Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: May 14, 2024

Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and impaired restoration of deficiencies are major challenges treatment. Microbes have evolved numerous mechanisms to effectively evade host intrinsic adaptive immune attacks persistently localize the host, such as drug-resistant bacteria, biofilms, persister cells, intracellular small colony variants (SCVs). Moreover, microbial-mediated dysregulation microenvironment impedes regeneration process, leading defect repair. Despite advances surgical strategies drug applications for treatment infections within last decade, remain clinical management. The development application tissue engineering materials provided new infections, but comprehensive review their research progress lacking. This discusses critical pathogenic microbes skeletal system immunomodulatory effects on regeneration, highlights prospects technologies infections. It will inform translation antimicrobial repair management

Language: Английский

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Metal‐Phenolic Nanocapsules with Photothermal Antibacterial and Ros Scavenging Ability for Diabetic Wound Healing

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(10)

Published: Jan. 2, 2024

The presence of bacteria in diabetic wounds not only leads to the formation biofilms but also triggers oxidative stress and inflammatory responses, which hinder wound-healing process. Therefore, it is imperative formulate a comprehensive strategy that can proficiently eliminate enhance wound microenvironment. Herein, this work develops multifunctional metal-phenolic nanozymes (TA-Fe/Cu nanocapsules), wherein one-pot coordination tannic acid (TA)and Fe

Language: Английский

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Antimicrobial Activities of Natural Bioactive Polyphenols

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 718 - 718

Published: May 27, 2024

Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety biological functions natural environment. These uses include polyphenols food, beauty products, dietary supplements, and medicinal products grown rapidly during past 20 years. Antimicrobial described together with their sources, classes, subclasses. Polyphenols found different such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples benefits antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, antimicrobe properties. From these classes helpful for growth internal functional systems human body, providing healthy fats, vitamins, minerals, lowering risk cardiovascular diseases, improving brain health, rebooting our cellular microbiome health by mitochondrial uncoupling. Among various (curcumin, naringenin, quercetin, catechin, etc.) primarily antimicrobial activities discussed along possible future applications. For agents to be proven safe, adverse impacts must substantiated reliable scientific research well vitro vivo clinical data. Future may influenced this evaluation.

Language: Английский

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Antimicrobial Phenolic Materials: From Assembly to Function

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

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Green Nanotechnology: Naturally Sourced Nanoparticles as Antibiofilm and Antivirulence Agents Against Infectious Diseases

International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.

Language: Английский

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A review on recent trends of the antibacterial nonwovens air filter materials: Classification, fabrication, and application

Separation and Purification Technology, Journal Year: 2023, Volume and Issue: 330, P. 125404 - 125404

Published: Oct. 18, 2023

Language: Английский

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Antimicrobial activities of natural flavonoids against foodborne pathogens and their application in food industry

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140476 - 140476

Published: July 15, 2024

Language: Английский

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Food-packaging applications and mechanism of polysaccharides and polyphenols in multicomponent protein complex system: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132513 - 132513

Published: May 21, 2024

Language: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

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Polyphenol‐Modified Mg−Zn Layered Hydroxide‐Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Diabetic oral ulcers pose a significant challenge in healing due to persistent inflammation. Despite local therapeutic interventions remaining the primary mode of treatment, dynamic nature cavity, characterized by continuous muscular activity and salivary secretion, poses barriers sustained drug retention thereby limits efficacy. To address this issue, an approach has been devised that aims facilitate transdermal delivery bioactive components promote diabetic ulcers. A multifunctional soluble microneedle (MN) patch is prepared using γ‐polyglutamic acid (γ‐PGA), which loaded with quercetin (Qu)‐modified Mg−Zn layered hydroxide salt (LHS) nanosheets (LHSQ) anti‐inflammatory, antimicrobial pro‐angiogenic bioactivities combat These findings demonstrate LHSQ‐loaded MN (LHSQ‐MN) patches are capable effectively penetrating mucosa. In rat model ulcers, application LHSQ‐MN found establishment regeneration sites, regulate inflammatory microenvironment damaged tissues, exhibit potent antibacterial effects, expedite reconstitution mucosal epithelium, accelerate ulcer through promotion angiogenesis. outcomes highlight potential as promising strategy for management patients.

Language: Английский

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