Gut microbiota and pancreatic diseases: a microbiome-associated approach in the treatment of chronic pancreatitis DOI Open Access

Н. Б. Губергриц,

T. L. Mozhynа,

N. V. Byelyayeva

et al.

Herald of Pancreatic Club, Journal Year: 2023, Volume and Issue: 60(3), P. 17 - 30

Published: July 11, 2023

Intestinal microbiota is a factor that determines human health, maintains body homeostasis, and influences the development of pancreatic diseases (acute pancreatitis, chronic pancreatitis (CP), cancer). Butyrate, acetate, propionate, key short-chain fatty acids, which are synthesized by probiotic bacteria, have significant effect on functional activity: anti-inflammatory effect, modulation β-cell function, regulation cell mass, strengthening intestinal barrier function. It has been proven course CP associated with dysbiosis, bacterial overgrowth syndrome, decrease in levels Firmicutes Actinobacteria, an increase Proteobacteria phylum, Eubacterium rectale, Coprococcus, Sutterella, ruminantium. Their predominance related to exocrine insufficiency, while Pseudomonas, Fusobacterium, Ruminococcus gnavus more common patients without insufficiency. Activation fibrogenesis Streptomyces, Turicibacter, Methylobacterium, Enterococcus, Candidatus Paenicardiniummore. The mechanism action probiotics improved functioning barrier, decreased BOS inflammatory process, inhibition signaling pathway oncogenesis. microbiome-associated approach treating based additional administration probiotics. multicomponent Laktiale Multi can be drug choice.

Language: Английский

Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study DOI Creative Commons
Kui Wang,

Xianzheng Qin,

Taojing Ran

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 23, 2023

Background A number of recent observational studies have indicated a correlation between the constitution gut microbiota and incidence pancreatitis. Notwithstanding, are unreliable for inferring causality because their susceptibility to confounding, bias, reverse causality, causal relationship specific pancreatitis is still unclear. Therefore, our study aimed investigate four types Methods An investigative undertaking encompassing genome-wide association (GWAS) comprising 18,340 participants was undertaken with aim discerning genetic instrumental variables that exhibit associations microbiota, The aggregated statistical data pertaining acute (AP), alcohol-induced AP (AAP), chronic (CP), CP (ACP) were acquired from FinnGen Consortium. two-sample bidirectional Mendelian randomization (MR) approach utilized. Utilizing Inverse-Variance Weighted (IVW) technique as cornerstone primary analysis. Bonferroni analysis used correct multiple testing, In addition, sensitivity methodologies, MR-Egger intercept test, Cochran’s Q MR polymorphism residual outlier (MR-PRESSO) leave-one-out performed evaluate robustness findings. Results total 28 intestinal microflora ascertained significant diverse outcomes Among them, Class Melainabacteria (OR = 1.801, 95% CI: 1.288–2.519, p 0.008) has strong ACP after Bonferroni-corrected in order assess potential causation effects, we exposure variable scrutinized its impact on outcome variable, this revealed 30 distinct microflora. implementation test lack substantial heterogeneity among various single nucleotide polymorphisms (SNP). Conclusion Our first systematic provides evidence taxa may be causally associated disease. This discovery contribute biomarkers conducive preliminary, non-invasive identification Pancreatitis. Additionally, it could present viable targets therapeutic interventions disease’s treatment.

Language: Английский

Citations

20
The Role of the Gut Microbiome in the Development of Acute Pancreatitis DOI Open Access

Ruilin Zhou,

Qingyang Wu, Zihan Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1159 - 1159

Published: Jan. 18, 2024

With the explosion research on gut microbiome in recent years, much insight has been accumulated comprehending crosstalk between microbiota community and host health. Acute pancreatitis (AP) is one of gastrointestinal diseases associated with significant morbidity subsequent mortality. Studies have elucidated that are engaged pathological process AP. Herein, we summarize major roles development We then portray association dysbiosis severity Finally, illustrate promises challenges arise when seeking to incorporate acute treatment.

Language: Английский

Citations

6
The Mir-146a-Associated Hdac2 Regulation and the Pi3k Signaling Pathway Involved in Chronic Pancreatitis Pain in Vitro DOI
Dingwen Zhong,

Xiang‐Tian Zeng,

Wenhui Chen

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Statin therapy associated Lactobacillus intestinalis attenuates pancreatic fibrosis through remodeling intestinal homeostasis DOI Creative Commons

Yuhang Sui,

Tao Zhang, Suwen Ou

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 15, 2025

Chronic pancreatitis (CP) is characterized by irreversible fibrotic destruction and impaired pancreatic function. CP disrupts lipid metabolism causes the imbalance of gut microbiota which in turn exacerbates fibrosis. Statins alter exert anti-inflammatory effects, but its role has not been fully elucidated. Here, we found that statins-associated higher abundance Lactobacillus intestinalis (L.intestinalis) maintained homeostasis restrained bacteria translocation from to pancreas, eventually aggravated fibrosis through inhibiting CD8+T cells-dependent immunity. Fecal transplantation (FMT) or L.intestinalis administration inhibited infiltration cells macrophages delayed progression. recruitment M1 limited release Ccl2/7 colon, prevented epithelial damage barrier dysfunction blocking Ccl2/7-Ccr1 signaling. Our findings elucidate utilization statin therapy supplementation can be potential approach for therapies CP.

