Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 18, 2022

Abstract Chemoresistance and metastasis are the major challenges for current ovarian cancer treatment. Understanding mechanisms of progression is critically important developing novel therapies. The advances in extracellular vesicles (EVs) research recent years have attracted extensive attention. EVs contain a variety proteins, RNAs, DNAs, metabolites. Accumulating evidence indicates that cells secrete large amount EVs, playing an role tumor recurrence. In microenvironment tumor, participate information transmission between stromal immune cells, promoting escape facilitating metastasis. Here, we review chemoresistance, metastasis, evasion cancer. Furthermore, also discuss EV future application as promising biomarker sources response to therapy therapy-delivery approaches patients.

Language: Английский

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Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications

Advanced Science, Journal Year: 2022, Volume and Issue: 9(34)

Published: Oct. 17, 2022

Abstract Extracellular vesicles (EVs) are cell‐derived nanosized that mediate cell‐to‐cell communication via transporting bioactive molecules and thus critically involved in various physiological pathological conditions. EVs contribute to different aspects of cancer progression, such as growth, angiogenesis, metastasis, immune evasion, drug resistance. induce the resistance cells chemotherapy, radiotherapy, targeted therapy, antiangiogenesis immunotherapy by transferring specific cargos affect efflux regulate signaling pathways associated with epithelial‐mesenchymal transition, autophagy, metabolism, stemness. In addition, modulate reciprocal interaction between noncancer tumor microenvironment (TME) develop therapy detectable many biofluids patients, regarded novel biomarkers for monitoring response predicting prognosis. Moreover, suggested promising targets engineered nanovehicles deliver drugs overcoming therapy. this review, biological roles their mechanisms action summarized. The preclinical studies on using also discussed.

Language: Английский

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The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 62, P. 100833 - 100833

Published: April 5, 2022

Drug resistance remains a major hurdle to successful cancer treatment, being accountable for approximately 90% of cancer-related deaths. In the past years, increasing attention has been given role extracellular vesicles (EVs) in horizontal transfer drug cancer. Indeed, many studies have described dissemination therapy traits mediated by EVs, which may be transferred from resistant tumor cells their sensitive counterparts. Importantly, different key players identified cargo those such as efflux pumps, oncoproteins, antiapoptotic proteins, or microRNAs, among others. Interestingly, EVs-mediated crosstalk between microenvironment (TME) and emerged another important mechanism that leads resistance. Recently, TME-derived EVs responsible also become focus attention. addition, possible mechanisms involved sequestration likely contribute resistance, are discussed herein. Despite latest scientific advances field this is still challenging area research, particularly clinical setting. Therefore, further investigation needed assess relevance failure patients identify biomarkers EV's cargo, develop effective therapeutic strategies surmount This up-to-date review summarizes relevant literature on competences cells, TME process. Finally, knowledge integrated with discussion future applications

Language: Английский

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Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer

Materials Today Bio, Journal Year: 2022, Volume and Issue: 13, P. 100218 - 100218

Published: Jan. 1, 2022

The grand challenges of ovarian cancer early diagnosis have led to an alarmingly high mortality rate from (OC) in the past half century. In vitro (IVD) has great potential OC through non-invasive and dynamic analysis biomarkers. However, common IVDs often fail provide reliable test results due lack sensitivity, specificity, convenience. recent years, discovery new biomarkers progress nanomaterials can solve shortcomings traditional IVD for OC. These emerging biosensors based on offer improvements convenience, speed, selectivity, sensitivity IVD. this review, we firstly systematically summarized limits commercial latest representative optimization strategies six are discussed with emphasis nanomaterial selection design detection principles. Then, various adopted by also introduced detail, including optical, electrochemical, microfluidic, surface plasmon sensors. Finally, current proposed, future research directions promising field discussed.

