Materials Advances, Journal Year: 2022, Volume and Issue: 3(21), P. 7687 - 7708
Published: Jan. 1, 2022
As one of the current research hotspots, drug release nanoplatforms have great potential in treatment autoimmune inflammatory diseases.
Language: Английский
Nutrients, Journal Year: 2022, Volume and Issue: 14(11), P. 2208 - 2208
Published: May 26, 2022
Sweet tea (Lithocarpus litseifolius [Hance] Chun) is a new resource for food raw materials, with plenty of health functions. This study aimed to investigate the preventive effect and potential mechanism sweet extract (STE) against ulcerative colitis (UC). Briefly, BABL/c mice were treated STE (100 400 mg/kg) 2 weeks prevent 3% dextran sulfate sodium (DSS)-induced UC. It was found that supplementation significantly prevented DSS-induced UC symptoms; suppressed levels pro-inflammatory mediators, such as myeloperoxidase tumor necrosis factor-α; increased anti-inflammatory cytokines; up-regulated expression tight junction proteins (Zonula occludens-1 Occludin). also altered gut microbiota profile by increasing Bacteroidetes, Lactobacillus, Akkermansia, Lachnospiraceae_NK4A136_group, Alistipes inhibiting Firmicutes, Proteobacteria, Helicobacter, accompanied significant increase in content butyric acid. Moreover, G-protein-coupled receptor (GPR) 43 GPR109A inhibited histone deacetylase 3 (HDAC3) nuclear factor-κB p65 (NF-κB p65) colon. In conclusion, this indicated has good on regulating activate butyrate-GPR-mediated signaling simultaneously inhibit HDAC3/NF-κB inflammatory signaling.
Language: Английский
Citations
33
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(8), P. 3367 - 3382
Published: April 2, 2022
With the development of synthesis technology, modified messenger RNA (mRNA) has emerged as a novel category therapeutic agents for broad diseases. However, effective intracellular delivery mRNA remains challenging, especially its sensitivity to enzymatic degradation. Here, we propose polyphenol-assisted handy strategy efficient in vivo IL-10 mRNA. binds polyphenol ellagic acid through supramolecular binding yield negatively charged core, followed by complexing with linear polyetherimide and coating bilirubin-modified hyaluronic obtain layer-by-layer nanostructure. The nanostructure specifically up-regulated level IL-10, effectively inhibited expression inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, exerted potent efficacy dextran sulfate sodium salt-induced acute chronic murine models colitis. designed system without systemic toxicity potential facilitate promising platform ulcerative colitis treatment.
Language: Английский
Citations
29
Materials & Design, Journal Year: 2024, Volume and Issue: 238, P. 112645 - 112645
Published: Jan. 6, 2024
Ulcerative colitis (UC) is an idiopathic, chronic, and progressive inflammatory set of conditions that affects the colonic mucosa. Natural Polyphenols are well documented for their excellent antioxidant properties have obvious advantages in strategy anti-oxidation treatment UC. However, poor water solubility, low bioavailability, unstable nature hindered clinical application. Therefore, we efficiently encapsulated bioactive polyphenol epigallocatechin gallate (EGCG) with poly(N-vinylpyrrolidone) (PVP) via reliable intermolecular hydrogen-bonded interactions, conjugated polysaccharide chondroitin sulfate (CS) gastrointestinal stability CD44 active targeting capability onto surfaces to achieve targeted delivery (EPC). The obtained EPC system showed average diameter 54 nm, monodisperse size distribution negatively charged surface. In vitro studies demonstrated reactive oxygen species (ROS)-scavenging anti-inflammatory ability system. After oral administration, localized inflamed colon effectively alleviated symptoms dextran sodium salt (DSS)-induced UC mice. Specifically, down-regulated expression cytokines, up-regulated tight junction-associated proteins restore intestinal barrier, modulated gut microbiota. This drug a simple self-assembling process may pave new polyphenol-based therapy
Language: Английский
Citations
7
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(25), P. 31950 - 31965
Published: June 11, 2024
Ulcerative colitis (UC) is a recurrent chronic mucosal inflammation disease whose most significant pathological characteristics are intestinal and damaged barrier induced by reactive oxygen/nitrogen species, abnormal immune microenvironment, microecological imbalance. Oral probiotics living therapy for diseases, but their clinical application hindered poor bacterial biological activity insufficient retention. Here, we developed targeted oral formulation, functionalized probiotic Lf@MPB, with Lactobacillus fermentum (Lf) as the core modified melanin nanoparticles (MNPs) on its surface through click reaction of tricarboxyphenylboronic acid synergistic UC. In vitro experiments showed that Lf@MPB not only possessed strong free radical scavenging ability, reduced cellular mitochondrial polarization, inhibited apoptosis also significantly enhanced viability Lf in simulated gastrointestinal fluid. Fluorescence imaging vivo revealed high accumulation at site dextran sulfate sodium-induced UC mice. Moreover, results demonstrated effectively alleviated oxidative stress inflammatory response restored barrier. addition, 16S rRNA gene sequencing verified could increase abundance diversity microbial communities optimize composition to inhibit progression This work combines effective antioxidant anti-inflammatory strategies administration provide promising alternative treatment.
