Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 5, 2024
Tannic
acid
(TA)
is
a
potent
antitumor
agent,
but
its
low
bioavailability
and
absorption
limit
use.
In
this
study,
it
was
loaded
into
chitosan-based
nanoparticles
(Chi-NPs)
to
overcome
these
limitations
improve
antimicrobial
anticancer
activities.
TA-loaded
Chi-NPs
(Chi-TA-NPs)
were
synthesized
using
the
ionic
gelation
method
physicochemically
characterized
by
FE-SEM,
FTIR,
XRD,
PDI,
DLS,
zeta
potential
analysis.
Additionally,
activity
of
Chi-TA-NPs
against
two
G+
bacterial
strains,
G-
fungal
strain
(Candida
albicans)
investigated
microbroth
dilution
method.
MTT
assay
used
examine
cytotoxic
effects
on
HepG2
cells.
The
expression
DNA
methyltransferase
1
(DNMT1),
DNMT3A,
DNMT3B
examined
in
cells
RT-qPCR.
amount
5-methylcytosine
cell-derived
genomic
measured
ELISA.
FE-SEM
micrographs
showed
loading
TA
formulation.
peaks
detected
XRD
FTIR
analyses
confirmed
formation
Chi-TA-NPs.
PDI
value
(0.247
±
0.03),
size
(567.0
25.84
nm),
(17.0
5.86
mV)
relative
stability
A
constant
release
profile
line
with
Korsmeyer-Peppas
model
for
Chi-TA-NPs,
such
that
approximately
44%
released
after
300
min.
addition,
exhibited
effective
studied
microbial
as
manifested
MIC
values
ranging
from
250
1000
µg/mL.
induced
cytotoxicity
liver
tumor
cell
line,
an
IC50
500
Furthermore,
considerably
decreased
DNMT1
(2.52-fold;
p
=
0.01),
DNMT3A
(2.96-fold;
0.004),
(2.94-fold;
<
0.0001).
However,
levels
unaffected
treatment
(p
0.62).
Finally,
antimicrobial,
cytotoxic,
epigenetic
more
pronounced
than
those
free
unloaded
Chi-NPs.
conclusion,
exhibit
promising
reducing
growth
promoting
cancer
Bone Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: May 14, 2024
Osteomyelitis
is
a
devastating
disease
caused
by
microbial
infection
in
deep
bone
tissue.
Its
high
recurrence
rate
and
impaired
restoration
of
deficiencies
are
major
challenges
treatment.
Microbes
have
evolved
numerous
mechanisms
to
effectively
evade
host
intrinsic
adaptive
immune
attacks
persistently
localize
the
host,
such
as
drug-resistant
bacteria,
biofilms,
persister
cells,
intracellular
small
colony
variants
(SCVs).
Moreover,
microbial-mediated
dysregulation
microenvironment
impedes
regeneration
process,
leading
defect
repair.
Despite
advances
surgical
strategies
drug
applications
for
treatment
infections
within
last
decade,
remain
clinical
management.
The
development
application
tissue
engineering
materials
provided
new
infections,
but
comprehensive
review
their
research
progress
lacking.
This
discusses
critical
pathogenic
microbes
skeletal
system
immunomodulatory
effects
on
regeneration,
highlights
prospects
technologies
infections.
It
will
inform
translation
antimicrobial
repair
management
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(10)
Published: Jan. 2, 2024
The
presence
of
bacteria
in
diabetic
wounds
not
only
leads
to
the
formation
biofilms
but
also
triggers
oxidative
stress
and
inflammatory
responses,
which
hinder
wound-healing
process.
Therefore,
it
is
imperative
formulate
a
comprehensive
strategy
that
can
proficiently
eliminate
enhance
wound
microenvironment.
Herein,
this
work
develops
multifunctional
metal-phenolic
nanozymes
(TA-Fe/Cu
nanocapsules),
wherein
one-pot
coordination
tannic
acid
(TA)and
Fe
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 718 - 718
Published: May 27, 2024
Secondary
metabolites,
polyphenols,
are
widespread
in
the
entire
kingdom
of
plants.
They
contain
one
or
more
hydroxyl
groups
that
have
a
variety
biological
functions
natural
environment.
These
uses
include
polyphenols
food,
beauty
products,
dietary
supplements,
and
medicinal
products
grown
rapidly
during
past
20
years.
Antimicrobial
described
together
with
their
sources,
classes,
subclasses.
Polyphenols
found
different
such
as
dark
chocolate,
olive
oil,
red
wine,
almonds,
cashews,
walnuts,
berries,
green
tea,
apples,
artichokes,
mushrooms,
etc.
Examples
benefits
antiallergic,
antioxidant,
anticancer
agents,
anti-inflammatory,
antihypertensive,
antimicrobe
properties.
From
these
classes
helpful
for
growth
internal
functional
systems
human
body,
providing
healthy
fats,
vitamins,
minerals,
lowering
risk
cardiovascular
diseases,
improving
brain
health,
rebooting
our
cellular
microbiome
health
by
mitochondrial
uncoupling.
Among
various
(curcumin,
naringenin,
quercetin,
catechin,
etc.)
primarily
antimicrobial
activities
discussed
along
possible
future
applications.
For
agents
to
be
proven
safe,
adverse
impacts
must
substantiated
reliable
scientific
research
well
vitro
vivo
clinical
data.
Future
may
influenced
this
evaluation.
Angewandte Chemie International Edition,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
International Journal of Microbiology,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
The
escalating
threat
of
infectious
diseases,
exacerbated
by
antimicrobial
resistance
(AMR)
and
biofilm
formation,
necessitates
innovative
therapeutic
strategies.
This
review
presents
a
comprehensive
exploration
the
potential
nanoparticles
synthesized
from
natural
sources,
including
plant
extracts,
microbial
products,
marine
compounds,
as
agents.
These
naturally
derived
demonstrated
significant
antibiofilm
antivirulence
effects,
with
specific
examples
revealing
their
capacity
to
reduce
mass
up
78%
inhibit
bacterial
quorum
sensing
65%.
integration
bioactive
such
polyphenols
chitosan,
facilitates
nanoparticle
stability
enhances
efficacy,
while
green
synthesis
protocols
environmental
risks.
Notably,
identifies
silver
using
tea
achieving
85%
inhibition
polymicrobial
growth
in
vitro.
Despite
these
promising
results,
challenges
standardization
scalability
persist.
study
underscores
transformative
leveraging
sourced
sustainable
alternatives
conventional
antimicrobials,
offering
quantitative
insights
for
future
application
combating
mono-
infections.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101553 - 101553
Published: Feb. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
