, Journal Year: 2019, Volume and Issue: 5(3)

Published: March 1, 2019

The antibiotic resistome in European UWTPs mirrors the gradient of north-to-south clinical resistance prevalence.

Language: Английский

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Plant growth promoting bacteria in agriculture: Two sides of a coin

Applied Soil Ecology, Journal Year: 2019, Volume and Issue: 138, P. 10 - 18

Published: March 2, 2019

Language: Английский

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Microbial mass movements

Science, Journal Year: 2017, Volume and Issue: 357(6356), P. 1099 - 1100

Published: Sept. 14, 2017

Wastewater, tourism, and trade are moving microbes around the globe at an unprecedented scale

Language: Английский

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Amikacin: Uses, Resistance, and Prospects for Inhibition

Molecules, Journal Year: 2017, Volume and Issue: 22(12), P. 2267 - 2267

Published: Dec. 19, 2017

Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat broad spectrum bacterial infections. The primary resistance mechanism against these is enzymatic modification by aminoglycoside-modifying enzymes that divided into acetyl-transferases, phosphotransferases, and nucleotidyltransferases. To overcome this problem, new semisynthetic aminoglycosides were developed in 70s. most widely aminoglycoside amikacin, which refractory modifying enzymes. Amikacin was synthesized acylation with l-(−)-γ-amino-α-hydroxybutyryl side chain at C-1 amino deoxystreptamine moiety kanamycin A. main amikacin found clinics acetylation 6′-N-acetyltransferase type Ib [AAC(6′)-Ib], an enzyme coded for gene integrons, transposons, plasmids, chromosomes Gram-negative bacteria. Numerous efforts focused on finding strategies neutralize action AAC(6′)-Ib extend useful life amikacin. Small molecules as well complexes ionophore-Zn+2 or Cu+2 inhibit reaction induced phenotypic conversion susceptibility bacteria harboring aac(6′)-Ib gene. A aminoglycoside, plazomicin, advance stage development will contribute renewed interest kind antibiotics.

Language: Английский

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Microbial evolution through horizontal gene transfer by mobile genetic elements

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 1, 2024

Mobile genetic elements (MGEs) are crucial for horizontal gene transfer (HGT) in bacteria and facilitate their rapid evolution adaptation. MGEs include plasmids, integrative conjugative elements, transposons, insertion sequences bacteriophages. Notably, the spread of antimicrobial resistance genes (ARGs), which poses a serious threat to public health, is primarily attributable HGT through MGEs. This mini-review aims provide an overview mechanisms by mediate microbes. Specifically, behaviour plasmids different environments conditions was discussed, recent methodologies tracing dynamics were summarised. A comprehensive understanding underlying role bacterial adaptation important develop strategies combat ARGs.

Language: Английский

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Discovery of the fourth mobile sulfonamide resistance gene

Microbiome, Journal Year: 2017, Volume and Issue: 5(1)

Published: Dec. 1, 2017

Over the past 75 years, human pathogens have acquired antibiotic resistance genes (ARGs), often from environmental bacteria. Integrons play a major role in acquisition of genes. We therefore hypothesized that focused exploration integron gene cassettes microbial communities could be an efficient way to find novel mobile DNA polluted Indian river sediments were amplified using three sets primers targeting class 1 integrons and sequenced by long- short-read technologies maintain both accuracy context.Up 89% identified open reading frames encode known genes, or variations thereof (> 1000). putative ARGs aminoglycosides, beta-lactams, trimethoprim, rifampicin, chloramphenicol, including several OXA variants, providing reduced susceptibility carbapenems. One dihydropteroate synthase gene, with less than 34% amino acid identity sulfonamide (sul1-3), provided complete when expressed Escherichia coli. The mobilized here named sul4, is first discovered since 2003. Analyses adjacent suggest sul4 has been decontextualized set chromosomal involved folate synthesis its original host, likely within phylum Chloroflexi. presence insertion sequence common region element provide mobility entire integron. Screening 6489 metagenomic datasets revealed already widespread seven countries across Asia Europe.Our findings show exploring history exposure can novel, mobilization fourth expanded opportunities for spread, potential impacts on animal health.

Language: Английский

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Horizontal gene transfer and shifts in linked bacterial community composition are associated with maintenance of antibiotic resistance genes during food waste composting

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 660, P. 841 - 850

Published: Dec. 26, 2018

Language: Английский

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The abundance and diversity of antibiotic resistance genes in the atmospheric environment of composting plants

Environment International, Journal Year: 2018, Volume and Issue: 116, P. 229 - 238

Published: April 24, 2018

Language: Английский

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Conserved phylogenetic distribution and limited antibiotic resistance of class 1 integrons revealed by assessing the bacterial genome and plasmid collection

Microbiome, Journal Year: 2018, Volume and Issue: 6(1)

Published: July 21, 2018

Integrons, especially the class 1 integrons, are major contributors to acquisition and dissemination of antibiotic resistance genes (ARGs). However, comprehensive knowledge types, content, distribution integrons in bacterial taxa is lacking evaluate their contribution.We have constructed a new integrase database developed pipeline that provides recovery integrons. Previous PCR-based techniques might only detect one fourth integron-integrases recovered this study. By exploring over 73,000 currently available complete draft genomes, contribution spreading acquiring ARGs was evaluated. Firstly, host species highly conserved within (96%) Gammaproteobacteria, dominated by four pathogenic "ESKAPE." Secondly, more than half embedded chromosomes with less potential for horizontal gene transfer. Finally, been acquired these cover 11% all ARG genotypes detected genomes.The above observations indicated there both biological ecological limitations across different classes domain Bacteria.

Language: Английский

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