Microfluidic Nanoparticles for Drug Delivery

Small, Journal Year: 2022, Volume and Issue: 18(36)

Published: April 9, 2022

Abstract Nanoparticles (NPs) have attracted tremendous interest in drug delivery the past decades. Microfluidics offers a promising strategy for making NPs due to its capability precisely controlling NP properties. The recent success of mRNA vaccines using microfluidics represents big milestone microfluidic pharmaceutical applications, and rapid scaling up demonstrates feasibility industrial‐scale manufacturing. This article provides critical review progress delivery. First, synthesis organic focusing on typical methods their applications popular clinically relevant NPs, such as liposomes, lipid polymer well mechanisms are summarized. Then, several representative inorganic (e.g., silica, metal, metal oxide, quantum dots), hybrid is discussed. Lastly, various presented.

Language: Английский

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Synergistic Effects Between Metal Nanoparticles and Commercial Antimicrobial Agents: A Review

ACS Applied Nano Materials, Journal Year: 2022, Volume and Issue: 5(3), P. 3030 - 3064

Published: March 4, 2022

Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, fundamental function novel medical devices. The combination MNPs with commercial drugs (e.g., antibiotics, antifungals, and antivirals) may offer several opportunities to overcome some disadvantages their individual use enhance effectiveness. MNP conjugates multiple advantages. As drug delivery systems, the can extend circulation in body, facilitate intercellular targeting, improve stabilization, possess superior delivery. Concomitantly, they reduce required dose, minimize toxicity, broaden spectrum. this work, common strategies combine clinically used agents are underscored. Furthermore, comprehensive survey about synergistic effects, mechanism action, cytotoxicity is depicted.

Language: Английский

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Thermal immuno-nanomedicine in cancer

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(2), P. 116 - 134

Published: Jan. 5, 2023

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

Small, Journal Year: 2021, Volume and Issue: 17(32)

Published: July 3, 2021

Chemodynamic therapy (CDT), which induces cell death by decomposing high levels of H2 O2 in tumor cells into highly toxic ·OH, is recognized as a promising antineoplastic approach. However, current CDT approaches are often restricted the controlled and upregulated cellular antioxidant defense. To enhance ·OH-induced damage CDT, covalent organic framework (COF)-based, ferrocene (Fc)- glutathione peroxidase 4 (GPX4) inhibitor-loaded nanodrug, RSL3@COF-Fc (2b), fabricated. The obtained 2b not only promotes situ Fenton-like reactions to trigger ·OH production cells, but also attenuates repair mechanisms under oxidative stress via irreversible GPX4 inhibition. As result, these two synergistically result massive lipid peroxide accumulation, subsequent damage, ultimately ferroptosis, while being limited intracellular glutathione. It believed that this research provides paradigm for enhancing reactive oxygen species-mediated oncotherapy through redox dyshomeostasis may provide new insights developing COF-based nanomedicine.

Language: Английский

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The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: March 12, 2022

Abstract Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of different materials and adjustment their physical chemical properties, nanoparticles can have diverse effects on organism may change treating paradigm multiple diseases future. More more results show that function as immunomodulators some formulas been approved for treatment inflammation-related diseases. However, our current understanding mechanisms influence immune responses still limited, systemic clinical trials are necessary evaluation security long-term effects. This review provides overview recent advances interact with cellular molecular components system application management inflammatory diseases, which caused by abnormal reactions. article focuses interaction between tries to provide a reference future design nanotechnology Graphical

Language: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

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The Antioxidant Effect of the Metal and Metal-Oxide Nanoparticles

Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 791 - 791

Published: April 18, 2022

Inorganic nanoparticles, such as CeO3, TiO2 and Fe3O4 could be served a platform for their excellent performance in antioxidant effect. They may offer the feasibility to further developed smaller controllable sizes, flexibility modified, relative low toxicity well ease of preparation. In this work, recent progress these nanoparticles were illustrated, mechanism inorganic introduced, which mainly included enzyme-mimetic activity ROS/RNS scavenging activity. The effects applications several Fe3O4, Se, are summarized paper. potential both vitro vivo was studied applications. Future directions how utilize applied some fields, medicine, cosmetic functional food additives also investigated

Language: Английский

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Engineering nanoparticle toolkits for mRNA delivery

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115042 - 115042

Published: Aug. 2, 2023

The concept of using mRNA to produce its own medicine in situ the body makes it an ideal drug candidate, holding great potential revolutionize way we approach medicine. unique characteristics mRNA, as well customizable biomedical functions, call for rational design delivery systems protect and transport molecules. In this review, a nanoparticle toolkit is presented development mRNA-based therapeutics from perspective. Nano-delivery derived either natural or chemical synthesis, nature organic inorganic materials, are summarised. Delivery strategies controlling tissue targeting release, role nanoparticles building boosting activity drugs, have also been introduced. end, our insights into clinical translational nano-drugs presented.

Language: Английский

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Inorganic nanoparticles in dermopharmaceutical and cosmetic products: Properties, formulation development, toxicity, and regulatory issues

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2023, Volume and Issue: 192, P. 25 - 40

Published: Sept. 20, 2023

The use of nanotechnology strategies is a current hot topic, and research in this field has been growing significantly the cosmetics industry. Inorganic nanoparticles stand out context for their distinctive physicochemical properties, leading particular to an increased refractive index absorption capacity giving them broad potential cutaneous applications making special interest dermopharmaceutical cosmetic purposes. This performance responsible its heavy inclusion manufacture skin health products such as sunscreens, lotions, beauty creams, ointments, makeup, others. In particular, suitable bandgap energy characteristics allow be used photocatalytic semiconductors. They provide excellent UV absorption, commonly known filters, are wide worldwide sunscreen formulations without undesirable white residue after consumer application. addition, based on inorganic have several additional relevant formulation development, being less expensive compared other nanomaterials, having greater stability, ensuring irritation, itching, propensity allergies. review will address detail main products, titanium dioxide, zinc oxide, silicon silver, gold, copper, aluminum nanoparticles, nanocrystals, quantum dots, reporting characteristics, but also intrinsic properties that contribute type formulations. Safety issues regarding toxicity studies, both humans environment, well regulatory affairs associated with dermopharmaceuticals cosmetics, addressed.

Language: Английский

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