European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 286, P. 117268 - 117268
Published: Jan. 13, 2025
Language: Английский
Molecular Diversity, Journal Year: 2022, Volume and Issue: 26(5), P. 2915 - 2937
Published: Jan. 25, 2022
Language: Английский
Citations
119
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1162 - 1162
Published: Aug. 15, 2023
Fluorine is characterized by high electronegativity and small atomic size, which provide this molecule with the unique property of augmenting potency, selectivity, metabolic stability, pharmacokinetics drugs. (F) substitution has been extensively explored in drug research as a means improving biological activity enhancing chemical or stability. Selective F onto therapeutic diagnostic candidate can enhance several pharmacokinetic physicochemical properties such stability membrane permeation. The increased binding ability fluorinated target proteins also reported some cases. An emerging line on addressed using 18F radiolabel tracer atom extremely sensitive methodology positron emission tomography (PET) imaging. This review aims to report drugs approved US Food Drug Administration (FDA) from 2016 2022. It cites selected examples variety FDA-approved period have heterocyclic cores, including pyrrole, pyrazole, imidazole, triazole, pyridine, pyridone, pyridazine, pyrazine, pyrimidine, triazine, purine, indole, benzimidazole, isoquinoline, quinoline appended either F-18 F-19. Some oligonucleotides were authorized FDA between 2019
Language: Английский
Citations
48
Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(5), P. 565 - 565
Published: May 12, 2023
Antifungal resistance is a growing concern as it poses significant threat to public health. Fungal infections are cause of morbidity and mortality, especially in immunocompromised individuals. The limited number antifungal agents the emergence have led critical need understand mechanisms drug resistance. This review provides an overview importance resistance, classes agents, their mode action. It highlights molecular including alterations modification, activation, availability. In addition, discusses response drugs via regulation multidrug efflux systems drug–target interactions. We emphasize understanding develop effective strategies combat highlight for continued research identify new targets development explore alternative therapeutic options overcome Overall, its will be indispensable field clinical management fungal infections.
Language: Английский
Citations
47
European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 259, P. 115701 - 115701
Published: Aug. 5, 2023
Language: Английский
Citations
46
Reviews and Advances in Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Language: Английский
Citations
3
European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 238, P. 114454 - 114454
Published: May 13, 2022
Language: Английский
Citations
54
The Journal of Physical Chemistry A, Journal Year: 2022, Volume and Issue: 126(17), P. 2716 - 2728
Published: April 20, 2022
We have conducted an extensive search for nitrogen-, oxygen-, and sulfur-bearing heterocycles toward Taurus Molecular Cloud 1 (TMC-1) using the deep, broadband centimeter-wavelength spectral line survey of region from GOTHAM large project on Green Bank Telescope. Despite their ubiquity in terrestrial chemistry, confirmed presence a number cyclic polycyclic hydrocarbon species source, we find no evidence any heterocyclic species. Here, report derived upper limits column densities these molecules obtained by Markov Chain Monte Carlo (MCMC) analysis compare this approach to traditional single-line limit measurements. further hypothesize why are absent our data, how they might form interstellar space, nature observations that would be needed secure detection.
Language: Английский
Citations
42
Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(7), P. 4910 - 4931
Published: March 23, 2023
A unique class of antibacterial azolylpyrimidinediols (APDs) and their analogues were developed. Some synthesized compounds showed excellent bacteriostatic potency; especially, triazolylpyrimidinediol (triazolyl PD) 7a exhibited good anti-Acinetobacter baumannii potential with a low MIC 0.002 mmol/L. Triazolyl PD inconspicuous cytotoxicity hemolytic activity could eradicate the established biofilm, resistance, favorable drug-likeness. Mechanistic explorations revealed that compound without membrane-targeting ability decrease metabolic activity, interact DNA through groove binding action to block replication rather than intercalate into cleave DNA, thus inhibit bacterial growth. Further computations displayed EHOMO large energy gap might help triazolyl biological targets more easily. Moreover, gave appreciable in vivo pharmacokinetic properties pharmacodynamics. These findings as novel structural scaffolds DNA-groove binders imply promise for treatments Acinetobacter infection.
Language: Английский
Citations
31
Heliyon, Journal Year: 2023, Volume and Issue: 9(6), P. e16773 - e16773
Published: June 1, 2023
Pyrimidine derivatives attract researchers due to their versatile scaffold & medicinal significance. associated analogs are majorly contributed the field of chemistry. In this review article, recent new structural design and development active agent studies biological approaches highlighted. addition, potency structure-activity relationship pyrimidines such as antimicrobial, anticancer, anti-inflammatory, analgesic, anti-diabetic, anti-HIV, anthelmintic, CNS depressants, cardiac agents discussed. Finally, article may for novel pyrimidine scaffolds with more less harmful.
Language: Английский
Citations
30
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1307, P. 137965 - 137965
Published: March 5, 2024
Language: Английский
Citations
9