Journal of Hematology & Oncology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Nov. 30, 2023
Inflammation
is
a
fundamental
defensive
response
to
harmful
stimuli,
but
the
overactivation
of
inflammatory
responses
associated
with
most
human
diseases.
Reactive
oxygen
species
(ROS)
are
class
chemicals
that
generated
after
incomplete
reduction
molecular
oxygen.
At
moderate
levels,
ROS
function
as
critical
signaling
molecules
in
modulation
various
physiological
functions,
including
responses.
However,
at
excessive
exert
toxic
effects
and
directly
oxidize
biological
macromolecules,
such
proteins,
nucleic
acids
lipids,
further
exacerbating
development
causing
Therefore,
designing
manufacturing
biomaterials
scavenge
has
emerged
an
important
approach
for
restoring
homeostasis,
limiting
protecting
host
against
damage.
This
review
systematically
outlines
dynamic
balance
production
clearance
under
conditions.
We
focus
on
mechanisms
by
which
regulate
cell
proteins
how
these
affect
inflammation.
Furthermore,
we
discuss
use
potential
currently
available-biomaterials
ROS,
agents
were
engineered
reduce
levels
blocking
generation,
chemically
reacting
or
catalytically
accelerating
clearance,
treatment
Finally,
evaluate
challenges
prospects
controlled
material
design
scavenging
biomaterials.
Materials Today Bio,
Journal Year:
2021,
Volume and Issue:
11, P. 100124 - 100124
Published: June 1, 2021
Reactive
oxygen
species
(ROS)
mediate
multiple
physiological
functions;
however,
the
over-accumulation
of
ROS
causes
premature
aging
and/or
death
and
is
associated
with
various
inflammatory
conditions.
Nevertheless,
there
are
limited
clinical
treatment
options
that
currently
available.
The
good
news
owing
to
considerable
advances
in
nanoscience,
types
nanomaterials
unique
ROS-scavenging
abilities
influence
temporospatial
dynamic
behaviors
biological
systems
have
been
developed.
This
has
led
emergence
next-generation
nanomaterial-controlled
strategies
aimed
at
ameliorating
ROS-related
Accordingly,
herein
we
reviewed
recent
progress
research
on
nanotherapy
based
scavenging.
underlying
mechanisms
employed
emphasized.
Furthermore,
important
issues
developing
cross-disciplinary
nanomedicine-based
for
ROS-based
conditions
discussed.
Our
review
this
increasing
interdisciplinary
field
will
benefit
ongoing
studies
applications
nanomedicine
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(11), P. 2288 - 2288
Published: Oct. 25, 2022
Wound
healing
is
an
intricate
process
of
tissue
repair
or
remodeling
that
occurs
in
response
to
injury.
Plants
and
plant-derived
bioactive
constituents
are
well
explored
the
treatment
various
types
wounds.
Curcumin
a
natural
polyphenolic
substance
has
been
used
since
ancient
times
Ayurveda
for
its
properties,
as
it
reduces
inflammation
acts
on
several
stages.
Several
research
studies
curcumin
delivery
at
wound
site
reported
effectiveness
eradicating
reactive
oxygen
species
ability
enhance
deposition
collagen,
granulation
formation,
finally,
expedite
contraction.
widely
investigated
potential
but
lower
solubility
rapid
metabolism,
addition
shorter
plasma
half-life,
have
limited
applications
healing.
As
nanotechnology
proven
be
effective
technique
accelerate
by
stimulating
appropriate
mobility
through
phases,
curcumin-loaded
nanocarriers
targeted
sites.
This
review
highlights
nanoformulations,
such
liposomes,
nanoparticles,
nano-emulsions,
etc.
paper
emphasizes
numerous
biomedical
which
collectively
prepare
base
antibiofilm
wound-healing
action.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(11), P. 3566 - 3566
Published: June 1, 2022
Wound
healing
is
a
complicated
process,
and
the
effective
management
of
wounds
major
challenge.
Natural
herbal
remedies
have
now
become
fundamental
for
skin
disorders
treatment
infections
due
to
side
effects
modern
medicine
lower
price
products.
The
aim
present
study
summarize
most
recent
in
vitro,
vivo,
clinical
studies
on
preparations,
their
phytochemical
constituents,
new
formulations
wound
management.
Research
reveals
that
several
medicaments
marked
activity
this
ascribed
flavonoids,
alkaloids,
saponins,
phenolic
compounds.
These
phytochemicals
can
act
at
different
stages
process
by
means
various
mechanisms,
including
anti-inflammatory,
antimicrobial,
antioxidant,
collagen
synthesis
stimulating,
cell
proliferation,
angiogenic
effects.
application
natural
compounds
using
nanotechnology
systems
may
provide
significant
improvement
efficacy
treatments.
Increasing
use
these
therapies
would
require
safety
assessment
trials.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(2), P. 351 - 351
Published: Jan. 17, 2022
The
search
for
higher-quality
nanomaterials
medicinal
applications
continues.
There
are
similarities
between
electrospun
fibers
and
natural
tissues.
This
property
has
enabled
to
make
significant
progress
in
medical
applications.
However,
limited
tissue
scaffolding
When
nanoparticles
nanofibers
combined,
the
composite
material
can
perform
more
functions,
such
as
photothermal,
magnetic
response,
biosensing,
antibacterial,
drug
delivery
biosensing.
To
prepare
nanofiber
nanoparticle
hybrids
(NNHs),
there
two
primary
ways.
electrospinning
technology
was
used
produce
NNHs
a
single
step.
An
alternate
way
is
use
self-assembly
technique
create
fibers.
paper
describes
creation
of
from
routinely
biocompatible
polymer
composites.
Single-step
procedures
methodologies
discuss
preparation
NNHs.
It
combines
recent
research
discoveries
focus
on
application
release,
engineering
last
years.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(10)
Published: Jan. 1, 2023
Abstract
Diabetic
foot
ulcer
(DFU)
is
one
of
the
most
common
complications
diabetes,
bringing
physical
and
mental
challenges
for
patients
due
to
lack
efficient
curative
therapy.
Despite
considerable
advances
in
pharmacological
surgical
approaches,
clinical
trials
DFU
remain
disappointing
local
overactive
excessive
inflammation.
Immunomodulatory
hydrogels
has
significant
advantages
overcome
challenge
DFUs
Here,
recent
fabrication
regenerative
utilization
functional
altering
immune
microenvironment
are
comprehensively
reviewed.
The
pathological
features
healing
processes
DFUs,
followed
by
summarizing
physicochemical
properties
essential
design
immunomodulation
briefly
introduced.
Then,
potential
immuno‐therapeutic
modalities
emerging
trends
used
treat
via
multitherapeutic
approaches
enhanced
efficacy
safety
discussed.
Taken
together,
linking
structural
their
functions
therapy
with
a
particular
focus
on
immunomodulatory
stimuli,
this
review
can
promote
further
designing
advanced
resulting
improved
diabetic
wound
repair
through
translation
into
setting
near
future.
