Biosensors,
Journal Year:
2023,
Volume and Issue:
13(3), P. 346 - 346
Published: March 4, 2023
With
the
increasing
number
of
patients
suffering
from
Parkinson's
disease,
importance
measuring
drug
levels
in
patient
body
fluids
has
increased
exponentially,
particularly
for
clozapine.
There
is
a
growing
demand
real-time
analysis
biofluids
on
single
low-cost
platform
ultra-low
fluid
volumes
with
robustness.
This
study
aims
to
measure
level
clozapine
(Clz)
portable
potentiostat
using
practical
approach.
For
this
purpose,
we
developed
an
inexpensive,
via
electrochemistry
commercial
glucose
test
strip
(CTS).
CTSs
were
first
modified
by
removing
enzyme
mixture
surface
sensing
zone,
which
was
followed
modification
Multi
walled
carbon
nanotube
(MWCNT)
and
Nafion.
The
electrochemical
characteristics
CTS
electrodes
investigated
cyclic
voltammetry
(CV)
differential
(DPV)
techniques.
designed
sensor
displayed
decent
linear
range,
detection
limit,
reproducibility,
reusability
results.
A
dynamic
range
0.1-5
μM
observed
under
optimized
conditions
good
sensitivity
(1.295
μA/μM)
limit
(83
nM).
Furthermore,
electrode
used
amount
Clz
real
samples.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(26), P. 12586 - 12598
Published: Jan. 1, 2024
In
situ
monitoring
of
H2O2
in
cellular
microenvironments
plays
a
critical
role
the
early
diagnosis
and
pretreatment
cancer,
but
is
limited
by
lack
efficient
low-cost
strategies
for
large-scale
preparation
real-time
biosensors.
Herein,
universal
strategy
MXene-based
composite
inks
combined
with
scalable
screen-printing
process
validated
manufacturing
electrochemical
biosensors
detection
secreted
from
live
cells.
Compositing
biocompatible
carboxymethyl
cellulose
(CMCS)
excellent
conductive
MXene,
water-based
ink
electrode
(MXene/CMCS)
tunable
viscosity
efficiently
printed
desirable
printing
accuracy.
Subsequently,
MXene/CMCS@HRP
biosensor
exhibits
stable
performance
through
HRP
nanoflower
modification,
showing
rapid
electron
transport
high
electrocatalytic
capacity,
demonstrating
low
limit
(0.29
μM)
wide
linear
range
(0.5
μM-3
mM),
superior
sensitivity
(56.45
μA
mM-1
cm-2),
long-term
stability
anti-interference
ability.
Moreover,
this
effectively
employed
HeLa
cells,
revealing
good
biocompatibility
outstanding
biosensing
capability.
This
proposed
not
only
extends
possibility
biomedical
devices,
also
provides
promising
approach
treatment
cancer.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(3), P. 166 - 166
Published: March 4, 2025
In
recent
decades,
the
utilization
of
biomarkers
has
gained
increasing
attention.
The
timely
identification
and
quantification
proteins,
nucleic
acids,
small
molecules
associated
with
a
medical
condition,
infection,
or
contaminant
have
become
increasingly
crucial
across
variety
fields,
including
medicine,
food
safety,
quality/environmental
control.
State-of-the-art
biomarker
detection
methods
predominantly
rely
on
standard
immunoassay
techniques,
requiring
specialized
laboratory
equipment
trained
personnel.
This
impedes
broad
commercial
implementation
biosensors
in,
e.g.,
Point-of-Care
(PoC)
settings
where
ease
operation,
portability,
cost-efficiency
are
prioritized.
Small,
robust
electrochemical
promising
alternative
for
analyzing
in
complex
samples
within
PoC
environments.
Therefore,
creating
designing
optimized
sensing
surfaces,
immobilization
strategies,
efficient
signal
generation
improving
biosensor
systems,
which
turn
can
real-world
impact.
present
paper,
we
reviewed
common
electrode
types
geometries
used
approaches,
discussed
advantages
drawbacks
different
methods,
presented
labeling
strategies
enhancement.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(4), P. 210 - 210
Published: March 25, 2025
In
this
literature
review,
methods
for
the
detection
of
breast
cancer
biomarkers
and
operation
electrochemical
sensors
are
considered.
The
work
in
determination
was
systematized,
a
comparative
table
with
other
compiled,
as
classification
depending
on
their
intended
use.
various
traditional
diagnosis
described,
including
mammography,
ultrasound,
magnetic
resonance
imaging,
positron
emission
computed
tomography,
single-photon
biopsy,
advantages
disadvantages
presented.
Key
sensor
parameters
compared,
such
limit,
linear
range,
response
time,
sensitivity,
characteristics
analyte
being
analyzed.
Based
reviewed
scientific
papers,
significance
detecting
is
demonstrated.
types
tumor
identified
by
biosensors
were
analyzed,
particular
focus
HER2.
Studies
HER2
using
compared
features
determining
biomarker
characterized.
Possible
interfering
agents
affecting
accuracy
under
experimental
conditions
considered,
mechanisms
action
ways
to
eliminate
them
proposed.
This
report
provides
summary
current
aspects
research
biomarkers.
development
opens
up
new
prospects
early
prognosis
treatment.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
cost-effective,
ultrasensitive
electrochemical
aptasensor
using
V
2
CT
x
MXene
is
developed
for
real-time,
point-of-care
HER-2
breast
cancer
detection,
offering
high
sensitivity,
selectivity,
and
suitability
resource-limited
settings.
