Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Intervertebral
disc
degeneration
(IVDD)
is
characterized
by
fibrosis
of
nucleus
pulposus
(NP)
cells
and
accelerated
surrounding
extracellular
matrix
catabolism.
Bioactive
hydrogels
have
shown
significant
potential
in
regulating
cellular
functions
tissue
homeostasis.
In
this
work,
a
dynamic
hydrogel
(HA-NCSN/Cu)
designed
via
the
reductive
chelation
hyaluronic
acid
grafted
with
thiourea
(HA-NCSN)
Cu
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 51 - 71
Published: March 15, 2024
Intervertebral
disc
degeneration
(IVDD)
can
be
caused
by
aging,
injury,
and
genetic
factors.
The
pathological
changes
associated
with
IVDD
include
the
excessive
accumulation
of
reactive
oxygen
species
(ROS),
cellular
pyroptosis,
extracellular
matrix
(ECM)
degradation.
There
are
currently
no
approved
specific
molecular
therapies
for
IVDD.
In
this
study,
we
developed
a
multifunctional
microenvironment-responsive
metal-phenolic
network
release
platform,
termed
TMP@Alg-PBA/PVA,
which
could
treat
(IL-1β)-induced
(TA-Mn-PVP,
TMP)
released
from
platform
targeted
mitochondria
to
efficiently
scavenge
ROS
reduce
ECM
Pyroptosis
was
suppressed
through
inhibition
IL-17/ERK
signaling
pathway.
These
findings
demonstrate
versatility
platform.
And
in
rat
model
IVDD,
TMP@Alg-PBA/PVA
exhibited
excellent
therapeutic
effects
reducing
progression
disease.
therefore,
presents
clinical
potential
treatment
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
202, P. 107119 - 107119
Published: Feb. 28, 2024
Intervertebral
disc
(IVD)
degeneration
is
a
frequent
cause
of
low
back
pain
and
the
most
common
disability.
Treatments
for
symptomatic
IVD
degeneration,
including
conservative
treatments
such
as
analgesics,
physical
therapy,
anti-inflammatories
surgeries,
are
aimed
at
alleviating
neurological
symptoms.
However,
there
no
effective
to
prevent
or
delay
degeneration.
Previous
studies
have
identified
risk
factors
aging,
inflammation,
genetic
factors,
mechanical
overload,
nutrient
deprivation
smoking,
but
metabolic
dysfunction
has
not
been
highlighted.
IVDs
largest
avascular
structures
in
human
body
determine
hypoxic
glycolytic
features
nucleus
pulposus
(NP)
cells.
Accumulating
evidence
demonstrated
that
intracellular
associated
with
comprehensive
review
lacking.
Here,
by
reviewing
physiological
IVDs,
pathological
processes
changes
functions
genes
we
highlight
pathway
intact
mitochondrial
function
essential
homeostasis.
In
degenerated
NPs,
glycolysis
downregulated.
Boosting
HIF1α
overexpression
protects
against
Moreover,
correlations
between
diseases
diabetes,
obesity
their
underlying
molecular
mechanisms
discussed.
Hyperglycemia
diabetic
leads
cell
senescence,
senescence-associated
phenotype
(SASP),
apoptosis
catabolism
extracellualr
matrix
IVDs.
Correcting
global
disorders
insulin
GLP-1
receptor
agonist
administration
beneficial
diabetes
Overall,
summarized
recent
progress
investigations
on
contributions
provide
new
perspective
correcting
may
be
treating
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 100985 - 100985
Published: Feb. 2, 2024
The
repair
of
critical-sized
bone
defects
poses
a
significant
challenge
due
to
the
absence
periosteum,
which
plays
crucial
role
in
coordinating
processes
osteogenesis
and
vascularization
during
healing.
Herein,
we
hypothesized
that
melatonin-encapsuled
silk
Fibronin
electrospun
nanofibers
(SF@MT)
could
provide
intrinsic
induction
both
angiogenesis,
thereby
promoting
vascularized
regeneration.
sustained
release
melatonin
from
SF@MT
resulted
favorable
biocompatibility
superior
osteogenic
marrow
mesenchymal
stem
cells
(BMMSCs).
Interestingly,
promoted
migration
tube
formation
human
umbilical
vein
endothelial
(HUVECs)
BMMSC-dependent
manner,
potentially
through
upregulation
vascular
growth
factor
(VEGFA)
expression
SF@MT-cultured
BMMSCs.
enhanced
BMMSC-mediated
angiogenesis
by
activating
PI3K/Akt
signaling
pathway.
