Journal of Analytical Oncology,
Journal Year:
2024,
Volume and Issue:
13, P. 36 - 42
Published: Dec. 4, 2024
Iron
oxide
nanoparticles
(IONPs)
have
shown
great
promise
in
targeted
cancer
therapy
due
to
their
unique
magnetic
properties
and
ability
be
functionalized
with
various
ligands.
This
study
explores
the
use
of
iron
macrocycle
antagonists
target
CXCR4
receptors
on
cells.
The
synthesis
superparamagnetic
(SPIONs)
was
validated
through
XRD
TEM
analyses,
which
showed
uniform,
roughly
spherical
particles.
Fluorescence-loaded
SPIONs
provided
enhanced
imaging
contrast
Jurkat
Flow
cytometry
demonstrated
that
effectively
blocked
receptors,
highlighting
potential
for
therapy.
These
findings
underscore
successful
synthesis,
characterization,
functionalization
SPIONs,
paving
way
advanced
nanomedicine
strategies
diagnostics
treatment.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(1), P. 24 - 24
Published: Jan. 14, 2025
Autoimmune
diseases
present
complex
therapeutic
challenges
due
to
their
chronic
nature,
systemic
impact,
and
requirement
for
precise
immunomodulation
avoid
adverse
side
effects.
Recent
advancements
in
biodegradable
stimuli-responsive
nanomaterials
have
opened
new
avenues
targeted
drug
delivery
systems
capable
of
addressing
these
challenges.
This
review
provides
a
comprehensive
analysis
state-of-the-art
nanocarriers
such
as
polymeric
nanoparticles,
liposomes,
hydrogels
engineered
autoimmune
therapies.
These
are
designed
degrade
safely
the
body
while
releasing
agents
response
specific
stimuli,
including
pH,
temperature,
redox
conditions,
enzymatic
activity.
By
achieving
localized
controlled
release
anti-inflammatory
immunosuppressive
agents,
minimize
toxicity
enhance
efficacy.
We
discuss
underlying
mechanisms
nanomaterials,
recent
applications
treating
rheumatoid
arthritis,
multiple
sclerosis,
inflammatory
bowel
disease,
design
considerations
essential
clinical
translation.
Additionally,
we
address
current
challenges,
biocompatibility,
scalability,
regulatory
hurdles,
well
future
directions
integrating
advanced
nanotechnology
with
personalized
medicine
treatment.
highlights
transformative
potential
presenting
them
promising
strategy
advance
precision
improve
patient
outcomes
disease
management.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 70 - 70
Published: Jan. 7, 2025
Malignant
growth
is
expected
to
surpass
other
significant
causes
of
death
as
one
the
top
reasons
for
dismalness
and
mortality
worldwide.
According
a
World
Health
Organization
(WHO)
study,
this
illness
approximately
between
9
10
million
instances
deaths
annually.
Chemotherapy,
radiation,
surgery
are
three
main
methods
treating
cancer.
These
seek
completely
eradicate
all
cancer
cells
while
having
fewest
possible
unintended
impacts
on
healthy
cell
types.
Owing
lack
target
selectivity,
majority
medications
have
substantial
side
effects.
On
hand,
nanomaterials
transformed
identification,
diagnosis,
management
Nanostructures
with
biomimetic
properties
been
grown
late,
fully
intent
observing
sickness.
nanostructures
be
consumed
by
in
areas
profound
disease.
Furthermore,
because
their
extraordinary
physicochemical
properties,
which
incorporate
nanoscale
aspects,
more
prominent
surface
region,
explicit
geometrical
features,
ability
embody
different
substances
within
or
outside
surfaces,
remarkable
nano-vehicles
conveying
restorative
specialists
designated
regions.
This
review
discusses
recent
developments
nanostructured
materials
such
graphene,
dendrimers,
cell-penetrating
peptide
nanoparticles,
nanoliposomes,
lipid
magnetic
nano-omics
diagnosis
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 281 - 281
Published: Feb. 20, 2025
The
blood–brain
barrier
(BBB)
is
a
critical
structure
that
maintains
brain
homeostasis
by
selectively
regulating
nutrient
influx
and
waste
efflux.
Not
surprisingly,
it
often
compromised
in
neurodegenerative
diseases.
