Material Design, Fabrication Strategies, and the Development of Multifunctional Hydrogel Composites Dressings for Skin Wound Management

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The skin is fragile, making it very vulnerable to damage and injury. Untreated wounds can pose a serious threat human health. Three-dimensional polymer network hydrogels have broad application prospects in wound dressings due their unique properties structure. therapeutic effect of traditional limited, while multifunctional composite show greater potential. Multifunctional regulate moisture through formula adjustment. Moreover, be combined with bioactive ingredients improve performance healing applications. Stimulus-responsive respond specifically the environment meet needs different stages. This review summarizes material types, structure, properties, design considerations, formulation strategies for hydrogel used healing. We discuss various types recently developed dressings, highlights importance tailoring physicochemical addresses potential challenges preparing dressings.

Language: Английский

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Polyaminoglycoside nanosystem expressing antimicrobial peptides for multistage chronic wound management

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113657 - 113657

Published: March 1, 2025

Language: Английский

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Multifunctional alginate-sinapic acid/arginine-strontium hydrogel for promoting diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142460 - 142460

Published: March 1, 2025

Language: Английский

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Exudate management nonwovens loaded with Cirsium japonicum DC extract for enhanced hemostatic and wound healing

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114673 - 114673

Published: April 1, 2025

Language: Английский

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Injectable glycyrrhizic acid-based hydrogel with Immunoregulatory and angiogenic properties for diabetic wound healing

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113928 - 113928

Published: April 1, 2025

Language: Английский

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New Direction in Antimicrobial Delivery System: Preparation and Applications of Hydrogel Microspheres

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 529 - 529

Published: April 17, 2025

Antimicrobial delivery systems have undergone extensive development, yet conventional carriers still exhibit limitations such as low loading capacity, inadequate controlled release mechanisms, and cytotoxicity. Recent studies increasingly demonstrated the potential of Hydrogel Microspheres (HMSs) for antimicrobial delivery. These microspheres small dimensions, high drug-loading ability to achieve deep-targeted delivery, complemented by adjustable physicochemical properties biocompatibility that create favorable conditions transportation. This review systematically examines HMS preparation strategies, characteristic properties, transported antimicrobials, therapeutic applications. Particular emphasis is placed on critical parameters governing performance, especially those influencing drug dynamics. We conclude addressing current challenges proposing actionable strategies material optimization clinical translation. work aims advance HMS-based more effective infection control.

Language: Английский

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An Overview on Recent Progress of Microsphere‐Hydrogel Combination Systems as Scaffolds for Tissue Engineering

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract Tissue engineering aiming to develop and manufacture bioactive tissue or organ substitutes has been extensively studied. As an ideal scaffold material, the microsphere‐hydrogel combination system (MHCS), which combines excellent functionalities of hydrogels unique structural advantages microspheres, widely used in development biological for engineering. With adjustable mechanical properties, MHCS can simulate extracellular matrix‐like microstructure microenvironment conducive cell growth. These properties endow with repair, leading significant progress regeneration bone, skin, blood vessels, nerves, other tissues. In this paper, we reviewed latest construction based on natural polymers, synthetic inorganic materials, their composites. We also classified raw materials that were utilized microspheres discussed applications MHCS. Finally, challenges perspectives emphasized pointed out direction future development, such as conducted advanced processing technologies multidisciplinary cooperation solve limitations uneven microsphere distribution mismatched degradation rates, thus providing a reference design fabrication field

Language: Английский

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3D Electrospun nanofiber sponges of insect chitosan/pullulan/citric acid embedded with ZnMOF in situ for enhanced healing of MRSA-infected wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155388 - 155388

Published: Sept. 1, 2024

Language: Английский

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Preparation and characterization of pH-responsive Janus composite membranes with unidirectional moisture drainage and antioxidant resistance

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 701, P. 134916 - 134916

Published: July 24, 2024

Language: Английский

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A pro-healing short-chain antimicrobial peptide that inhibits sepsis

Science China Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

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