BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 5, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1313 - 1313
Published: Feb. 4, 2025
Colorectal cancer (CRC) is the third most common and associated with a poor prognosis. The mutation profile related involved pathways of CRC have been, in broad terms, analyzed. main current therapeutic approaches been comprehensively reviewed here, future possible therapeu-tic options technologies perspectively presented. complex scenario represented by multiple-level resistance mechanism epidermal growth factor receptor (EGFR) pathway, including mutations KRAS, NRAS, BRAF V600E, discussed. Examples engineered from literature along drug combination tested clinical trials are encouraging results observed latter (the BEACON trial), totally free chemotherapy, prompted authors to imagine nanotechnology-assisted approach for bypassing mechanisms, hopefully allowing, principle, complete biological remission.
Language: Английский
Citations
2
Small Science, Journal Year: 2024, Volume and Issue: 4(8)
Published: May 28, 2024
The authors, actively engaged in the development of mesoporous silica‐based solutions, initially for modified drug release, later smart administration conventional chemotherapeutic cytotoxic drugs, present evolution concept targeted therapy across different disciplines. They also discuss diverse therapeutic needs and related challenges (adverse effects) that have unfolded over last 30 years. Nanomedicine potentialities, mainly against cancers, emerged globally during intense research activity few decades, are critically discussed. authors glimpse growing potential immune‐based including those assisted by nanotechnology, as well molecular therapies (MTT) on which they focus. advantages offered therapies, despite limits monotargeted suggest engineering multi‐targeted therapies. solutions such ligand‐specific internalization pH‐sensitive release extensively tested recently presented open literature, still remain available instruments. According to MTT can offer shining perspectives near future will depend a thorough comprehension nanostructures synthesis tumor physiology. This article gives an interdisciplinary point view tailored non‐specialist readers imagining possible scenarios field.
Language: Английский
Citations
9
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 660, P. 124314 - 124314
Published: June 9, 2024
Mesoporous silica nanoparticles (MSNs) endowed with polymer coatings present a versatile platform, offering notable advantages such as targeted, pH-controlled, and stimuli-responsive drug delivery. Surface functionalization, particularly through amine carboxyl modification, enhances their suitability for polymerization, thereby augmenting versatility applicability. This review delves into the diverse therapeutic realms benefiting from polymer-coated MSNs, including photodynamic therapy (PDT), photothermal (PTT), chemotherapy, RNA delivery, wound healing, tissue engineering, food packaging, neurodegenerative disorder treatment. The multifaceted potential of MSNs underscores significance focal point future research endeavors clinical applications. A comprehensive analysis various polymers biopolymers, polydopamine, chitosan, polyethylene glycol, polycaprolactone, alginate, gelatin, albumin, others, is conducted to elucidate advantages, benefits, utilization across biomedical disciplines. Furthermore, this extends its scope beyond polymerization applications encompass topics surface chemical modification recent patents in MSN domain, toxicity associated polymerization. Additionally, brief discourse on green also included review, highlighting fostering sustainable future.
Language: Английский
Citations
8
Biosensors, Journal Year: 2023, Volume and Issue: 13(6), P. 628 - 628
Published: June 6, 2023
Convenient and rapid detection of alpha fetoprotein (AFP) is vital for early diagnosis hepatocellular carcinoma. In this work, low-cost (0.22 USD single sensor) stable (during 6 days) electrochemical aptasensor was developed highly sensitive direct AFP in human serum with the assist vertically-ordered mesoporous silica films (VMSF). VMSF has silanol groups on surface regularly ordered nanopores, which could provide binding sites further functionalization recognition aptamer also confer sensor excellent anti-biofouling capacity. The sensing mechanism relies target AFP-controlled diffusion Fe(CN)63-/4- redox probe through nanochannels VMSF. resulting reduced responses are related to concentration, allowing linear determination a wide dynamic range low limit detection. Accuracy potential were demonstrated by standard addition method.
