Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 469 - 541
Published: Jan. 1, 2023
Language: Английский
Small Methods, Journal Year: 2023, Volume and Issue: 8(1)
Published: Oct. 26, 2023
Abstract Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and biological factors, manifesting as loss of motor sensory functions. Inhibition expansion even reversal in the acute damage stage SCI are important strategies for treating this disease. Hydrogels nanoparticle (NP)‐based drugs most effective, widely studied, clinically valuable therapeutic field repair regeneration. 3D flow structures that fill pathological gaps provide microenvironment similar to spinal extracellular matrix nerve cell NP‐based can easily penetrate blood‐spinal barrier, target lesions, noninvasive. NPs drug carriers be loaded with various factors slow release lesions. They help function more efficiently exerting anti‐inflammatory, antioxidant, regeneration effects promote recovery neurological function. In review, use hydrogels role both discussed multimodal strategic reference after SCI.
Language: Английский
Citations
24
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Sept. 2, 2023
Abstract Background Basic fibroblast growth factor (bFGF) is one of the critical components accelerating angiogenesis and tissue regeneration by promoting migration dermal fibroblasts endothelial cells associated with matrix formation remodeling in wound healing process. However, clinical applications bFGF are substantially limited its unstable nature due to rapid decomposition under physiological microenvironment. Results In this study, we present bFGF-loaded human serum albumin nanoparticles (HSA-bFGF NPs) as a means enhanced stability sustained release platform during regeneration. Spherical shape HSA-bFGF NPs uniform size distribution (polydispersity index < 0.2) obtained via simple desolvation crosslinking The securely load intact soluble proteins, thereby significantly enhancing proliferation activity fibroblasts. Myofibroblast-related genes proteins were also down-regulated, indicating decrease risk scar formation. Furthermore, accelerated while achieving highly organized extracellular vivo. Conclusion Consequently, suggested not only delivery vehicle but protein stabilizer for effective
Language: Английский
Citations
13
Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(12), P. 3009 - 3028
Published: Jan. 1, 2024
Biological barriers in the central nervous system.
Language: Английский
Citations
5
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(6), P. 1665 - 1680
Published: May 10, 2024
Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due the difficulty delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, enhanced bioavailability over conventional drugs, are garnering attention for spinal treatment. This review explores current mechanisms shortcomings existing treatments, highlighting benefits progress nanoparticle-based approaches. We detail nanoparticle methods injury, including local intravenous injections, oral delivery, biomaterial-assisted implantation, alongside strategies such as drug loading surface modification. The discussion extends how nanoparticles aid reducing oxidative stress, dampening inflammation, fostering regeneration, promoting angiogenesis. summarize use various types treating injuries, metallic, polymeric, protein-based, inorganic non-metallic, lipid nanoparticles. also discuss faced, biosafety, effectiveness humans, precise dosage control, standardization production characterization, immune responses, vivo. Additionally, we explore future directions, improving standardizing manufacturing characterization processes, advancing human trials. Nanoparticles have shown considerable enhancing treatment efficacy potential clinical development.
Language: Английский
Citations
5
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101452 - 101452
Published: Jan. 5, 2025
Scaffolded-spheroids represent novel building blocks for bottom-up tissue assembly, allowing to produce constructs with high initial cell density. Previously, we demonstrated the successful differentiation of such blocks, produced from immortalized human adipose-derived stem cells, towards different phenotypes, and possibility creating macro-sized tissue-like in vitro. The culture cells vitro depends on supply various nutrients biomolecules, as growth factors, usually supplemented medium. Another means factor delivery (in vivo) is release scaffold alter biological response surrounding (e.g. by VEGF).1 As a proof concept this approach, sought biofunctionalize surface microscaffolds heparin "universal linker" that would allow binding variety factors/biomolecules. An aminolysis step an organic solvent made it possible generate hydrophilic charged surface. backbone amine, well reaction conditions, led adjustable modification. amount was increased ethylene glycol-based diamine varied between 8 40 ng per microscaffold. Choosing suitable linker allows easy adjustment loading VEGF other heparin-binding proteins. Initial results indicated up 5 could be loaded microscaffold, generating steady 16 days. We report easy-to-perform, scalable modification approach polyester-based resin leads concentrations heparin. opens route modifications broadens spectrum biomolecules which can delivered.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101518 - 101518
Published: Jan. 23, 2025
Spinal cord injury (SCI) is significantly hampered by an inflammatory microenvironment, prompting continued efforts in drug development to address inflammation. Research shows that quercetin (Que) exhibits excellent performance reducing inflammation and neuroprotection. However, its application limited poor solubility, notable side effects, the unique pathophysiology of spinal cord. In this study, we introduce a novel multifunctional liposome hydrogel delivery system (QLipTC@HDM), obtained incorporating liposomes with blood-spinal barrier penetration site targeting properties (LipTC) into dual-network viscous (HDM). Our results demonstrate encapsulating Que LipTC (QLipTC) enhances minimizes toxic facilitates lesion targeting, aids crossing barrier. Moreover, encapsulation HDM prolongs retention QLipTC at after local administration. Crucially, our findings reveal QLipTC@HDM induces M2 phenotype transformation glial cells mice SCI, thereby mitigating This intervention additionally preserves integrity barrier, optimizes reduces scarring, promotes axonal regeneration, motor function recovery SCI mice. summary, investigations highlight potential disease-specific as promising therapeutic approach for treatment management SCI.
Language: Английский
Citations
0
Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)
Published: Feb. 1, 2025
ABSTRACT The objective of a regenerative medicine is to repair, restore, and regenerate tissues organs that occurred due injury or defect disease. Additionally, the purpose reverse aging process body by utilizing body's innate healing ability. There still significant venture needs be directed for advancement in arena medicine, which makes use products derived from cell therapy as well biomedical. Stem cells growth factors are primary components medicine; hence, novel drug delivering systems now being studied augment transport active pharmaceuticals. Lipid‐based complexed with therapeutics suited site‐specific controlled release. Lipids biocompatible available various sources molecular weights self‐assemble into forms hydrophilic hydrophobic parts. By enhancing plasma membrane fluidity, excipients such non‐ionic surfactants, fatty acids, glycerides increase permeability. Liposomes, nanoparticles, nano‐emulsions, micelles nano‐lipid carriers can improve bioavailability both lipophilic medicines. lipoidal‐polymeric had emerged promising multifaceted application cytocompatibility, ecofriendly, ability encapsulate variety drugs. Further, treatment biomedical tissue engineering, rapidly developing discipline. Furthermore, similar vein, delivery technologies combined stem promote engraftment, differentiation, survival. Hence colloidal carrier has impending versatile applications. Therefore, review offer an abridged information on significance technology offering confined ecosystem facilitates them thrive distinguish effective manner.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101556 - 101556
Published: Feb. 4, 2025
Spinal cord injury (SCI) presents a formidable challenge in clinical settings, resulting sensory and motor function loss imposing significant personal societal burdens. However, owning to the adverse microenvironment limited regenerative capacity, achieving complete functional recovery after SCI remains elusive. Additionally, traditional interventions including surgery medication have series of limitations that restrict effectiveness treatment. Recently, tissue engineering (TE) has emerged as promising approach for promoting neural regeneration SCI, which can effectively delivery drugs into site cells improve survival differential. Here, we outline main pathophysiology events post injury, further discuss materials common assembly strategies used scaffolds treatment, expound on latest advancements treatment methods based drug cell detail, propose future directions repair with TE highlight potential applications.
Language: Английский
Citations
0
Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 131 - 181
Published: Jan. 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150453 - 150453
Published: March 15, 2024
Language: Английский
Citations
3