Good microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome DOI Creative Commons

Alexander Crits‐Christoph,

Haley Hallowell, Kalia Koutouvalis

et al.

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: March 25, 2022

A global rise in antimicrobial resistance among pathogenic bacteria has proved to be a major public health threat, with the rate of multidrug-resistant bacterial infections increasing over time. The gut microbiome been studied as reservoir antibiotic genes (ARGs) that can transferred pathogens via horizontal gene transfer (HGT) conjugative plasmids and mobile genetic elements (the resistome). Advances metagenomic sequencing have facilitated identification resistome modulators, including live microbial therapeutics such probiotics fecal transplantation either expand or reduce abundances ARG-carrying gut. While many different microbes encode for ARGs, they are not uniformly distributed across, transmitted by, various members microbiome, all equal clinical relevance. Both experimental theoretical approaches ecology applied understand differing frequencies ARG between commensal well commensals pathogens. In this commentary, we assess evidence role encoding genes, degree which shared both other pathogens, host environmental factors impact dynamics. We further discuss novel sequencing-based identifying ARGs predicting future events clinically relevant from

Language: Английский

Antibiotic resistance in the environment DOI Open Access
D. G. Joakim Larsson, Carl‐Fredrik Flach

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(5), P. 257 - 269

Published: Nov. 4, 2021

Language: Английский

Citations

1738
A review of the global climate change impacts, adaptation, and sustainable mitigation measures DOI Open Access

Kashif Abbass,

Muhammad Qasim, Huaming Song

et al.

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(28), P. 42539 - 42559

Published: April 4, 2022

Language: Английский

Citations

1221
Defining and combating antibiotic resistance from One Health and Global Health perspectives DOI
Sara Hernando‐Amado, Teresa M. Coque, Fernando Baquero

et al.

Nature Microbiology, Journal Year: 2019, Volume and Issue: 4(9), P. 1432 - 1442

Published: Aug. 22, 2019

Language: Английский

Citations

902
Occurrence and fate of antibiotics, antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARB) in municipal wastewater treatment plant: An overview DOI
Jianlong Wang,

Libing Chu,

László Wojnárovits

et al.

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 744, P. 140997 - 140997

Published: July 18, 2020

Language: Английский

Citations

710
Assessment of global health risk of antibiotic resistance genes DOI Creative Commons
Zhenyan Zhang, Qi Zhang, Tingzhang Wang

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: March 23, 2022

Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Many can confer resistance, but evaluating relative risks of ARGs is complex. Factors such as abundance, propensity for lateral transmission and ability be expressed pathogens are all important. Here, an analysis at metagenomic level from various habitats (6 types habitats, 4572 samples) detects 2561 that collectively conferred 24 classes antibiotics. We quantitatively evaluate risk humans, defined will confound clinical treatment pathogens, these by integrating accessibility, mobility, pathogenicity availability. Our results demonstrate 23.78% pose a risk, especially those which multidrug resistance. also calculate antibiotic samples four main with machine learning, successfully map global marine over 75% accuracy. novel method surveilling help manage one most important animal health.

Language: Английский

Citations

516
Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment DOI Creative Commons
Sara Rodríguez‐Mozaz, Ivone Vaz‐Moreira,

Saulo Varela Della Giustina

et al.

Environment International, Journal Year: 2020, Volume and Issue: 140, P. 105733 - 105733

Published: April 27, 2020

A comprehensive monitoring of a broad set antibiotics in the final effluent wastewater treatment plants (WWTPs) 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out two consecutive years (2015 2016). This is first study this kind performed at an international level. Within 53 monitored 17 were detected least once WWTPs, i.e.: ciprofloxacin, ofloxacin, enrofloxacin, orbifloxacin, azithromycin, clarithromycin, sulfapyridine, sulfamethoxazole, trimethoprim, nalidixic acid, pipemidic oxolinic cefalexin, clindamycin, metronidazole, ampicillin, tetracycline. The exhibiting highest average concentrations Ireland southern Portugal whereas northern (Norway, Finland Germany) Cyprus exhibited lower total concentration. antibiotic occurrence data effluents used for assessment their impact on aquatic environment. Both, environmental predicted no effect concentration (PNEC-ENVs) PNECs based minimal inhibitory (PNEC-MICs) considered evaluation microbial communities systems evolution resistance, respectively. Based analysis, three compounds, azithromycin cefalexin are proposed as markers pollution, they could occasionally pose risk to Integrated studies like crucial map pollution provide basis designing water quality regular programs.

