Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 95 - 115
Published: April 7, 2025
Language: Английский
Bone Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Jan. 23, 2024
Abstract Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture, which increases patient susceptibility to fragile fractures. The intricate mechanisms governing homeostasis are substantially impacted extracellular vesicles (EVs), play crucial roles in both pathological physiological contexts. EVs derived from various sources exert distinct effects on osteoporosis. Specifically, released osteoblasts, endothelial cells, myocytes, mesenchymal stem cells contribute formation due their unique cargo proteins, miRNAs, cytokines. Conversely, secreted osteoclasts immune promote resorption inhibit formation. Furthermore, use as therapeutic modalities or biomaterials for diagnosing managing osteoporosis promising. Here, we review current understanding impact homeostasis, including classification biogenesis regulatory present an overview latest research progress treating using EVs. Finally, discuss challenges prospects translational
Language: Английский
Citations
30
Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)
Published: March 3, 2025
Abstract Bone tissue relies on the intricate interplay between blood vessels and nerve fibers, both are essential for many physiological pathological processes of skeletal system. Blood provide necessary oxygen nutrients to bone tissues, remove metabolic waste. Concomitantly, fibers precede during growth, promote vascularization, influence cells by secreting neurotransmitters stimulate osteogenesis. Despite critical roles components, current biomaterials generally focus enhancing intraosseous vessel repair, while often neglecting contribution nerves. Understanding distribution main functions in is crucial developing effective engineering. This review first explores anatomy highlighting their vital embryonic development, metabolism, repair. It covers innovative regeneration strategies directed at accelerating intrabony neurovascular system over past 10 years. The issues covered included material properties (stiffness, surface topography, pore structures, conductivity, piezoelectricity) acellular biological factors [neurotrophins, peptides, ribonucleic acids (RNAs), inorganic ions, exosomes]. Major challenges encountered neurovascularized materials clinical translation have also been highlighted. Furthermore, discusses future research directions potential developments aimed producing repair that more accurately mimic natural healing tissue. will serve as a valuable reference researchers clinicians novel into practice. By bridging gap experimental practical application, these advancements transform treatment defects significantly improve quality life patients with bone-related conditions.
Language: Английский
Citations
2
Bone Research, Journal Year: 2023, Volume and Issue: 11(1)
Published: Dec. 20, 2023
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral endings release neurogenic factors and sense signals, mediate bone metabolism pain. In recent years, tissue engineering has increasingly focused on the effects of nervous system regeneration. Simultaneous regeneration nerves through use materials or by enhancement endogenous repair signals been proven to promote functional Additionally, emerging information mechanisms interoception central regulation homeostasis provide an opportunity for advancing biomaterials. However, comprehensive reviews this topic are lacking. Therefore, review provides overview relationship between regeneration, focusing applications. We discuss novel regulatory explore innovative approaches based nerve-bone interactions Finally, challenges future prospects field briefly discussed.
Language: Английский
Citations
42
Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 377 - 393
Published: April 21, 2023
Crosstalk between nerves and bone is essential for repair, which Schwann cells (SCs) are crucial in the regulation of microenvironment. Considering that exosomes critical paracrine mediators intercellular communication exert important effects tissue aim this study to confirm function molecular mechanisms cell-derived (SC-exos) on regeneration propose engineered constructs simulate SC-mediated nerve–bone crosstalk. SCs promoted proliferation differentiation marrow mesenchymal stem (BMSCs) through exosomes. Subsequent mechanism studies demonstrated SC-exos BMSC osteogenesis by regulating TGF-β signaling pathway via let-7c-5p. Interestingly, migration tube formation performance endothelial progenitor cells. Furthermore, [email protected]/S were developed bioprinting technology simulated crosstalk improved microenvironment releasing SC-exos, exerting regulatory effect promote innervation, vascularization, thus effectively improving repair a cranial defect model. This demonstrates role underlying provides new strategy repair.
Language: Английский
Citations
39
Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(4), P. 1867 - 1903
Published: Feb. 29, 2024
Over the past decades, emerging evidence in literature has demonstrated that innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The nerve-bone axis sparked extensive preclinical clinical investigations aimed at elucidating contribution crosstalks to skeleton metabolism, homeostasis, injury repair through perspective neurobiology. To date, peripheral nerves have been widely reported mediate growth development fracture healing via secretion neurotransmitters, neuropeptides, axon guidance factors, neurotrophins. Relevant studies further identified several critical neural pathways stimulate profound alterations cell biology, revealing complex interplay between nerve systems. In addition, inspired by crosstalk, novel drug delivery systems bioactive materials developed emulate facilitate process natural neuromodulation, eventually boosting osteogenesis ideal tissue regeneration. Overall, this work aims review research findings contribute deepening current understanding axis, bringing forth some schemas can be translated into scenario highlight roles neuromodulation system.
