Cheminformatics-Based Design and Synthesis of Hydroxyapatite/Collagen Nanocomposites for Biomedical Applications DOI Open Access
Mohamed Aaddouz, Khalil Azzaoui, Rachid Sabbahi

et al.

Polymers, Journal Year: 2023, Volume and Issue: 16(1), P. 85 - 85

Published: Dec. 27, 2023

This paper presents a novel cheminformatics approach for the design and synthesis of hydroxyapatite/collagen nanocomposites, which have potential biomedical applications in tissue engineering, drug delivery, orthopedic dental implants. The nanocomposites are synthesized by co-precipitation method with different ratios hydroxyapatite collagen. Their mechanical, biological, degradation properties analyzed using various experimental computational techniques. Attenuated total reflection–Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction unveil low crystallinity nanoscale particle size (22.62 nm) composites (14.81 nm). These findings substantiated scanning electron microscopy energy-dispersive confirming Ca/P ratio between 1.65 1.53 attesting to formation non-stoichiometric apatites all samples, further validated molecular simulation. antimicrobial activity is evaluated vitro against several bacterial fungal strains, demonstrating their medical potential. Additionally, silico analyses performed predict absorption, distribution, metabolism, excretion bioavailability collagen samples. study paves way development biomaterials chemoinformatics tools methods, facilitating optimization parameters, as well prediction biological outcomes. Future research directions should encompass investigation vivo biocompatibility bioactivity while exploring functionalities these innovative materials.

Language: Английский

Melamine-Maleic Acid Polyamide Adduct / Polyacrylonitrile Nanofibers as a Novel Adsorbent for Removal of Methyelene Blue Dye from Aqueous Solutions DOI Creative Commons

Ahmed E. Alprol,

M.A. Abu-Saied, Walaa M. Thabet

et al.

Water Air & Soil Pollution, Journal Year: 2024, Volume and Issue: 235(7)

Published: June 12, 2024

Abstract Efficient removal of methylene blue (MB) dye from aqueous solutions is crucial for addressing environmental pollution. This study investigates the potential Melamine-maleic acid polyamide adduct/polyacrylonitrile (ME-MA amide polymer/PAN) nanofibers as a novel adsorbent MB removal. Characterization via scanning electron microscopy (SEM) revealed surface morphology changes, with fiber diameters ranging 1 to 3 μm. Thermal stability analysis demonstrated enhanced ME-MA/PAN compared pure PAN fibers. Fourier transform infrared (FT-IR) confirmed presence hydroxyl, amide, and thiol groups on nanoparticle surface, covalently attached nanofiber surface. Through electrospinning, composites were synthesized, showing promising capabilities Optimal conditions observed at pH 12 ME-MA dose 0.02 g. efficiency increased higher initial concentrations, peaking 30 mg/L, temperatures up 40°C. Adsorption isotherm models indicated Langmuir adsorption capacity (Q m ) 111.10 mg g −1 separation factor (R L 0.297, Freundlich constants (1/n) K F values 0.418 22.9, respectively. Kinetic thermodynamic studies favorable removal, validating polymer/PAN environmentally friendly effective materials eliminating toxic solutions. research highlights in pollution, suggesting their application wastewater treatment sustainable management. Further investigation into regeneration methods scalability recommended practical implementation real-world scenarios.

Language: Английский

Citations

2
Facile Fabrication of Hydroxyapatite and Bentonite Encapsulated Biopolymeric Hybrid Composites for Selective Removal of Methylene Blue DOI

Vellaiyapillai Sathiyajothi,

Natrayasamy Viswanathan,

Mu. Naushad

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(23)

Published: June 18, 2024

Abstract Dyeing industries release their hazardous dyeing effluents into the environment which affects human health and ecosystem. Hence, removal of dye from waste‐water is mandatory one. In this present study, focus on fabrication bio‐clay‐ceramic hybrid composites by dispersing bentonite (BT) clay ceramic hydroxyapatite (HA) alginate (Alg) gelatin (Gel) polymeric matrixes in‐situ method gives BTHAAlg BTHAGel for methylene blue (MB) removal. The various adsorption influencing parameters such as shaking time, adsorbent dosage, pH initial MB concentration were optimized under batch method. highest capacities found to be 43.70 47.50 mg/g respectively with conditions 100 mg/L concentration, 40 min time 0.1 g dosages. studies, high capacity noticed at 11. characterization techniques like FTIR, SEM EDAX analysis performed find physico‐chemical properties composites. equilibrium data towards was well fitted Langmuir isotherm model than D‐R Fruendlich models because higher r low sd values. negative values ▵G o three different temperatures (303, 313 323 K) indicate that spontaneous nature adsorption, while positive ΔH ΔS revealed onto endothermic in more randomness occurred solid/liquid interfaces. kinetic pseudo‐second‐order intra‐particle diffusion models. electrostatic attraction hydrogen bonding plays a dominant role regeneration studies proposed can reusable upto five cycles. developed act best adsorbents

Language: Английский

Citations

2
Effect of citric acid modification on the properties of hydrochar and pyrochar and their adsorption performance toward methylene blue: crucial roles of minerals and oxygen functional groups DOI

Xinru Fan,

Shuo Wang,

Yushan Zhang

et al.

Environmental Monitoring and Assessment, Journal Year: 2024, Volume and Issue: 196(7)

Published: June 26, 2024

Language: Английский

Citations

2
Seawater Intrusion and Nitrate Contamination in the Fum Al Wad Coastal Plain, South Morocco DOI
Abderrazak Errich, Souad El Hajjaji, Mohammed Fekhaoui

et al.

Journal of Earth Science, Journal Year: 2023, Volume and Issue: 34(6), P. 1940 - 1950

Published: Dec. 1, 2023

Language: Английский

Citations

5
Cheminformatics-Based Design and Synthesis of Hydroxyapatite/Collagen Nanocomposites for Biomedical Applications DOI Open Access
Mohamed Aaddouz, Khalil Azzaoui, Rachid Sabbahi

et al.

Polymers, Journal Year: 2023, Volume and Issue: 16(1), P. 85 - 85

Published: Dec. 27, 2023

This paper presents a novel cheminformatics approach for the design and synthesis of hydroxyapatite/collagen nanocomposites, which have potential biomedical applications in tissue engineering, drug delivery, orthopedic dental implants. The nanocomposites are synthesized by co-precipitation method with different ratios hydroxyapatite collagen. Their mechanical, biological, degradation properties analyzed using various experimental computational techniques. Attenuated total reflection–Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction unveil low crystallinity nanoscale particle size (22.62 nm) composites (14.81 nm). These findings substantiated scanning electron microscopy energy-dispersive confirming Ca/P ratio between 1.65 1.53 attesting to formation non-stoichiometric apatites all samples, further validated molecular simulation. antimicrobial activity is evaluated vitro against several bacterial fungal strains, demonstrating their medical potential. Additionally, silico analyses performed predict absorption, distribution, metabolism, excretion bioavailability collagen samples. study paves way development biomaterials chemoinformatics tools methods, facilitating optimization parameters, as well prediction biological outcomes. Future research directions should encompass investigation vivo biocompatibility bioactivity while exploring functionalities these innovative materials.

Language: Английский

Citations

5