Piezoelectric Effect Polyvinylidene Fluoride (PVDF): From Energy Harvester to Smart Skin and Electronic Textiles

Advanced Materials Technologies, Journal Year: 2023, Volume and Issue: 8(14)

Published: May 5, 2023

Abstract With the great demand for flexible self‐powered sensors and nanogenerators, polyvinylidene fluoride (PVDF) is widely investigated outstanding piezoelectric dielectric constant. In pursuit increasing β content, electrospinning exhibited to be an effective method without external high voltage pooling or mechanical stretching thus considered a cost‐effective simple method, because molecular dipoles in PVDF can aligned during process of with field stretching. The methods improving characteristics are briefly introduced this review, fibers including uniaxial fibers, highly core–shell Janus revealed, research on theoretical modeling carried out efficiency design nanogenerator. Last, studies prospective applications based electrospun its copolymer PVDF‐TrFE, from smart skin, energy harvesters electronic textiles, being conducted.

Language: Английский

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Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing

Materials, Journal Year: 2023, Volume and Issue: 16(15), P. 5459 - 5459

Published: Aug. 3, 2023

The treatment of skin wounds caused by trauma and pathophysiological disorders has been a growing healthcare challenge, posing great economic burden worldwide. use appropriate wound dressings can help to facilitate the repair healing rate defective skin. Natural polymer biomaterials such as collagen hyaluronic acid with excellent biocompatibility have shown promote restoration However, low mechanical properties fast degradation limited their applications. Skin based on biodegradable biocompatible synthetic polymers not only overcome shortcomings natural but also possess favorable for applications in wounds. Herein, we listed several used dressing materials, PVA, PCL, PLA, PLGA, PU, PEO/PEG, focusing composition, fabrication techniques, functions promoting healing. Additionally, future development prospects polymer-based are put forward. Our review aims provide new insights further using polymers.

Language: Английский

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Recent Progress of Electrospun Herbal Medicine Nanofibers

Biomolecules, Journal Year: 2023, Volume and Issue: 13(1), P. 184 - 184

Published: Jan. 16, 2023

Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability extract raw herbs bioactive compounds is poor because their water solubility. In order to overcome solubility issues, electrospinning technology can offer delivery alternative resolve them. The electrospun fibers have advantages high specific surface area, porosity, excellent mechanical strength flexible structures. At same time, various natural synthetic polymer-bound mimic extracellular matrix applications in different fields. this paper, development polymers used for incorporating herbal into nanofibers are reviewed. Finally, recent progress these biomedical (drug delivery, wound dressing, tissue engineering) food fields along future prospects discussed.

Language: Английский

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Electrospun Polycaprolactone/Chitosan Nanofibers Containing Cordia myxa Fruit Extract as Potential Biocompatible Antibacterial Wound Dressings

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2501 - 2501

Published: March 9, 2023

The goal of the current work was to create an antibacterial agent by using polycaprolactone/chitosan (PCL/CH) nanofibers loaded with Cordia myxa fruit extract (CMFE) as antimicrobial for wound dressing. Several characteristics, including morphological, physicomechanical, and mechanical surface wettability, activity, cell viability, in vitro drug release, were investigated. inclusion CMFE PCL/CH led increased swelling capability maximum weight loss. SEM images PCL/CH/CMFE mat showed a uniform topology free beads average fiber diameter 195.378 nm. Excellent activity shown towards Escherichia coli (31.34 ± 0.42 mm), Salmonella enterica (30.27 0.57 Staphylococcus aureus (21.31 0.17 Bacillus subtilis (27.53 1.53 Pseudomonas aeruginosa (22.17 0.12 mm) based on inhibition zone assay. sample containing 5 wt% had lower water contact angle (47 3.7°), high porosity, compared neat mat. release 5% CMFE-loaded proven be anomalous non-Fickian diffusion Korsmeyer-Peppas model. Compared pure PCL membrane, PCL-CH/CMFE membrane exhibited suitable cytocompatibility L929 cells. In conclusion, fabricated nanofibrous films demonstrated bioavailability, properties that can used dressings.