In
addition
to
its
involvement
these
pathologies,
the
BBB
also
represents
significant
challenge
for
drug
delivery
into
central
nervous
system.
Nanoparticles
(NPs)
have
been
widely
explored
as
carriers
capable
of
overcoming
this
effectively
transporting
therapies
brain.
However,
their
potential
directly
address
ameliorate
dysfunction
has
received
limited
attention.
review,
we
examine
how
NPs
enhance
across
treat
diseases
explore
emerging
strategies
restore
integrity
vital
structure.
Biomimetics,
Journal Year:
2025,
Volume and Issue:
10(1), P. 25 - 25
Published: Jan. 3, 2025
Meningitis
is
the
acute
or
chronic
inflammation
of
protective
membranes,
surrounding
brain
and
spinal
cord,
this
inflammatory
process
spreads
throughout
subarachnoid
space.
The
traditional
drug
delivery
methods
pose
a
disadvantage
in
limiting
capacity
crossing
blood–brain
barrier
(BBB)
to
reach
central
nervous
system
(CNS).
Hence,
it
imperative
develop
novel
approaches
that
can
overcome
these
constraints
offer
efficient
therapy
for
meningitis.
Nanoparticle
(NP)-based
therapeutic
have
potential
address
limitations
such
as
penetrating
BBB
achieving
targeted
release
specific
cells
tissues.
This
review
highlights
recent
advancements
nanotechnology-based
approaches,
functionalized
polymeric
nanoparticles,
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers,
nanoemulsions,
liposomes,
transferosomes,
metallic
NPs
treatment
Recently,
bionics
has
emerged
next-generation
technology
development
ideas
from
biological
principles,
structures,
interactions
neurological
neuroinfectious
diseases.
Despite
their
potential,
more
studies
are
needed
ensure
safety
efficacy
NP-based
systems
focusing
on
critical
aspects
toxicity,
immunogenicity,
pharmacokinetics.
Therefore,
addresses
current
strategies
innovative
nanoparticle
discusses
future
directions
meningitis
therapies.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(4)
Published: Jan. 1, 2025
Abstract
The
increasing
use
of
metal
oxide
nanoparticles
demands
a
better
understanding
their
health
impact.
Here,
we
report
the
synthesis
copper
(I)
(Cu
2
O
NPs)
using
cost‐effective
chemical
methods
and
assessed
photocatalytic,
antibacterial,
anticancer
properties.
X‐ray
diffraction
(XRD)
pattern
verified
its
cubic
structure.
average
crystallite
size
11
nm
was
obtained
Scherrer
method.
Fourier
transform
infrared
(FTIR)
spectroscopy
confirmed
formation
Cu
NPs.
spherical
morphology
through
field
emission
scanning
electron
microscopy
(FESEM)
analysis.
High‐resolution
transmission
(HRTEM)
estimated
to
be
around
15
nm.
photoelectron
(XPS)
spectra
NPs
showed
peaks
at
931.75
951.82
eV,
corresponding
2p
3/2
1/2
,
respectively.
UV–vis
revealed
optical
direct
bandgap
(2.33
eV)
Under
light
irradiation,
catalyst
achieved
tetracycline
(TC)
degradation
efficiency
80%
within
75
min.
antibacterial
properties
against
Klebsiella
pneumoniae
Bacillus
subtilis
agar
disk
diffusion
have
been
investigated.
also
exhibited
significant
activity
MCF‐7
cancer
cells
MTT
assay,
with
an
IC
50
value
18.88
µg/mL.
Neuroglia,
Journal Year:
2025,
Volume and Issue:
6(1), P. 9 - 9
Published: Feb. 21, 2025
Background:
Neurological
disorders
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
stroke,
and
spinal
cord
injury
(SCI)
are
significant
global
health
challenges
due
to
their
complex
pathology
limited
therapeutic
options.
Conventional
treatments
often
fail
efficiently
cross
the
blood–brain
barrier
(BBB),
leading
poor
bioavailability
systemic
toxicity.
This
narrative
review
explores
potential
of
nanomedicine
in
addressing
these
limitations
advancing
targeted
therapies
for
neural
disorders.