Language: Английский

Citations

496
Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution DOI
João Botelho, Filipa Grosso,

Luı́sa Peixe

et al.

Drug Resistance Updates, Journal Year: 2019, Volume and Issue: 44, P. 100640 - 100640

Published: May 1, 2019

Language: Английский

Citations

428
Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment DOI Creative Commons

Ya He,

Qingbin Yuan, Jacques Mathieu

et al.

npj Clean Water, Journal Year: 2020, Volume and Issue: 3(1)

Published: Feb. 19, 2020

Abstract Antibiotics are widely used in animal husbandry, and various types of antibiotic resistance genes (ARGs) frequently detected livestock waste around the world. Conventional treatment processes do not completely remove ARGs, resulting their release to soil water environments. Various exposure routes these ARGs humans, including inhalation ingestion antibiotic-resistant bacteria (ARB) that harbor them, may be contributing rise resistant clinical infections increasingly difficult treat with antibiotics. In this review, we assess occurrence variability wastes potential propagation pathways human pathogens. We also review mechanisms environmental factors influence dissemination through pathways, evaluate ARG removal efficiency common management approaches. Challenges research needs for assessing mitigating risk from presented.

Language: Английский

Citations

412
Antibiotic Resistance: One Health One World Outlook DOI Creative Commons
Bilal Aslam, Mohsin Khurshid, Muhammad Arshad

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Nov. 25, 2021

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it now regarded as critical One Health issue. Health's interconnected domains contribute to the emergence, evolution, spread of antibiotic-resistant microorganisms on local global scale, which significant risk factor for health. The persistence resistant microbial species, association determinants at human-animal-environment interface can alter genomes, resulting in superbugs various niches. ABR motivated by well-established link between three domains: human, animal, environmental As result, addressing through approach makes sense. Several countries have implemented national action plans based combat microbes, following Tripartite's Commitment Food Agriculture Organization (FAO)-World Animal (OIE)-World (WHO) guidelines. has been identified concern, efforts are being made mitigate this threat. To summarize, interdisciplinary unified approaches principles required limit dissemination cycle, raise awareness education about antibiotic use, promote policy, advocacy, antimicrobial stewardship.

Language: Английский

Citations

375
Antimicrobial pharmaceuticals in the aquatic environment - occurrence and environmental implications DOI Creative Commons
Ewa Felis, Joanna Kalka, Adam Sochacki

et al.

European Journal of Pharmacology, Journal Year: 2019, Volume and Issue: 866, P. 172813 - 172813

Published: Nov. 18, 2019

The environmental occurrence of antimicrobial pharmaceuticals and antibiotic resistant bacteria genes has become a global phenomenon multifaceted threat. Integrated actions many parties are needed to prevent further aggravation the problem. Well-directed require clear understanding problem, which can be ensured by frequent revaluation existing knowledge disseminating it among relevant audiences. goal this review paper is discuss abundance in aquatic environment context adverse effects caused directly these substances threat associated with antibiotics resistance phenomenon. Several classes (aminoglycosides, β-lactams, glycopeptides, macrolides, fluoroquinolones, sulfonamides trimethoprim, tetracyclines) have been selected illustrate their sources, abundance, degradation routes (transformation products) implications including ecotoxic effect spread within compartments wastewater treatment plants. Wastewater plants indeed main source responsible for prevalence factors environment, since predominantly not designed retain pharmaceuticals. In order limit impurities into better control recommended as well establishment stricter quality standards. Counteracting all above-mentioned threats requires undertake integrated activities based on cooperation professionals scientists from various fields science or industry, such sciences, medicine, veterinary, pharmacology, chemical engineering others.

Language: Английский

Citations

338