Language: Английский

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Enhancing wound healing and minimizing scarring: A comprehensive review of nanofiber technology in wound dressings

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 147, P. 101350 - 101350

Published: Aug. 6, 2024

Wound healing is a complex biological process that, when impaired, can lead to the formation of scars. Electrospun nanofibrous wound dressings have emerged as promising option for promoting scar-free healing. This paper explores role physical, compositional, and chemical cues, each contributing remarkable potential these dressings. The physical properties dressings, such porosity mechanical characteristics, guide cellular behaviors promote vascularization, fostering conducive environment reduced scarring. Furthermore, integration natural polymers that mimic skin's extracellular matrix, known compositional adds another layer complexity As therapeutic agents demonstrated their combat chronic scenarios leading scar formation. However, achieving desired effect hinges on nature controlled release. Therefore, also delves into various loading techniques tailoring release profiles bioactive agents. Although electrospun are viable commercial product remains elusive. gap be attributed lack comprehensive in vivo studies, particularly animal models human

Language: Английский

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Nanocellulose derived from agricultural biowaste by-products–Sustainable synthesis, biocompatibility, biomedical applications, and future perspectives: A review

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 8, P. 100529 - 100529

Published: June 20, 2024

Cellulose, a natural linear biopolymer composed of hierarchically arranged cellulose nanofibrils, presents compelling avenue for sustainable nanocellulose synthesis from agricultural by-products. This innovative approach both mitigates organic waste and landfill disposal unlocks the latent potential nanocellulose, transforming residue into valuable resources. paradigm shift towards sustainability resonates across diverse industrial sectors, particularly in biomedical research development. In recent years, remarkable attributes including its biocompatibility, low cytotoxicity, exceptional water-holding capacity cell immobilization, have propelled adoption various medical applications. From drug delivery systems to wound healing, tissue engineering, antimicrobial treatments, has emerged as versatile biomaterial. Moreover, strategic integration composites structural functionalization enable customizing properties specific functions, further expanding utility. comprehensive review explores prominent types nanocellulose—including nanocrystals, microbial or bacterial cellulose—elucidating their underscores principles underpinning utilization by exploring sources derived biowaste processes production. As crucial component wide array materials, drives innovation propels advancement biomedicine toward sustainability.

Language: Английский

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Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles

Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 257 - 270

Published: April 14, 2023

Neutrophil extracellular traps (NETs) have been considered a significant unfavorable factor for wound healing in diabetes, but the mechanisms remain unclear. The therapeutic application of small vesicles (sEVs) derived from mesenchymal stem cells (MSCs) has received considerable attention their properties. Hypoxic preconditioning is reported to enhance potential MSC-derived sEVs regenerative medicine. Therefore, aim this study illustrate detailed mechanism NETs impairment diabetic and develop promising NET-targeting treatment based on hypoxic pretreated (Hypo-sEVs). Excessive were found wounds high glucose (HG)-induced neutrophils. Further research showed that concentration impaired function fibroblasts through activating endoplasmic reticulum (ER) stress. Hypo-sEVs efficiently promoted reduced excessive NET formation by transferring miR-17-5p. Bioinformatic analysis RNA interference experiment revealed miR-17-5p obstructed targeting TLR4/ROS/MAPK pathway. Additionally, overexpression decreased overcame NET-induced fibroblasts, similar effects Hypo-sEVs. Overall, we identify previously unrecognized NET-related provide strategy treatment.

Language: Английский

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Asymmetric wettability fibrous membranes: Preparation and biologic applications

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 269, P. 111095 - 111095

Published: Nov. 18, 2023

Language: Английский

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Biopolymers in diabetic wound care management: A potential substitute to traditional dressings

European Polymer Journal, Journal Year: 2023, Volume and Issue: 189, P. 111979 - 111979

Published: March 7, 2023

The poor healing of diabetic wound affects large proportion human beings by high mortality rate and associated expenditures. Such chronic wounds mainly become problematic due to unavailability suitable environmental conditions which lead cell migration, proliferation uncontrolled inflammation. An ideal dressing should prohibit dryness allow a environment at the injury surface. However, present therapeutics lacks potential overcome these problems resulting in their limited clinical success. There is shift research domain from synthetic natural polymeric materials issues with traditional dressings. Many biological organisms' extracted polymers are useful for ease availability various active substances. naturally occurring polysaccharides proteins find several attractive applications biomedical field.These substances not only non-toxic but also possess characteristics. In this work, proteins-based biopolymers utilized recent years as material discussed. This review will surely provide guidance researchers using effective economical material.

Language: Английский

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Nanofibrous Scaffolds for Diabetic Wound Healing

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 986 - 986

Published: March 19, 2023

Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining concentration within normal ranges, but this can quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care prevent such as sepsis, amputation, and deformities, which these patients. Although several conventional dressings, hydrogels, gauze, films, foams, employed treatment chronic wounds, nanofibrous scaffolds gained attention researchers because their flexibility, ability load a variety bioactive compounds single entities or combinations, large surface area volume ratio, provides biomimetic environment for cell proliferation relative dressings. Here, we present current trends on versatility novel platforms incorporation agents suitable enhancement healing.

Language: Английский

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