ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(12), P. 14054 - 14062
Published: March 15, 2024
Nanofibers
have
high
potential
through
their
porosity,
small
pore
sizes,
lightweight
materials,
and
ability
to
mimic
the
extracellular
matrix
structure
for
use
in
manufacture
of
wound
dressings
treatment.
In
this
study,
poly(lactic-co-glycolic
acid)
(PLGA)
nanofibers
were
produced
by
electrospinning.
Propolis
was
loaded
into
PLGA
dropping
method.
The
average
diameters
effects
propolis
loading
on
morphology
37.5,
50,
100%
propolis-loaded
(PLGA-P37.5,
PLGA-P50,
PLGA-P100)
evaluated
scanning
electron
microscopy
(SEM).
successful
confirmed
with
Fourier
transform
infrared
spectroscopy
(FTIR)
analysis.
vitro
release
examined
at
physiological
pH.
antioxidant
activity
studied
2,2-diphenyl-1-picrylhydrazyl
(DPPH).
Antimicrobial
activities
against
Escherichia
coli,
Staphylococcus
aureus
Candida
albicans
strains
determined
disk
diffusion
Consequently,
PLGA-P50
PLGA-P100
showed
antimicrobial
S.
C.
albicans.
Cell
viability
tested
3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium
bromide
(MTT)
assay,
found
be
biocompatible
human
fibroblast
cells.
scratch
supported
closure
cell
migration
proliferation.
Thus,
properties
first
time
literature.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(18), P. 10975 - 10975
Published: Sept. 19, 2022
Chitosan,
a
naturally
abundant
cationic
polymer,
is
chemically
composed
of
cellulose-based
biopolymers
derived
by
deacetylating
chitin.
It
offers
several
attractive
characteristics
such
as
renewability,
hydrophilicity,
biodegradability,
biocompatibility,
non-toxicity,
and
broad
spectrum
antimicrobial
activity
towards
gram-positive
gram-negative
bacteria
well
fungi,
etc.,
because
which
it
receiving
immense
attention
biopolymer
for
plethora
applications
including
drug
delivery,
protective
coating
materials,
food
packaging
films,
wastewater
treatment,
so
on.
Additionally,
its
structure
carries
reactive
functional
groups
that
enable
reactions
electrochemical
interactions
at
the
biomolecular
level
improves
chitosan's
physicochemical
properties
functionality.
This
review
article
highlights
extensive
research
about
properties,
extraction
techniques,
recent
developments
chitosan-based
composites
drug,
gene,
protein,
vaccine
delivery
applications.
Its
versatile
in
tissue
engineering
wound
healing
are
also
discussed.
Finally,
challenges
future
perspectives
chitosan
biomedical
elucidated.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(1), P. 184 - 184
Published: Jan. 16, 2023
Herbal
medicine
has
a
long
history
of
medical
efficacy
with
low
toxicity,
side
effects
and
good
biocompatibility.
However,
the
bioavailability
extract
raw
herbs
bioactive
compounds
is
poor
because
their
water
solubility.
In
order
to
overcome
solubility
issues,
electrospinning
technology
can
offer
delivery
alternative
resolve
them.
The
electrospun
fibers
have
advantages
high
specific
surface
area,
porosity,
excellent
mechanical
strength
flexible
structures.
At
same
time,
various
natural
synthetic
polymer-bound
mimic
extracellular
matrix
applications
in
different
fields.
this
paper,
development
polymers
used
for
incorporating
herbal
into
nanofibers
are
reviewed.
Finally,
recent
progress
these
biomedical
(drug
delivery,
wound
dressing,
tissue
engineering)
food
fields
along
future
prospects
discussed.
Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
ABSTRACT
Wound
healing,
especially
for
severe
injuries,
require
dressings
that
absorb
exudate,
prevent
infection,
and
support
healing
without
causing
trauma
upon
removal.
Traditional
single‐layered
often
fail
to
balance
moisture
retention
protection,
hindering
optimal
healing.
To
address
this,
a
bilayered
scaffold
was
fabricated
comprising
an
electrospun
hydrophilic
sublayer
of
Pullulan/Polyvinyl
alcohol
(PVA)/Gum
arabic
blend
loaded
with
Gentamicin
solvent‐casted
hydrophobic
top
layer
Polylactic
acid
(PLA).
