mTOR Signaling in Growth Control and Disease

Cell, Journal Year: 2012, Volume and Issue: 149(2), P. 274 - 293

Published: April 1, 2012

Language: Английский

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mTOR Signaling in Growth, Metabolism, and Disease

Cell, Journal Year: 2017, Volume and Issue: 168(6), P. 960 - 976

Published: March 1, 2017

Language: Английский

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AKT/PKB Signaling: Navigating the Network

Cell, Journal Year: 2017, Volume and Issue: 169(3), P. 381 - 405

Published: April 1, 2017

Language: Английский

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Cancer Cell, Journal Year: 2012, Volume and Issue: 21(3), P. 297 - 308

Published: March 1, 2012

Language: Английский

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Fundamentals of cancer metabolism

Science Advances, Journal Year: 2016, Volume and Issue: 2(5)

Published: May 6, 2016

Researchers provide a conceptual framework to understand current knowledge of the fundamentals cancer metabolism.

Language: Английский

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The PI3K Pathway in Human Disease

Cell, Journal Year: 2017, Volume and Issue: 170(4), P. 605 - 635

Published: Aug. 1, 2017

Language: Английский

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mTOR at the nexus of nutrition, growth, ageing and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(4), P. 183 - 203

Published: Jan. 14, 2020

Language: Английский

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Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

Cell Metabolism, Journal Year: 2012, Volume and Issue: 15(6), P. 848 - 860

Published: May 17, 2012

Language: Английский

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HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

The Journal of Experimental Medicine, Journal Year: 2011, Volume and Issue: 208(7), P. 1367 - 1376

Published: June 27, 2011

Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over resting state. Although a role for metabolic switch to glycolysis has been suggested support increased anabolic activities and facilitate cell growth proliferation, whether cellular metabolism controls lineage choices remains poorly understood. We report that glycolytic pathway is actively regulated during differentiation inflammatory TH17 Foxp3-expressing regulatory (Treg cells) fate determination. but not Treg cell–inducing conditions resulted in strong up-regulation activity induction enzymes. Blocking inhibited development while promoting generation. Moreover, transcription factor hypoxia-inducible 1α (HIF1α) was selectively expressed its required signaling through mTOR, central regulator metabolism. HIF1α–dependent transcriptional program important mediating activity, thereby contributing between cells. Lack HIF1α diminished enhanced protected mice from autoimmune neuroinflammation. Our studies demonstrate orchestrates checkpoint

Language: Английский

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The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

Nature reviews. Cancer, Journal Year: 2019, Volume and Issue: 20(2), P. 74 - 88

Published: Nov. 4, 2019

Language: Английский

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