Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

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Nanomaterials-assisted photothermal therapy for breast cancer: State-of-the-art advances and future perspectives

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 45, P. 103959 - 103959

Published: Jan. 21, 2024

Breast cancer (BC) remains an enigmatic fatal modality ubiquitously prevalent in different parts of the world. Contemporary medicines face severe challenges remediating and healing breast cancer. Due to its spatial specificity nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down lane. PTT utilizes a near-infrared (NIR) light source irradiate tumor target intravenously or non-invasively, which is converted into heat energy over optical fibre. Dynamic progress nanomaterial synthesis was achieved with specialized visual, physicochemical, biological, pharmacological features make up for inadequacies expand horizon PTT. Numerous nanomaterials have substantial NIR absorption can function as efficient transducers. It achievable limit wavelength range absorbance peak specific by manipulating their synthesis, enhancing precision quality Along same lines, various are conjugated wide surface-modifying chemicals, including polymers antibodies, may modify persistence diminish toxicity concerns. In this article, we tend put forth insights fundamental conceptualizations on pre-existing advances upon conjugation biocompatible working synergy combat cancer, encompassing several strategies like immunotherapy, chemotherapy, photodynamic therapy, radiotherapy coupled Additionally, role mechanisms nanoparticles, well possible alternatives PTT, summarized distinctive integral aspect article.

Language: Английский

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Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112983 - 112983

Published: March 26, 2024

Language: Английский

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Nanomaterial surface modification toolkit: Principles, components, recipes, and applications

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 322, P. 103035 - 103035

Published: Nov. 3, 2023

Surface-functionalized nanostructures are at the forefront of biotechnology, providing new opportunities for biosensors, drug delivery, therapy, and bioimaging applications. The modification significantly impacts performance success various applications by enabling selective precise targeting. This review elucidates widely practiced surface strategies, including click chemistry, cross-coupling, silanization, aldehyde linkers, active ester maleimide epoxy other protein DNA-based methodologies. We also delve into application-focused landscape nano-bio interface, emphasizing four key domains: therapeutics, biosensing, environmental monitoring, point-of-care technologies, highlighting prominent studies. insights presented herein pave way further innovations intersection nanotechnology a useful handbook beginners professionals. draws on sources, latest research articles (2018-2023), to provide comprehensive overview field.

Language: Английский

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Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

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Nanotechnology development in surgical applications: recent trends and developments

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Nov. 24, 2023

Abstract This paper gives a detailed analysis of nanotechnology's rising involvement in numerous surgical fields. We investigate the use nanotechnology orthopedic surgery, neurosurgery, plastic oncology, heart vascular ophthalmic thoracic and minimally invasive surgery. The details how helps with arthroplasty, chondrogenesis, tissue regeneration, wound healing, more. It also discusses employment nanomaterials implant surfaces, bone grafting, breast implants, among other things. article explores various uses, including stem cell-incorporated nano scaffolds, nano-surgery, hemostasis, nerve nanorobots, diagnostic applications. ethical safety implications using surgery are addressed. future possibilities investigated, pointing to possible route for improved patient outcomes. essay finishes comment on transformational influence applications its promise breakthroughs. Graphical

Language: Английский

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Multifunctional Carbon-Based Nanoparticles: Theranostic Applications in Cancer Therapy and Diagnosis

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(4), P. 1323 - 1338

Published: March 15, 2023

Cancer diagnosis and treatment are the most critical challenges in modern medicine. Conventional cancer treatments no longer meet needs of health field due to high rate mutations epigenetic factors that have caused drug resistance tumor cells. Hence, search for unique methods is quickly expanding. The development nanotechnology medicine a system integrate achieve an effective approach overcome known limitations conventional led emergence theranostic nanoparticles nanosystems based on these nanoparticles. An influential group carbon-based These received significant attention their properties, such as electrical conductivity, strength, excellent surface chemistry, wide range structural diversity (graphene, nanodiamond, carbon quantum dots, fullerenes, nanotubes, nanohorns). were widely used various fields, tissue engineering, delivery, imaging, biosensors. In this review, we discuss detail recent features advances advanced diverse strategies treat diseases with

Language: Английский

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Drug Delivery of Gelatin Nanoparticles as a Biodegradable Polymer for the Treatment of Infectious Diseases: Perspectives and Challenges

Polymers, Journal Year: 2023, Volume and Issue: 15(21), P. 4327 - 4327

Published: Nov. 5, 2023

In recent years, there has been a growing interest in the use of gelatin nanoparticles (GNPs) for treatment infectious diseases. The inherent properties these make them attractive options drug delivery. Their biocompatibility ensures that they can interact with biological systems without causing adverse reactions, while their biodegradability break down harmlessly body once function is performed. Furthermore, capacity controlled release therapeutic agents be delivered over sustained period, thereby enhancing efficacy. This review examines current landscape GNP-based delivery, specific focus on its potential applications and challenges context Key include controlling rates, ensuring nanoparticle stability under physiological conditions, scaling up production maintaining quality, mitigating immunogenic optimizing loading efficiency, tracking biodistribution clearance GNPs body. Despite hurdles, hold promising realm disease treatment. Ongoing research innovation are essential to overcome obstacles completely harness clinical applications.

Language: Английский

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A review on advancements in the application of starch-based nanomaterials in biomedicine: Precision drug delivery and cancer therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130746 - 130746

Published: March 11, 2024

Language: Английский

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Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials

Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 21, 2024

Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the potentials cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches major scientific databases, relevant studies published up March 2024 were included, focusing trials utilizing advanced for purposes. The discusses diverse applications oncology, infectious diseases, neurology, other medical fields. Additionally, it scrutinizes safety profiles, efficacy outcomes, challenges associated with nanoparticle-based therapies. findings underscore significant progress translating nanoparticle research into practice highlight potential these innovative platforms revolutionize treatments. contributes valuable insights growing field therapeutics, fostering deeper understanding implications practice.

Language: Английский

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