Cannabidiol/β-Cyclodextrin Inclusion Complex-Loaded Poly(Vinyl Alcohol) Semi-solid Hydrogels for Potential Use in Wound Management DOI

Pakakrong Sangsanoh,

Sonthaya Chaiarwut, Chasuda Choipang

et al.

Journal of Polymers and the Environment, Journal Year: 2023, Volume and Issue: 31(9), P. 3982 - 3997

Published: April 24, 2023

Language: Английский

Acidic and alkaline deep eutectic solvents (DESs) pretreatment of grapevine: Component analysis, characterization, lignin structural analysis, and antioxidant properties DOI
Yuan Zhu, Tian‐xiao Yang, Benkun Qi

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 236, P. 123977 - 123977

Published: March 10, 2023

Language: Английский

Citations

45
Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs DOI
Isaïe Nyamba,

Charles B Sombié,

Moussa Yabré

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 114513 - 114513

Published: Sept. 1, 2024

Language: Английский

Citations

22
Inclusion complexes of β-cyclodextrin with isomeric ester aroma compounds: Preparation, characterization, mechanism study, and controlled release DOI
Zuobing Xiao,

Peiran Yu,

Pingli Sun

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 121977 - 121977

Published: Feb. 22, 2024

Language: Английский

Citations

18
Development of Stable Nano-Sized Transfersomes as a Rectal Colloid for Enhanced Delivery of Cannabidiol DOI Creative Commons

Thope Moqejwa,

Thashree Marimuthu,

Pierre P. D. Kondiah

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(4), P. 703 - 703

Published: March 25, 2022

Current cannabidiol (CBD) formulations are challenged with unpredictable release and absorption. Rational design of a rectal colloid delivery system can provide practical alternative. In this study the inherent physiochemical properties transferosomes were harnessed for development nano-sized transfersomes to yield more stable release, absorption, bioavailability CBD as colloid. Transfersomes composed soya lecithin, cholesterol, polysorbate 80 synthesized via thin film evaporation characterized size, entrapment efficiency (%), morphology, ex vivo permeation, physicochemical stability. The optimized formulation entrapped up 80.0 ± 0.077% hydrodynamic particle size 130 nm, PDI value 0.285, zeta potential -15.97 mV. morphological investigation SEM TEM revealed that spherical unilamellar vesicles coinciding enhanced permeation across excised rat colorectal membrane. Furthermore, improved stability encapsulated 6 months at room temperature showed significant promise promoted tissue superior afforded tunable kinetics botanical therapeutic poor bioavailability.

Language: Английский

Citations

69
Enhanced Stability and Oral Bioavailability of Cannabidiol in Zein and Whey Protein Composite Nanoparticles by a Modified Anti-Solvent Approach DOI Creative Commons
Ce Wang, Jia Wang, Yonghai Sun

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(3), P. 376 - 376

Published: Jan. 27, 2022

Wide applications of cannabidiol (CBD) in the food and pharmaceutical industries are limited due to its low bioavailability, sensitivity environmental pressures water solubility. Zein nanoparticles were stabilized by whey protein (WP) for delivery using a modified anti-solvent approach. Particle size, surface charge, encapsulation efficiency, re-dispersibility influenced zein WP ratio. Under optimized conditions at 1:4, zein-WP fabricated with CBD (200 μg/mL) further characterized. absorbed on via hydrogen bond, hydrophobic forces, electrostatic attraction. The showed excellent storage stability (4 °C, dark) effectively protected degradation against heat UV light. In vivo pharmacokinetic study demonstrated that displayed 2-times 1.75-fold enhancement maximum concentration (C max) area under curve (AUC) as compared free-form CBD. data indicated feasibility developing based encapsulation, protection,

Language: Английский

Citations

39
Research progress of starch as microencapsulated wall material DOI
Di Zhao, Zhibin Li,

Jiayi Xia

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 318, P. 121118 - 121118

Published: June 12, 2023

Language: Английский

Citations

31
Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration DOI Creative Commons
Grace Tsz Yan Yau, Waiting Tai, Jonathon C. Arnold

et al.

Pharmaceutical Research, Journal Year: 2023, Volume and Issue: 40(5), P. 1087 - 1114

Published: Jan. 12, 2023

Abstract The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. While the mechanism action CBD in these conditions is still under investigation, been shown to affect numerous different drug targets that are involved disorders. Here we review preclinical and clinical evidence on potential therapeutic various Moreover, also examine delivery approaches have applied CBD. Due slow absorption low bioavailability with current oral therapy, more efficient routes administration bypass hepatic metabolism, particularly pulmonary delivery, should be considered. Comparison pharmacokinetic studies highlight advantages intranasal inhalation over other (oral, injection, sublingual, buccal, transdermal) These two being non-invasive able achieve fast increase bioavailability, attracting interest applications, research development expected near future.

Language: Английский

Citations

28
Brain-specific targeted delivery of therapeutic agents using metal–organic framework-based nanomedicine DOI
Zongsu Han, Muzhaozi Yuan, Nguyen Nguyen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215926 - 215926

Published: May 9, 2024

Language: Английский

Citations

10
Harnessing therapeutic deep eutectic solvents in self-emulsifying systems to improve CBD delivery DOI Creative Commons
Gennaro Balenzano, Giuseppe Francesco Racaniello,

Antonio Spennacchio

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124267 - 124267

Published: May 24, 2024

In this study, Cannabidiol crystals (CBD) were used as a BCS class II model drug to generate novel therapeutic deep eutectic solvent (THEDES) with easy preparation using caprylic acid (CA). The hydrogen bonding interaction was confirmed by different techniques such FT-IR and NMR, resulting in hydrophobic system suitable for liquid formulations. CBD-based THEDES, combined specific mixture of surfactants co-surfactants, successfully formed self-emulsifying delivery (SEDDS) that generated uniform nano-sized droplets once dispersed water. Hence, the THEDES showed compatibility approach, offering an alternative method load drugs at their dosage. Physical stability concerns regarding unconventional oily phase addressed through stress tests multiple dynamic light scattering, demonstrating robustness system. addition, formulated SEDDS proved effective protecting CBD from harsh acidic gastric environment up 2 h pH 1.2. Furthermore, vitro studies have safety formulation ability permeate Caco-2 cells when formulated. This investigation highlights potential incorporation lipid-based formulations like SEDDS, expanding avenues innovative oral approaches.

Language: Английский

Citations

7
Development of active packaging films based on liquefied shrimp shell chitin and polyvinyl alcohol containing β-cyclodextrin/cinnamaldehyde inclusion DOI

Zhengjie Qian,

Jie Zhang, Wen‐Rong Xu

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 214, P. 67 - 76

Published: June 11, 2022

Language: Английский

Citations

21