Language: Английский
Citations
7
European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113338 - 113338
Published: July 26, 2024
Language: Английский
Citations
7
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1172 - 1172
Published: Sept. 5, 2024
Drug delivery systems (DDSs) represent an emerging focus for many researchers and they are becoming progressively crucial in the development of new treatments. Great attention is given to all challenges that a drug has overcome during its journey across barriers tissues pharmacokinetics modulations needed order reach targeting sites. The goal these pathways drugs controlled way, optimizing their bioavailability minimizing side effects. Recent innovations DDSs include various nanotechnology-based approaches, such as nanoparticles, nanofibers micelles, which provide effective targeted sustained release therapeutics. In this context, protein-based gaining significant pharmaceutical field due potential revolutionize efficient delivery. As natural biomolecules, proteins offer distinct advantages, including safety, biocompatibility biodegradability, making them fascinating alternative synthetic polymers. Moreover, carriers, those derived from gelatin, albumin, collagen, gliadin silk proteins, demonstrate exceptional stability under physiological conditions, allow release, enhancing therapeutic efficacy. This review provides comprehensive overview current trends, challenges, future perspectives delivery, focusing on types adopted techniques being developed enhance functionality terms affinity capabilities, underscoring significantly impact modern
Language: Английский
Citations
7
Biomaterials Science, Journal Year: 2021, Volume and Issue: 9(17), P. 5868 - 5883
Published: Jan. 1, 2021
Ulcerative colitis (UC) is an idiopathic inflammatory condition of colorectal regions.
Language: Английский
Citations
34
Gels, Journal Year: 2022, Volume and Issue: 8(3), P. 155 - 155
Published: March 3, 2022
In the current research work, pH-sensitive hydrogels were prepared via a free radical polymerization technique for targeted delivery of 5-aminosalicylic acid to colon. Various proportions chitosan, β-Cyclodextrin, and acrylic cross-linked by ethylene glycol dimethacrylate. Ammonium persulfate was employed as an initiator. The development new polymeric network successful encapsulation drug confirmed Fourier transform infrared spectroscopy. Thermogravimetric analysis indicated high thermal stability hydrogel compared pure chitosan β-Cyclodextrin. A rough hard surface revealed scanning electron microscopy. Similarly, crystallinity fabricated evaluated using powder X-ray diffraction. swelling release studies performed in both acidic basic medium (pH 1.2 7.4, respectively) at 37 °C. High observed pH 7.4 1.2. increased incorporation led increase porosity, swelling, loading, release, gel fraction hydrogel, whereas decrease sol observed. Thus, we can conclude from results that developed could be promising carrier systems.
Language: Английский
Citations
24
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(22)
Published: Sept. 13, 2022
Abstract Ulcerative colitis (UC) is a prevalent idiopathic inflammatory disease which causes such complications as intestinal perforation, obstruction, and bleeding, thus deleteriously impacting people's normal work quality of life. Hence, accurate diagnosis UC crucial in terms planning optimal treatment plan. Herein, pH/reactive oxygen species (ROS) dual‐responsive nanosystem (BM@EP) developed for UC's detection therapy. BM@EP composed chromophore‐drug dyad the enteric coating. The (BOD‐XT‐DHM) synthesized by linking chromophore (BOD‐XT‐BOH) flavonoid drug (dihydromyricetin DHM) through boronate ester bond. coating includes Eudragit S100 poly(lactic‐ co ‐glycolic acid) (PLGA), former commonly employed pH‐dependent polymer excipient so to attain colon‐targeted delivery, latter has been widely used an controlled‐extended release. After oral administration, delivers into colon releases molecules being triggered alkaline pH t colon, thereafter upon stimulated overexpressed H 2 O inflamed bond broken down correspondingly DHM released therapy, simultaneously near‐infrared second window (NIR‐II) fluorescence optoacoustic imaging recovery evaluation.
Language: Английский
Citations
23
ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(8), P. 4781 - 4793
Published: July 27, 2023
Ulcerative colitis (UC) is a chronic inflammation-related disease that severely affects the colon and rectum regions. A variety of therapy regimens are used for treatment UC. Clinically, therapeutic enema choice UC patients. Irrespective on-site administration, major limitation enemas dispossession medicine followed by low drug availability action. In our present work, we have developed an enzyme-responsive injectable hydrogel (ER-hydrogel) to overcome limitations enema. The hydrogels possess two advantages, which being exploited delivery in UC: prolonged retention enzyme responsiveness. former one prominent advantages compared free latter controls release or provides on-demand. ER-hydrogel was formulated heat-cool method purposes, corticosteroid drug, budesonide (Bud), encapsulated into evaluated its various physicochemical potentials dextran sodium sulfate (DSS)-induced vitro ex vivo adhesion studies confirm mucoadhesive nature ER-hydrogel, upsurge Bud from Bud-loaded upon addition esterase confirms enzyme-mediated ER-hydrogel. Moreover, exhibited promising results alleviating activity index UC, restored length colon, main hallmark terms health tissue, colonic tissue damage, as seen H&E-stained, AB-NR-stained, HID-AB-stained sections. Finally, also markedly subsided IL-1β, TNF-α, MPO, nitrite levels serum tissues. Thus, fabricated possesses appreciable translational potential due ability significantly ameliorate inflammatory changes naive water-based acute experimental mice.
Language: Английский
Citations
16