Methods:
examines
recent
studies
on
use
engineered
nanoparticles
(NPs),
including
liposomes,
dendrimers,
micelles,
nanogels,
drug
delivery
multifunctional
theranostics
diseases.
It
evaluates
role
promoting
axon
regeneration,
reducing
neuroinflammation,
repairing
damage.
Additionally,
innovative
applications
gene
therapy
RNA-based
treatments,
CRISPR-Cas9
RNA
interference
(RNAi),
discussed.
Challenges
related
toxicity,
scalability,
affordability,
regulatory
barriers
highlighted,
along
with
strategies
address
issues.
Results:
Nanoparticles
have
shown
promise
crossing
BBB,
delivering
agents
tissues,
minimizing
off-target
effects.
Emerging
demonstrate
versatility
disease-specific
challenges.
However,
unresolved
issues
long-term
safety,
manufacturing
cost
continue
pose
Conclusions:
Nanomedicine
offers
a
promising
approach
overcoming
current
treatment
emphasizes
need
continued
interdisciplinary
efforts
translational
highlights
improve
outcomes
quality
life
patients
disorders,
SCI.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Biological
barriers
significantly
impede
the
delivery
of
nanotherapeutics
to
diseased
tissues,
diminishing
therapeutic
efficacy
across
pathologies
such
as
cancer
and
inflammatory
disorders.
Although
conventional
strategies
integrate
multifunctional
designs
molecular
components
into
nanomaterials
(NMs),
many
approaches
remain
insufficient
overcome
these
barriers.
Key
challenges,
including
inadequate
drug
accumulation
at
target
sites
nonspecific
biodistribution,
persist
in
nanotherapeutic
development.
NMs,
which
harness
ability
precisely
modulate
spatiotemporally
control
release
kinetics,
represent
a
transformative
platform
for
targeted
therapy.
In
this
review,
we
highlight
biological
obstacles
limiting
effective
treatment
evaluate
how
stimuli-responsive
NMs
address
constraints.
By
leveraging
exogenous
endogenous
stimuli,
improve
specificity,
reduce
off-target
effects,
amplify
activity
within
pathological
microenvironments.
We
systematically
analyze
rational
design
synthesis
driven
by
advances
oncology,
biomaterials
science,
nanoscale
engineering.
Furthermore,
NM
classes-including
polymeric,
lipid-based,
inorganic,
hybrid
systems
explore
functionalization
using
targeting
ligands,
antibodies,
biomimetic
coatings.
Diverse
are
evaluated,
small-molecule
prodrug
activation,
peptide-
protein-based
targeting,
nucleic
acid
payloads,
engineered
cell-mediated
transport.
Despite
promise
challenges
biocompatibility,
scalable
fabrication,
clinical
translation
must
be
addressed.
elucidating
structure-function
relationships
refining
stimulus-triggered
mechanisms,
pave
way
precision
oncology
strategies,
enabling
patient-specific
therapies
with
enhanced
safety.
This
interdisciplinary
insights
aims
catalyze
innovation
next-generation
nanomedicine
treatment.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
The
geriatric
population,
comprising
ages
65
and
above,
encounters
distinct
health
obstacles
because
of
physiological
changes
heightened
vulnerability
to
diseases.
New
technologies
are
being
investigated
tackle
the
intricate
requirements
this
population.
Recent
advancements
in
probiotics
nanotechnology
offer
promising
strategies
enhance
by
improving
nutrient
absorption,
modulating
gut
microbiota,
delivering
targeted
therapeutic
agents.
Probiotics
play
a
crucial
role
maintaining
homeostasis,
reducing
inflammation,
supporting
metabolic
functions.
However,
challenges
such
as
limited
viability
efficacy
harsh
gastrointestinal
conditions
hinder
their
potential.
Advanced
can
overcome
these
constraints
enhancing
through
nano-encapsulation,
controlled
delivery,
improvement
bioavailability.
This
review
explores
synergistic
potential
advanced
addressing
age-related
concerns.
It
highlights
key
developments
probiotic
formulations,
nano-based
delivery
systems,
combined
impact
on
health,
immunity,
neuroprotection.
convergence
represents
novel
transformative
approach
promoting
healthy
aging,
paving
way
for
innovative
interventions.