Language: Английский

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MicroRNAs in extracellular vesicles: A potential role in cancer progression

Cellular Signalling, Journal Year: 2024, Volume and Issue: 121, P. 111263 - 111263

Published: June 17, 2024

Language: Английский

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Exosomal miR-21-5p contributes to ovarian cancer progression by regulating CDK6

Human Cell, Journal Year: 2021, Volume and Issue: 34(4), P. 1185 - 1196

Published: April 3, 2021

Language: Английский

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Potential Role of Exosomes in the Chemoresistance to Gemcitabine and Nab-Paclitaxel in Pancreatic Cancer

Diagnostics, Journal Year: 2022, Volume and Issue: 12(2), P. 286 - 286

Published: Jan. 23, 2022

In recent years, a growing number of studies have evaluated the role exosomes in pancreatic ductal adenocarcinoma cancer (PDAC) demonstrating their involvement multitude pathways, including induction chemoresistance. The aim this review is to present an overview current knowledge on resistance gemcitabine and nab-paclitaxel, which are two most commonly used drugs for treatment PDAC patients. Exosomes vesicular cargos that transport multiple miRNAs, mRNAs proteins from one cell another some these factors can influence specific determinants activity, such as nucleoside transporter hENT1, or multidrug involved paclitaxel. Additional mechanisms underlying exosome-mediated include modulation apoptotic cellular metabolism, oncogenic miRNA, miR-21 miR-155. status circulating exosomal miRNA possible biomarkers also discussed. Finally, we integrated preclinical data with emerging clinical evidence, showing how study could help predict individual tumors, guide clinicians selection innovative therapeutic strategies overcome drug resistance.

Language: Английский

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Graphene oxide-based qRT-PCR assay enables the sensitive and specific detection of miRNAs for the screening of ovarian cancer

Analytica Chimica Acta, Journal Year: 2021, Volume and Issue: 1174, P. 338715 - 338715

Published: June 2, 2021

Language: Английский

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Extracellular Vesicle-Associated miRNAs and Chemoresistance: A Systematic Review

Cancers, Journal Year: 2021, Volume and Issue: 13(18), P. 4608 - 4608

Published: Sept. 14, 2021

Cancer is a leading public health issue globally, and diagnosis often associated with poor outcomes reduced patient survival. One of the major contributors to fatality resultant cancer development resistance chemotherapy, known as chemoresistance. Furthermore, there are limitations in our ability identify patients that will respond therapy, versus develop relapse, display limited or no response treatment. This leads being subjected multiple futile treatment cycles, results reduction their quality life. Therefore, an urgent clinical need tools at risk chemoresistance, recent literature has suggested small extracellular vesicles, exosomes, may be vital source information. Extracellular vesicles (EV) membrane bound involved cell-cell communication, through transfer cargo, which includes proteins, lipids, miRNAs. A defined exploration strategy was performed this systematic review order provide compilation key EV miRNAs predictive We searched PubMed, Science Direct, Scopus databases using following keywords: OR exosomes EVs AND miRNA Chemotherapy Chemoresistance Recurrence from 2010 2020. found 31 articles reported EV-associated recurrence related Interestingly, studies same tumor type identified different microRNAs, few ones. Specifically, miR-21, miR-222, miR-155 displayed roles were common colorectal cancer, ovarian breast diffuse large B cell lymphoma (DLBCL). miR-21 miR-222 favour whereas exhibited contrasting role, depending on primary tumor. Whilst high levels correlate chemotherapy DLBCL, it effective towards cancer. Thus, further research regarding these would beneficial terms designing novel counteract progression not-to-distant future.

Language: Английский

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Drug Resistance in Cancers: A Free Pass for Bullying

Cells, Journal Year: 2022, Volume and Issue: 11(21), P. 3383 - 3383

Published: Oct. 26, 2022

The cancer burden continues to grow globally, and drug resistance remains a substantial challenge in therapy. It is well established that cancerous cells with clonal dysplasia generate the same carcinogenic lesions. Tumor pass on genetic templates subsequent generations evolutionary terms exhibit simply by accumulating alterations. However, recent evidence has implied tumor accumulate alterations progressively adapting. As result, intratumor heterogeneity (ITH) generated due genetically distinct subclonal populations of coexisting. adaptive mechanisms action ITH include activating "cellular plasticity", through which create tumor-supportive microenvironment they can proliferate cause increased damage. These highly plastic are located (TME) undergo extreme changes resist therapeutic drugs. Accordingly, underlying involved have been re-evaluated. Herein, we will reveal new themes emerging from initial studies outline findings regarding perspective TME; exosomes, metabolic reprogramming, protein glycosylation autophagy, relates aim provide targets strategies for reversing cancers.

Language: Английский

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