Food Control, Journal Year: 2022, Volume and Issue: 138, P. 108986 - 108986
Published: April 1, 2022
Language: Английский
Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9
Published: April 14, 2022
Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the treatment of different types cancers management chronic inflammatory diseases. However, its use is associated with hepatotoxicity. Vitamin C (VC) curcumin (CUR) exhibit anti-inflammatory antioxidant effects. Thus, we aimed to investigate potential hepatoprotective effects VC CUR pretreatment alone combination against MTX-induced Albino mice were randomly divided into 7 groups: control group, which received only normal saline; MTX group; pretreated (100 or 200 mg/kg/day orally) for 10 days; (10 20 orally); mg/kg) mg/kg). was administered (20 mg/kg, intraperitoneally) all groups on tenth day induce Forty eight hours after administration, anesthetized. Blood samples collected, liver removed biochemical analysis, a part tissue preserved formalin histopathological analysis. The results indicated that induced more significant decrease serum levels alanine transaminase, aspartate alkaline phosphatase, lactic dehydrogenase increase level superoxide dismutase glutathione; furthermore, it malondialdehyde improvement changes tissues, confirming therapy injury. To conclude, hepatotoxicity mediated by induction oxidative stress as evident increased lipid peroxidation reduction enzyme activity. Pretreatment VC, their reduces combined effect provided synergistic surpasses but seems be similar mg/kg/day. Therefore, large dose could effective In this regard, further studies are warranted confirm
Language: Английский
Citations
51
Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 282, P. 119127 - 119127
Published: Jan. 12, 2022
Language: Английский
Citations
44
Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 68, P. 103092 - 103092
Published: Jan. 5, 2022
Language: Английский
Citations
42
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 112992 - 112992
Published: April 19, 2022
Owing to its intricate pathophysiology, impaired wound healing is one of the substantial challenges in treatment burn wounds (BWs). Despite variety conventional therapies available, morbidities associated with BWs have not subsided. Therefore, aim present study was design an advanced nanotechnology-composited therapy for effectual management BWs. Hyaluronic acid (HA)-functionalized curcumin (CUR) and quercetin (QUE) co-loaded nanoparticle (HA-CUR-QUE-CSNPs) were fabricated, optimized, characterized evaluated successful co-encapsulation drugs, morphology, stability, drug release, cell proliferation, penetration across skin, localization epidermis dermis, vivo efficacy. Fabricated HA-functionalized CSNPs exhibited ultra-small size (177 ± 11 nm), good zeta potential (+37.0 3.2 mV), high encapsulation efficiency (EE) (QUE ∼84% CUR ∼64%) loading capacity (LC) ∼38% ∼43%), spherical shape uniformly rough surface. showed a triphasic release pattern Fickian diffusion kinetics, time-mannered progression MC3T3-E1 cells improved (2414 µg/cm2) QUE (1984 through stratum corneum, drugs dermis. A superior efficacy (98% closure rate at day 28) marked histological signs minimal infiltration inflammatory cells, re-epithelization, ECM formation, fibroblast site, granulation tissue angiogenesis, collagen deposition also evidenced. This concludes that HA-functionalization polymeric NPs could be promising approach maximize skin efficiency, tissues, regeneration healing.
Language: Английский
Citations
42
Food Control, Journal Year: 2022, Volume and Issue: 138, P. 108986 - 108986
Published: April 1, 2022
Language: Английский
Citations
40