Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102077 - 102077

Published: Sept. 24, 2023

Language: Английский

---

Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 512 - 512

Published: Jan. 24, 2024

Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies reveal a link between accumulation induction. This interconnected relationship presents promising strategy, especially for addressing refractory cancers marked by drug tolerance. Harnessing toxicity iron clinical settings becomes crucial. Simultaneous targeting cuproptosis, exemplified combination sorafenib elesclomol-Cu, represents an intriguing approach. Strategies mitochondria further enhance precision approaches, providing hope improving treatment outcomes drug-resistant cancers. Moreover, chelators copper-lowering agents established therapeutic modalities exhibits synergy that holds promise augmentation anti-tumor efficacy malignancies. review elaborates on complex interplay underlying mechanisms, explores potential druggable targets both research settings.

Language: Английский

---

Ferroptosis inhibitors: past, present and future

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Language: Английский

---

Comprehensive bioinformatics analysis reveals the role of cuproptosis-related gene Ube2d3 in myocardial infarction

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 19, 2024

Background Myocardial infarction (MI) caused by severe coronary artery disease has high incidence and mortality rates, making its prevention treatment a central challenging aspect of clinical work for cardiovascular practitioners. Recently, researchers have turned their attention to novel mechanism cell death Cu 2+ , cuproptosis. Methods This study integrated data from three MI-related bulk datasets downloaded the Gene Expression Omnibus (GEO) database, identified 16 differentially expressed genes (DEGs) related cuproptosis taking intersection 6378 DEGs obtained differential analysis with 49 cuproptosis-related genes. Four hub genes, Dbt, Dlat, Ube2d1 Ube2d3, were screened out through random forest Lasso analysis. In group, showed low expression, while Ube2d3 exhibited expression. Results Focusing on subsequent functional studies, we confirmed expression in MI group qRT-PCR Western Blot detection after successful construction mouse model left anterior descending (LAD) ligation, further clarified correlation development detecting levels proteins. Moreover, vitro experiments, was be highly oxygen-glucose deprivation (OGD)-treated cardiomyocytes AC16. order clarify role knocked down OGD-treated AC16 cells, Ube2d3’s promoting hypoxia damage cells inducing cuproptosis, as evidenced MTT, TUNEL, LDH release Conclusion summary, our findings indicate that regulates affect progression MI.

Language: Английский

---

COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 15, 2024

Abstract Extensive research in countries with high sociodemographic indices (SDIs) to date has shown that coronavirus disease 2019 (COVID-19) may be directly associated more severe outcomes among patients living haematological disorders and malignancies (HDMs). Because individuals moderate immunodeficiency are likely undergo persistent infections, shed virus particles for prolonged periods, lack an inflammatory or abortive phase, this represents overall risk of morbidity mortality from COVID-19. In cases suffering HDMs, further investigation is needed achieve a better understanding triviruses group related variants anemia as well their treatment through vaccines, drugs, other methods. Against background, the present study aimed delineate relationship between HDMs novel COVID-19, acute respiratory syndrome 2 (SARS-CoV-2). Besides, effective options HDM were explored address epidemic its variants. Therefore, learning about how COVID-19 manifests these patients, along exploiting most appropriate treatments, lead development care strategies by clinicians researchers help recover faster.

Language: Английский

---

Limonin (LM) and its derivatives: Unveiling the neuroprotective and anti-inflammatory potential of LM and V-A-4 in the management of Alzheimer's disease and Parkinson's disease

Fitoterapia, Journal Year: 2024, Volume and Issue: 178, P. 106173 - 106173

Published: Aug. 6, 2024

Language: Английский

---

Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Breast cancer is the most commonly diagnosed worldwide. Metal metabolism pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron copper are essential metal ions critical maintaining cellular function. The accumulation of iron triggers distinct death pathways, known as ferroptosis cuproptosis, respectively. Ferroptosis characterized by iron-dependent lipid peroxidation, while cuproptosis involves copper-induced oxidative stress. They increasingly recognized promising targets development anticancer drugs. Recently, compelling evidence demonstrated that interplay between plays a crucial role progression. This review elucidates converging pathways Moreover, we examined value genes associated with clinical diagnosis treatment cancer, mainly outlining potential co-targeting approach. Lastly, delve into current challenges limitations this strategy. In general, offers an overview interaction offering valuable perspectives further research treatment.

Language: Английский

---

UCNPs@PVP‐Hemin‐GOx@CaCO₃ Nanoplatform for Ferroptosis Self‐Amplification Combined with Calcium Overload

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Due to the complexity of tumor microenvironment (TME), current treatments cannot achieve satisfactory results. A nanocomposite material, UCNPs@PVP‐Hemin‐GOx@CaCO 3 (UPHGC NPs) is developed that responds TME and controls release multimodal synergistic therapy in tissues. UPHGC NPs mediate photodynamic (PDT), chemodynamic (CDT), starvation (ST) synergistically, ultimately inducing self‐amplification ferroptosis. The Hemin loaded exhibits peroxidase (POD) activity, which can react with H 2 O produce ·OH (CDT) generate maximum amount ·O − (PDT) under UV excitation from upconversion materials. also consume glutathione (GSH), downregulate 4 (GPX4), combine PDT/CDT induce lipid peroxidation (LPO), leading In addition, Glucose oxidase (GOx) provides sufficient for production, amplifying ROS generation further enhance gluconic acid produced by GOx during ST process synergizes TME's acidic conditions promote Ca 2+ release, intracellular calcium overload, oxidative stress, lead mitochondrial dysfunction, kill cells through damage. Furthermore, externally mineralized carbonate prevent premature drug normal

Language: Английский

---

Effect of Sodium Para-Aminosalicylic Acid on Cuproptosis in PC12 Cells Exposed Manganese, Iron, and Copper

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

---

Effects of Adenosine triphosphate and Coenzyme Q10 on potential hydroxychloroquine-induced retinal damage in rats

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110387 - 110387

Published: April 1, 2025

Language: Английский

---