Facile synthesis and spectral analysis of the bioactive spiroborate compounds as a novel therapeutic agent for computational insights, biological evaluation, and applications

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123510 - 123510

Published: Jan. 1, 2025

Language: Английский

---

Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150464 - 150464

Published: July 27, 2024

Language: Английский

---

Discovery of Hydrazine Clubbed Thiazoles as Potential Antidiabetic Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Feb. 1, 2025

ABSTRACT In this study, hydrazine clubbed thiazole derivatives ( 3a – 3j ) were obtained by Hantzsch synthesis and characterized MS, 1 H NMR, 13 C NMR. The inhibitory potentials of the against diabetes‐related enzymes such as aldose reductase (AR), α‐glycosidase (α‐GLY), α‐amylase (α‐AMY) experimentally determined, results supported molecular docking. showed that displayed varied degree potential activity, with K I values covering following ranges: 5.47 ± 0.53 to 23.89 1.46 nM for AR 1.76 0.01 24.81 0.15 μM α‐GLY, IC 50 4.94–28.17 α‐AMY, compared standard epalrestat acarbose : 34.53 2.52 23.53 2.72 respectively). selective activity these on antidiabetic may be important treatment diabetes lead development alternative new compounds purpose.

Language: Английский

---

Targeted Breast Cancer Combat: The Pioneering Role of Hesperidin-Infused pH and Thermosensitive Nanoparticles

Russian Journal of General Chemistry, Journal Year: 2025, Volume and Issue: 95(3), P. 562 - 571

Published: March 1, 2025

Language: Английский

---

Green Extraction Strategies and Bioactivity of Rheum cordatum Losinsk: Antioxidant, Antimicrobial, and Molecular Docking Insights

Plants, Journal Year: 2025, Volume and Issue: 14(7), P. 1071 - 1071

Published: April 1, 2025

This study aimed to compare the efficiency of different green extraction methods for obtaining bioactive compounds from roots Rheum cordatum Losinsk and evaluate their antioxidant antimicrobial properties. The presence some important phytochemicals in extracts obtained using ultrasound-assisted (UAE), subcritical ethanol (Sbc-EtOH), supercritical CO2 (ScCO2) was determined by LC-MS/MS, properties were examined against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli. goal determine optimal conditions that maximize yield while preserving biological Different pressures (100 bar 400 bar) tested UAE extraction, solvents times Sbc-EtOH ScCO2 extraction. Most 53 phenolic have been extracted method, either exclusively or highest amounts. It has observed more higher amounts at lower pressure. activity exhibited extracts. Additionally, ScCO2-100 extract 100 showed strong activity, with a minimum inhibitory concentration (MIC) ranging 31.25 250 μg/mL. Gallic acid, epicatechin gallate, epigallocatechin catechin found molecular docking studies 1QWZ, 2ANQ, 3H77, 6QXS proteins revealed scores -6.127, -9.479, -5.836, -7.067 kcal/mol, respectively.

Language: Английский

---

Salicylaldehyde-Derived Hydrazones: Synthesis, Characterization, Antibacterial Activity, Antioxidant and Anti-Inflammatory Effects on LPS-Induced RAW264.7 Macrophage Cells, Drug-Likeness Properties, and Molecular Docking Analysis

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151872 - 151872

Published: April 1, 2025

Language: Английский

---

Development of DFO chelator-attached adsorptive membranes for selective removal of Fe3+ ions to obtain clean drinking water

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142458 - 142458

Published: April 1, 2025

Language: Английский

---

Enhanced Anti‐Cancer Efficacy of Hesperidin through Smart Polymeric Nanoparticles Targeting Prostate Cancer

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(36)

Published: Sept. 1, 2024

Abstract The rapid progress of various nanotechnology tools is currently being utilized in the management several fatal illnesses, including cancer. Nanopolymers that encapsulate anti‐cancer medication present a highly encouraging substitute to traditional therapies, primarily because their specific targeting and accurate functionality, making them suitable for variety uses. Poly(2‐hydroxyethyl methacrylate) (pHEMA) non‐toxic polymer derived from monomer HEMA, which known its toxicity. It can be combined with other polymers associated minimal immune response. objective current investigation produce smart polymeric nanoparticles are responsive changes pH temperature, capable encapsulating hesperidin. These hesperidin‐loaded poly(2‐Hydroxyethyl methacrylate‐N‐isopropylacrylamide‐Vinyl imidazole) nanoparticles, referred as HesSNPs, aim enhance bioavailability hesperidin augment therapeutic effectiveness combating prostate N ‐isopropylacrylamide Vinyl imidazole were employed monomers sensitive temperature pH, respectively. synthesized underwent characterization through dynamic light scattering (DLS) analyses, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) analyze particle size charge, surface morphology, functional group determinations, HesSNPs decreased cell viability DU‐145 cells. Flow cytometry analysis revealed apoptosis main mechanism underlying death after treatment.

Language: Английский

---

Naringenin-loaded pHEMA cryogel membrane: preparation, characterization, antibacterial activity and in silico studies

Chemical Papers, Journal Year: 2024, Volume and Issue: 79(1), P. 211 - 220

Published: Nov. 11, 2024

Language: Английский

---

Simultaneous quantitative screening of 53 phytochemicals from Rheum tataricum L. roots: a comparative study of supercritical CO2, subcritical ethanol, and ultrasound-assisted extraction for enhanced antioxidant, antibacterial activities, and molecular docking study

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

In this study,

Language: Английский

---