Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 14, 2025

Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.

Language: Английский

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Unveiling Green Synthesis and Biomedical Theranostic paradigms of Selenium Nanoparticles (SeNPs) - A state-of-the-art comprehensive update

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124535 - 124535

Published: Aug. 1, 2024

The advancements in nanotechnology, pharmaceutical sciences, and healthcare are propelling the field of theranostics, which combines therapy diagnostics, to new heights; emphasizing emergence selenium nanoparticles (SeNPs) as versatile theranostic agents. This comprehensive update offers a holistic perspective on recent developments synthesis applications SeNPs, underscoring their growing importance nanotechnology healthcare. SeNPs have shown significant potential multiple domains, including antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic, wound healing, cytoprotective therapies. review highlights adaptability biocompatibility crucial for advanced disease detection, monitoring, personalized treatment. Special emphasis is placed green techniques, eco-friendly cost-effective benefits biosensing, imaging therapeutic applications. Additionally, appraisal scrutinizes progressive trends smart stimuli-responsive conferring role innovative solutions management diagnostics. Despite promising prophylactic potential, also present several challenges, particularly regarding toxicity concerns. These challenges implications clinical translation thoroughly explored, providing balanced view current state prospects

Language: Английский

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Enhanced pharmacokinetic approach for anastrozole in macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for estrogen-positive breast cancer therapy

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 3, 2025

Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) an effective orally administered hormonal therapy estrogen+ (ER+) BC treatment. However, several side effects and pharmacokinetic limitations restricted its uses in Therefore, this study developed

Language: Английский

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An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine. Graphical

Language: Английский

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Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 375 - 375

Published: March 15, 2025

Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions

Language: Английский

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Cubosomes-based hydrogels; A promising advancement for drug delivery

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125510 - 125510

Published: March 1, 2025

Language: Английский

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Green synthesized Pt-based nanoparticles redefining biomedical frontiers: A brief review

Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100613 - 100613

Published: March 27, 2025

Language: Английский

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Nanotechnology-Assisted mesenchymal stem cells treatment for improved cartilage regeneration: A review of current practices

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116895 - 116895

Published: March 1, 2025

Language: Английский

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Biofunctionalized agarose-based biopolymer composites for advanced biomedical applications: a review

Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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Carrageenan Modifications: Improving Biomedical Applications

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

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