ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Spinal
cord
injury
(SCI)
remains
a
formidable
challenge
in
biomedical
research,
as
the
silencing
of
intrinsic
regenerative
signals
most
spinal
neurons
results
an
inability
to
reestablish
neural
circuits.
In
this
study,
we
found
that
with
low
axonal
regeneration
after
SCI
showed
decreased
extracellular
signal-regulated
kinase
(ERK)
phosphorylation
levels.
However,
expression
dual
specificity
phosphatase
26
(DUSP26)─which
negatively
regulates
ERK
phosphorylation─was
reduced
considerably
undergoing
spontaneous
regeneration.
Therefore,
developed
system
named
F10@MS@UV-HG
integrated
DUSP26-specific
inhibitor
into
reactive
oxygen
species-responsive
nanoparticles
and
embedded
them
photosensitive
hydrogels.
This
effectively
downregulated
DUSP26
primary
enhanced
phosphorylation,
ultimately
promoting
outgrowth.
When
transplanted
mouse
model,
achieved
sustained
drug
release,
specifically
targeting
DUSP26/ERK/ELK1
pathway
facilitating
short-term
Additionally,
long-term
repair
effects─including
improved
myelination
motor
function─were
evident
mice
F10@MS@UV-HG.
The
suggested
activating
signaling
by
modulating
could
promote
functional
recovery.
Thus,
exhibits
enormous
potential
therapeutic
approach
for
patients
SCI.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
201, P. 107086 - 107086
Published: Jan. 29, 2024
The
progress
in
human
disease
treatment
can
be
greatly
advanced
through
the
implementation
of
nanomedicine.
This
approach
involves
targeted
and
cell-specific
therapy,
controlled
drug
release,
personalized
dosage
forms,
wearable
delivery,
companion
diagnostics.
By
integrating
cutting-edge
technologies
with
delivery
systems,
greater
precision
achieved
at
tissue
cellular
levels
use
stimuli-responsive
nanoparticles,
development
electrochemical
sensor
systems.
targeting
–
by
virtue
nanotechnology
allows
for
therapy
to
directed
specifically
affected
tissues
while
reducing
side
effects
on
healthy
tissues.
As
such,
nanomedicine
has
potential
transform
conditions
such
as
cancer,
genetic
diseases,
chronic
illnesses
facilitating
precise
delivery.
Additionally,
forms
devices
offer
ability
tailor
unique
needs
each
patient,
thereby
increasing
therapeutic
effectiveness
compliance.
Companion
diagnostics
further
enable
efficient
monitoring
response,
enabling
customized
adjustments
plan.
question
whether
all
approaches
outlined
here
are
viable
alternatives
current
treatments
is
also
discussed.
In
general,
application
field
biomedicine
may
provide
a
strong
alternative
existing
several
reasons.
this
review,
we
aim
present
evidence
that,
although
early
stages,
fully
merging
technology
innovative
shows
promise
successful
across
various
areas,
including
cancer
or
diseases.
Progress in Materials Science,
Journal Year:
2024,
Volume and Issue:
146, P. 101314 - 101314
Published: June 3, 2024
This
review
offers
a
comprehensive
evaluation
of
an
emerging
category
adsorbing
materials
known
as
high
surface
area
(HSAMs)
in
the
realm
water
remediation.
The
objective
is
to
shed
light
on
recent
advancements
HSAMs
featuring
multiple
dimensionalities,
addressing
their
efficacy
toxic
metal
ions
from
wastewater.
spectrum
examined
this
encompasses
metal–organic
frameworks
(MOFs),
covalent
organic
(COFs),
carbon-based
porous
materials,
mesoporous
silica,
polymer-based
layered
double
hydroxides,
and
aerogels.
delves
into
state-of-the-art
design
synthetic
approaches
for
these
elucidating
inherent
properties.
It
particularly
emphasizes
how
combination
pore
structure
contributes
effectiveness
ions.
These
possess
remarkable
attributes,
including
molecular
functionalization
versatility,
porosity,
expansive
area,
distinctive
physicochemical
characteristics,
well-defined
crystal
structures,
rendering
them
exceptional
adsorbents.
While
each
boasts
unique
advantages
stemming
properties,
synthesis
often
entails
intricate
costly
procedures,
presenting
substantial
obstacle
commercialization
widespread
adoption.
Finally,
underscores
existing
challenges
that
must
be
addressed
expedite
translation
remediation
applications
promising
materials.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
Science Progress,
Journal Year:
2024,
Volume and Issue:
107(4)
Published: Oct. 1, 2024
The
incidence
of
cancer
is
increasing
and
evolving
as
a
major
source
mortality.
Nanotechnology
has
garnered
considerable
scientific
interest
in
recent
decades
can
offer
promising
solution
to
the
challenges
encountered
with
traditional
chemotherapy.
Nanoparticle
utilization
holds
promise
combating
other
diseases,
offering
exciting
prospects
for
drug
delivery
systems
medicinal
applications.
Metallic
nanoparticles
exhibit
remarkable
physical
chemical
properties,
such
their
minute
size,
composition,
structure,
extensive
surface
area,
rendering
them
versatile
cost-effective.
Research
demonstrated
significant
beneficial
impact
on
treatment,
characterized
by
enhanced
targeting
abilities,
gene
activity
suppression,
improved
efficiency.
By
incorporating
ligands,
functionalized
metal
ensure
precise
energy
deposition
within
tumors,
thereby
augmenting
treatment
accuracy.
Moreover,
beyond
therapeutic
efficacy,
serve
valuable
tools
cell
visualization,
contributing
diagnostic
techniques.
Utilizing
allows
simultaneous
diagnosis
while
also
facilitating
controlled
release,
thus
revolutionizing
care.
This
narrative
review
investigates
advancements
types
mechanisms
cells,
application
clinical
scenarios,
potential
toxicity
medicine.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(29), P. 19283 - 19302
Published: July 11, 2024
Developing
strategies
to
target
injured
pancreatic
acinar
cells
(PACs)
in
conjunction
with
primary
pathophysiology-specific
pharmacological
therapy
presents
a
challenge
the
management
of
acute
pancreatitis
(AP).
We
designed
and
synthesized
trypsin-cleavable
organosilica
precursor
bridged
by
arginine-based
amide
bonds,
leveraging
trypsin's
ability
selectively
identify
guanidino
groups
on
arginine
via
Asp189
at
active
S1
pocket
cleave
carboxy-terminal
(C-terminal)
bond
catalytic
triads.
The
precursors
were
incorporated
into
framework
mesoporous
silica
nanoparticles
(MSNs)
for
encapsulating
membrane-permeable
Ca