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Journal Year:
2025,
Volume and Issue:
113(2)
Published: Jan. 22, 2025
ABSTRACT
Intervertebral
disc
degeneration
(IDD)
is
one
of
the
leading
causes
chronic
pain
and
disability,
traditional
treatment
methods
often
struggle
to
restore
its
complex
biomechanical
properties.
This
article
explores
innovative
application
self‐healing
hydrogels
in
IDD,
offering
new
hope
for
repair
due
their
exceptional
self‐repair
capabilities
adaptability.
As
a
key
support
structure
human
body,
intervertebral
discs
are
damaged
by
trauma
or
degenerative
changes.
Self‐healing
not
only
mimic
mechanical
properties
natural
but
also
when
damaged,
thereby
maintaining
stable
functionality.
reviews
mechanisms
design
strategies
and,
first
time,
outlines
potential
IDD.
Furthermore,
looks
forward
future
developments
field,
including
intelligent
material
design,
multifunctional
integration,
encapsulation
release
bioactive
molecules,
combinations
with
tissue
engineering
stem
cell
therapy,
perspectives
IDD
treatment.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Circadian
rhythm
disruption,
commonly
caused
by
factors
such
as
jet
lag
and
shift
work,
is
increasingly
recognized
a
critical
factor
impairing
wound
healing.
Although
melatonin
known
to
regulate
circadian
rhythms
has
potential
in
repair,
its
clinical
application
limited
low
bioavailability.
To
address
these
challenges,
we
developed
an
alginate-based
dual-network
hydrogel
delivery
system
for
melatonin,
ensuring
stable
sustained
release
at
the
site.
This
approach
enhances
efficacy
of
modulating
healing
process.
We
investigated
effects
disruption
on
microenvironment
under
influence
melatonin-loaded
with
focus
biocompatibility,
hemostatic
properties,
antioxidant
response
functions.
Additionally,
elucidated
mechanisms
which
promotes
Our
findings
provide
insights
into
relationship
between
healing,
offering
promising
strategy
management
chronic
wounds
associated
disorders.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4858 - 4858
Published: April 29, 2024
Melatonin
and
sericin
exhibit
antioxidant
properties
may
be
useful
in
topical
wound
healing
patches
by
maintaining
redox
balance,
cell
integrity,
regulating
the
inflammatory
response.
In
human
skin,
melatonin
suppresses
damage
caused
ultraviolet
radiation
(UVR)
which
involves
numerous
mechanisms
associated
with
reactive
oxygen
species/reactive
nitrogen
species
(ROS/RNS)
generation
enhancing
apoptosis.
Sericin
is
a
protein
mainly
composed
of
glycine,
serine,
aspartic
acid,
threonine
amino
acids
removed
from
silkworm
cocoon
(particularly
Bombyx
mori
other
species).
It
interest
because
its
biodegradability,
anti-oxidative,
anti-bacterial
properties.
inhibits
tyrosinase
activity
promotes
proliferation
that
can
supportive
melanoma
treatment.
recent
years,
containing
individually
have
attracted
significant
attention
scientific
community.
this
review,
we
summarize
state
innovation
such
during
2021–2023.
To
date,
melatonin/sericin-polymer
for
application
post-operational
treatment
has
been
only
sparingly
investigated
it
an
imperative
to
consider
these
materials
as
promising
approach
targeting
skin
tissue
engineering
or
regenerative
dermatology.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(49), P. 47964 - 47975
Published: Nov. 21, 2024
Tissue
repair
is
an
extremely
complex
process,
and
effectively
promoting
tissue
regeneration
remains
a
significant
clinical
challenge.
Hydrogel
materials,
which
exhibit
physical
properties
closely
resembling
those
of
living
tissues,
including
high
water
content,
oxygen
permeability,
softness,
have
the
potential
to
revolutionize
field
repair.
However,
presence
various
conditions,
such
as
infection,
ischemia,
hypoxia
in
defects,
means
that
hydrogels
with
simple
structures
functions
are
often
insufficient
meet
diverse
needs
Researchers
focused
on
integrating
multiple
drugs,
nanomaterials,
bioactive
substances,
stem
cells
into
hydrogel
matrices
develop
novel
multifunctional
composite
for
addressing
these
challenges,
superior
antibacterial
properties,
hemostatic
abilities,
self-healing
capacities,
excellent
mechanical
properties.
These
designed
enhance
become
important
direction
current
research.
This
review
provides
comprehensive
recent
advances
application
repair,
drug-loaded
hydrogels,
nanomaterial
substance
cell
hydrogels.