Language: Английский
Citations
22
Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5105 - 5105
Published: June 29, 2023
Due to the ever-growing global population, it is necessary develop highly effective processes that minimize impact of human activities and consumption on environment. The levels organic inorganic contaminants have rapidly increased in recent years, posing a threat ecosystems. Removing these toxic pollutants from environment challenging task requires physical, chemical, biological methods. An solution involves use novel engineered materials, such as silica-based nanostructured which exhibit high removal capacity for various pollutants. starting materials are also thermally mechanically stable, allowing easy design development at nanoscale through versatile functionalization procedures, enabling their pollutant capture. However, improvements concerning mechanical properties or applicability repeated cycles may be required refine structural features. This review focuses hybrid/composite polymer-silica materials. state art nanomaterial synthesis, different techniques functionalization, polymer grafting described. Furthermore, explores application polymer-modified capture heavy metals, dyes, hydrocarbons petroleum derivatives, drugs, other compounds. paper concludes by offering recommendations future research aimed advancing efficiency uptake.
Language: Английский
Citations
20
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(17), P. 2476 - 2476
Published: Sept. 1, 2023
Breast cancer represents the most common type and one of major leading causes death in female worldwide population. Overexpression HER2, a transmembrane glycoprotein related to epidermal growth factor receptor, results biologically clinically aggressive breast subtype. It is also primary driver for tumor detection progression and, addition being an important prognostic women diagnosed with cancer, HER2 widely known therapeutic target drug development. The aim this review provide updated overview main approaches diagnosis treatment HER2-positive proposed literature over past decade. We focused on different targeting strategies involving antibodies peptides that have been explored their relative outcomes current limitations need be improved. encompasses discussion targeted acting as probes molecular imaging. By using types HER2-targeting strategies, nanotechnology promises overcome some clinical challenges by developing novel HER2-guided nanosystems suitable powerful tools imaging, targeting, therapy.
Language: Английский
Citations
20
Antibiotics, Journal Year: 2024, Volume and Issue: 13(2), P. 173 - 173
Published: Feb. 9, 2024
Nanotechnology has emerged as a cornerstone in contemporary research, marked by the advent of advanced technologies aimed at nanoengineering materials with diverse applications, particularly to address challenges human health. Among these challenges, antimicrobial resistance (AMR) risen significant and pressing threat public health, creating obstacles preventing treating persistent diseases. Despite efforts recent decades combat AMR, global trends indicate an ongoing concerning increase AMR. The primary contributors escalation AMR are misuse overuse various agents healthcare settings. This led severe consequences not only terms compromised treatment outcomes but also substantial financial burdens. economic impact is reflected skyrocketing costs attributed heightened hospital admissions increased drug usage. To this critical issue, it imperative implement effective strategies for therapies. comprehensive review will explore latest scientific breakthroughs within metal–organic frameworks use mesoporous metallic oxide derivates agents. We their biomedical applications shedding light on promising avenues combating Finally, we conclude current state research offer perspectives future development nanomaterials battle against
Language: Английский
Citations
7
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 94, P. 105504 - 105504
Published: Feb. 24, 2024
Language: Английский
Citations
5
European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 12, P. 100206 - 100206
Published: Aug. 23, 2024
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 575 - 575
Published: April 24, 2024
The study aimed to enhance the solubility of poorly water-soluble drug, fenofibrate, by loading it onto mesoporous silica, forming amorphous solid dispersions. Solid dispersions with 30% fenofibrate were prepared using solvent evaporation method three solvents (ethyl acetate, acetone, and isopropanol) at different temperatures (40 °C, boiling point temperature). Various characteristics, including solid-state properties, particle morphology, drug release, evaluated methods compared a pure physical mixture silica. Results revealed that higher facilitated complete amorphization rapid choice having lesser impact. optimal conditions for preparation identified as ethyl acetate temperature. amounts (20%, 25%, 35%) under these conditions. All formulations fully amorphous, their dissolution profiles comparable formulation fenofibrate. Stability assessments after 8 weeks 40 °C 75% relative humidity indicated physically stable. Interestingly, some showed improved initial tests. In conclusion, silica-based effectively demonstrated good stability if appropriate
Language: Английский
Citations
4