Spiderweb‐Shaped Iron‐Coordinated Polymeric Network as the Novel Coating on Microneedles for Transdermal Drug Delivery Against Infectious Wounds DOI

Xinwei Fu,

Tao Zhang,

Chuanlan Xia

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 12, 2024

Abstract Coated microneedles (CMNs) are a minimally invasive platform for immediate‐release transdermal drug delivery. However, the practical applications of CMNs have been significantly hindered by challenges associated with complex formulations, single function, and limited loading capacity. This study has developed spiderweb‐shaped iron‐coordinated polymeric nanowire network (Fe‐IDA NWs). The resulting Fe‐IDA NWs endowed certain viscosity due to synergy multiple supramolecular interactions. allows them replace traditional thickeners as microneedle coatings. NWs‐coated MNs) display rapid disintegration in skin model, which also enables swift diffusion their payloads into deeper layers. Additionally, MNs exhibit desirable enzymatic activity potential antibacterial ability. Thus, can enhance therapeutic efficacy against wound infection through synergistic effects, avoid overly complicated formulation release nontherapeutic molecules conventional CMNs. As proof‐of‐concept, loaded chlorin e6 showed chemodynamic‐photodynamic effect methicillin‐resistant Staphylococcus aureus‐infected model mice. Collectively, this work significant implications future CMNs‐based delivery systems expands application fields metal coordination polymer (MCP) materials.

Language: Английский

A molecular sensor for selective recognition of Fe3+ by a functional seven-nuclear Zn(II) cluster compound formed from a quinoline-modified half-salamo-type Precursor DOI
Lele Liu, Haiwei Zhang, Jixiang Ren

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 331, P. 125762 - 125762

Published: Jan. 23, 2025

Language: Английский

Citations

1
A novel dual-functional half salamo-based fluorescent turn-on sensor for selectively recognition and differentiation of Zn2+ and Al3+ ions DOI
Li-Li Man,

Tong-Lin Wang,

Ke Liu

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137586 - 137586

Published: Jan. 16, 2024

Language: Английский

Citations

7
Catecholase and phenoxazinone synthase activities of two structurally characterized mononuclear complexes [Cu(L)(NCS)(ClO4)] and [Zn(L)(NCS)2] [L = N,N-diethyl-2-((phenyl(pyridin-2-yl)methylene)-amino)ethan-1-amine] DOI

Indrani Ray Chowdhury,

Arnab Chatterjee, Abhinandan Mahanta

et al.

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 566, P. 122006 - 122006

Published: March 7, 2024

Language: Английский

Citations

7
Comprehensive insights of a Salamo-like Oligo(N,O-donor) ligand and its self-assembled di-nuclear Mn(III) and tetra-nuclear Cd(II) complexes DOI

Lumei Pu,

Shizhen Li,

Yi-Bin Yan

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138264 - 138264

Published: April 5, 2024

Language: Английский

Citations

5
Spiderweb‐Shaped Iron‐Coordinated Polymeric Network as the Novel Coating on Microneedles for Transdermal Drug Delivery Against Infectious Wounds DOI

Xinwei Fu,

Tao Zhang,

Chuanlan Xia

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 12, 2024

Abstract Coated microneedles (CMNs) are a minimally invasive platform for immediate‐release transdermal drug delivery. However, the practical applications of CMNs have been significantly hindered by challenges associated with complex formulations, single function, and limited loading capacity. This study has developed spiderweb‐shaped iron‐coordinated polymeric nanowire network (Fe‐IDA NWs). The resulting Fe‐IDA NWs endowed certain viscosity due to synergy multiple supramolecular interactions. allows them replace traditional thickeners as microneedle coatings. NWs‐coated MNs) display rapid disintegration in skin model, which also enables swift diffusion their payloads into deeper layers. Additionally, MNs exhibit desirable enzymatic activity potential antibacterial ability. Thus, can enhance therapeutic efficacy against wound infection through synergistic effects, avoid overly complicated formulation release nontherapeutic molecules conventional CMNs. As proof‐of‐concept, loaded chlorin e6 showed chemodynamic‐photodynamic effect methicillin‐resistant Staphylococcus aureus‐infected model mice. Collectively, this work significant implications future CMNs‐based delivery systems expands application fields metal coordination polymer (MCP) materials.

Language: Английский

Citations

5