Language: Английский

Citations

0
The miR-146a-associated HDAC2 regulation of PI3K is involved in pancreatitis in vitro DOI
Dingwen Zhong,

Xiang‐Tian Zeng,

Wenhui Chen

et al.

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 42, P. 102057 - 102057

Published: May 20, 2025

Language: Английский

Citations

0
The role of gut microbiome and its metabolites in pancreatitis DOI Creative Commons

Letian Pan,

Nuoming Yin, Mingyu Duan

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Gut microbiome plays a vital role in the intestinal ecosystem and has close association with metabolites. Due to development of metabolomics microbiomics, recent studies have observed that alteration either gut or metabolites may effects on progression pancreatitis. Several new treatments based been studied extensively years. microbes, such as

Language: Английский

Citations

2
Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus DOI Creative Commons
Shengnan Huang, Fangfang Li,

Chen Quan

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 9, 2024

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic β-cells, leading to insulin deficiency and hyperglycemia, its incidence increasing year year. The pathogenesis T1DM complex, mainly including genetic environmental factors. Intestinal flora the largest microbial community in human body plays very important role health disease. In recent years, more studies have shown that intestinal metabolites, as an factor, regulate development through various mechanisms such altering mucosal barrier, influencing secretion immune regulation. transplantation, probiotic supplementation, other approaches modulate appear be potential therapeutic for T1DM. This article reviews dysbiosis T1DM, which affects well discusses treating intervening flora.

Language: Английский

Citations

2
Investigation of the Pharmacological Mechanisms of Shenfu Injection In Acute Pancreatitis Through Network Pharmacology and Experimental Validation DOI Creative Commons
Liming Xu, Tianpeng Wang,

Yingge Xu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e37491 - e37491

Published: Sept. 1, 2024

Language: Английский

Citations

1
Exploring the casual association between gut microbiome, circulating inflammatory cytokines and chronic pancreatitis: A Mendelian randomization analysis DOI Creative Commons

Yang Xiao-qiu,

Hao Xu,

Xiaolu Liang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(18), P. e37959 - e37959

Published: May 3, 2024

It has been established that gut dysbiosis contributed to the pathogenesis of digestive disorders. We aimed explore causal relationships between intestinal microbiota, circulating inflammatory cytokines and chronic pancreatitis (CP). Summary statistics genome-wide association studies (GWAS) microbiome was retrieved from MiBioGen study GWAS data 91 CP were obtained catalog. The 2-sample bidirectional Mendelian randomization (MR) analysis performed CP, in which inverse variance weighted (IVW) method regarded as primary approach. To prove reliability estimations, multiple sensitivity analyses utilized. IVW results revealed genetically predicted 2 genera, including Sellimonas Eubacteriumventriosumgroup, plasm C-C motif chemokine 23 (CCL23) level positively associated with risk, while genus Escherichia Shigella, Eubacteriumruminantiumgroup Prevotella9, plasma Caspase 8, Adenosine Deaminase (ADA), SIR2-like protein (SIRT2) level, demonstrated an ameliorative effect on CP. Leave-one-out confirmed robustness aforementioned effects no significant horizontal pleiotropy or heterogeneity instrumental variables detected. However, found identified genera CP-related cytokines. Besides, reverse MR relationship Taken together, our comprehensive offer evidence favor estimated connections 5 genus-level microbial taxa 4 may help reveal underlying

Language: Английский

Citations

0
Gut microbiota and pancreatic diseases: a microbiome-associated approach in the treatment of chronic pancreatitis DOI Open Access

Н. Б. Губергриц,

T. L. Mozhynа,

N. V. Byelyayeva

et al.

Herald of Pancreatic Club, Journal Year: 2023, Volume and Issue: 60(3), P. 17 - 30

Published: July 11, 2023

Intestinal microbiota is a factor that determines human health, maintains body homeostasis, and influences the development of pancreatic diseases (acute pancreatitis, chronic pancreatitis (CP), cancer). Butyrate, acetate, propionate, key short-chain fatty acids, which are synthesized by probiotic bacteria, have significant effect on functional activity: anti-inflammatory effect, modulation β-cell function, regulation cell mass, strengthening intestinal barrier function. It has been proven course CP associated with dysbiosis, bacterial overgrowth syndrome, decrease in levels Firmicutes Actinobacteria, an increase Proteobacteria phylum, Eubacterium rectale, Coprococcus, Sutterella, ruminantium. Their predominance related to exocrine insufficiency, while Pseudomonas, Fusobacterium, Ruminococcus gnavus more common patients without insufficiency. Activation fibrogenesis Streptomyces, Turicibacter, Methylobacterium, Enterococcus, Candidatus Paenicardiniummore. The mechanism action probiotics improved functioning barrier, decreased BOS inflammatory process, inhibition signaling pathway oncogenesis. microbiome-associated approach treating based additional administration probiotics. multicomponent Laktiale Multi can be drug choice.

Language: Английский

Citations

0