The
designed
direct
wound
contact
ease
dressing
removal,
while
the
enhance
mechanical
properties,
loss,
protect
against
external
environment.
exhibited
antibacterial
activity
Staphylococcus
aureus
Escherichia
coli
,
controlled
release
93.09%
±
2.63%
within
48
h,
best
described
by
zero‐order
model
(
R
2
=
0.9850).
It
demonstrated
swelling
index
611.85%
15.05%,
indicating
its
excellent
exudate
absorbing
capacity.
water
vapor
transmission
rate
(WVTR)
porosity
were
94.20
14.50
g/m
/day
70.56%
0.58%,
respectively,
both
falling
permissible
range
Additionally,
in
vitro
biocompatibility
assays
conducted
on
human
dermal
fibroblast
(HDF)
cells
confirmed
noncytotoxicity
applicability
applications.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(12), P. 1727 - 1727
Published: Nov. 22, 2022
Chronic
diabetic
wounds
are
one
of
the
main
complications
diabetes,
manifested
by
persistent
inflammation,
decreased
epithelialization
motility,
and
impaired
wound
healing.
This
will
not
only
lead
to
repeated
hospitalization
patients,
but
also
bear
expensive
costs.
In
severe
cases,
it
can
amputation,
sepsis
or
death.
Electrospun
nanofibers
membranes
have
characteristics
high
porosity,
specific
surface
area,
easy
functionalization
structure,
so
they
be
used
as
a
safe
effective
platform
in
treatment
great
application
potential.
article
briefly
reviewed
pathogenesis
chronic
types
dressings
commonly
used,
then
development
electrospinning
technology
recent
years
advantages
electrospun
wounds.
Finally,
reports
different
nanofiber
on
summarized,
method
using
multi-drug
combination
therapy
is
emphasized,
which
provides
new
ideas
for
Macromolecular Bioscience,
Journal Year:
2022,
Volume and Issue:
22(7)
Published: April 14, 2022
A
wound
can
be
surgical
cuts
from
an
operation
or
due
to
accident
and
trauma.
The
infected
wound,
as
a
result
of
bacteria
growth
within
the
damaged
skin,
interrupts
natural
healing
process
significantly
impacts
quality
life.
Wound
dressing
is
important
segment
skincare
industry
with
its
economic
burden
estimated
at
$
20.4
billion
(in
2021)
in
global
market.
results
recent
clinical
trials
suggest
that
use
modern
dressings
easiest,
most
accessible,
cost-effective
way
treat
chronic
wounds
and,
hence,
holds
significant
promise.
With
sheer
number
market,
selection
correct
confusing
for
clinicians
healthcare
workers.
aim
this
research
review
widely
used
types
antibacterial
dressings,
well
emerging
products,
their
efficiency
mode
action.
In
review,
introducing
antibiotics
nanoparticles
two
clinically
categories
agents
focused.
perspectives
challenges
paving
future
field
are
also
discussed.
Small,
Journal Year:
2023,
Volume and Issue:
19(48)
Published: Aug. 11, 2023
An
asymmetric
wound
dressing
acts
as
a
skin-like
structure
serves
protective
barrier
between
and
its
surroundings.
It
allows
for
the
absorption
of
tissue
fluids
release
active
substances
at
site,
thus
speeding
up
healing
process.
However,
production
such
dressings
requires
acquisition
specialized
tools,
expensive
polymers,
solvents
that
contain
harmful
byproducts.
In
this
study,
an
bacterial
cellulose
(ABC)
using
starch
porogen
has
been
developed.
By
incorporating
silver-metal
organic
frameworks
(Ag-MOF)
curcumin
into
ABC
membrane,
gains
antioxidant,
reactive
oxygen
species
(ROS)
scavenging,
anti-bacterial
activities.
Compared
to
BC-based
dressings,
promotes
efficient
dissolution
controlled
silver
ions.
full-thickness
skin
defect
model,
not
only
inhibits
growth
bacteria
on
infected
wounds
but
also
regulates
reduce
inflammation
promote
epithelium,
blood
vessels,
collagen.
Consequently,
provides
superior
treatment
compared
dressing.