Language: Английский
Citations
15
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Abstract Electrospinning is a significant manufacturing strategy to create micro/nanofiber platforms that can be considered biomedical scaffold for tissue engineering repair and regeneration. In recent years researchers have continuously broadened the equipment design materials development of electrospinning nanofiber (ENPs), which evolved from single‐needle multi‐needle creating 3D ENPs, diversify their application including drugs/cell/growth factors release, anti‐bacterial anti‐inflammatory, hemostasis, wound healing, Herein, multifunctional ENPs with bioactive polymer fabricated via in terms novel material design, construction various structures, requirements different regeneration are reviewed. Furthermore, this review delves into advancements facilitated by highlighting effectiveness versatility across types such as bone, cartilage, tendons, cardiac tissue, nerves. The discussion comprehensively addresses ongoing challenges selection, biodegradation mechanisms, bioactivation strategies, techniques specific applications. Moreover, outlines potential future research avenues aimed at enhancing ENPs‐based approaches engineering. This in‐depth analysis aims provide nuanced insights technical recommendations propel field forward
Language: Английский
Citations
11
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Aptamers represent a distinct category of short nucleotide sequences or peptide molecules characterized by their ability to bind specific targets with high precision. These are predominantly synthesized through SELEX (Systematic Evolution Ligands Exponential Enrichment) technology. Recent findings indicate that aptamers may have significant applications in regenerative medicine, particularly the domain tissue repair. In comparison other bioactive agents, exhibit superior specificity and affinity, more readily accessible, can be chemically modified, thereby presenting promising avenue for functionalization engineering materials repair applications. This review delineates properties examines methodologies advancements related aptamer-functionalized hydrogels, nanoparticles, electrospun materials. It categorizes four primary functions repair, namely regeneration, delivery systems, anti-inflammatory actions, pro-coagulation effects. Furthermore, explores utilization bone, nerve, vascular tissues, highlighting mechanisms which facilitate growth role transporting substances promote Lastly, addresses future prospects challenges associated application offering novel insights directions further research this domain.
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
The skeleton is highly innervated by numerous nerve fibers. These fibers, in addition to transmitting information within the bone and mediating sensations, play a crucial role regulating tissue formation regeneration. Traditional engineering (BTE) often fails achieve satisfactory outcomes when dealing with large-scale defects, which frequently related lack of effective reconstruction neurovascular network. In recent years, increasing research has revealed critical nerves metabolism. Nerve fibers regulate cells through neurotransmitters, neuropeptides, peripheral glial cells. Furthermore, also coordinate vascular immune systems jointly construct microenvironment favorable for As signaling driver formation, neuroregulation spans entire process physiological activities from embryonic postmaturity remodeling repair. However, there currently comprehensive summaries these regulatory mechanisms. Therefore, this review sketches out function during Then, we elaborate on mechanisms coupling neuromodulation immunity. Finally, discuss several novel strategies neuro-bone (NBTE) based bone, focusing coordinated regeneration tissue.
Language: Английский
Citations
1
Small, Journal Year: 2023, Volume and Issue: 19(37)
Published: April 28, 2023
Abstract The effective regeneration of weight‐bearing bone defects and critical‐sized cartilage remains a significant clinical challenge. Traditional treatments such as autologous allograft grafting have not been successful in achieving the desired outcomes, necessitating need for innovative therapeutic approaches. Nucleic acids attracted attention due to their ability be designed form discrete structures programmed perform specific functions at nanoscale. advantages nucleic acid nanotechnology offer numerous opportunities in‐cell vivo applications, hold great promise advancing field biomaterials. In this review, current abilities applied are summarized insights into challenges future directions development technology provided.
Language: Английский
Citations
21
Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100605 - 100605
Published: March 11, 2023
Cancer stem cells (CSCs) are believed to be the main cause of chemotherapy resistance and tumor relapse. Various therapeutic strategies eliminate CSCs have been developed recently. Aptamers, also called "chemical antibodies", can specifically bind with their molecular targets through special tertiary structures. The advantages aptamers, such as lower immunogenicity smaller size, make them superior conventional antibodies. Therefore, aptamers used widely targeting ligands for CSC-targeted in different types. To date, various cargoes conjugated kill CSCs, drugs, small interfering RNAs, microRNAs. Aptamer-based targeted therapies made great progress recent years, especially development multifunctional aptamer-based strategies. Besides, cell-systematic evolution by exponential enrichment has applied screen new that might a higher binding ability CSCs. In this review, we focus on advances introduce some modalities aptamer-drug conjugates against Some considerations limitations discussed.
Language: Английский
Citations
19