Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

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Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)

Published: Dec. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Language: Английский

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Nanozymes: Definition, Activity, and Mechanisms

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 17, 2023

Abstract “Nanozyme” is used to describe various catalysts from immobilized inorganic metal complexes, enzymes nanoparticles. Here, the history of nanozymes dvescribed in detail, and they can be largely separated into two types. Type 1 refer or on nanomaterials, which were dominant first decade since 2004. 2 nanozymes, rely surface catalytic properties are dominating type past decade. The definition evolving, a based same substrates products as able cover most currently claimed although may have different mechanisms compared their enzyme counterparts. A broader inspire application‐based research replace with nanomaterials for analytical, environmental, biomedical applications. Comparison also requires clear nanozyme unit. Four ways defining unit described, iron oxide horseradish peroxidase activity comparison examples each definition. Growing work devoted understanding mechanism provides basis further rational engineering active sites. Finally, future perspective field discussed.

Language: Английский

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Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 12, 2022

As pioneering Fe

Language: Английский

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A Bioinspired Five‐Coordinated Single‐Atom Iron Nanozyme for Tumor Catalytic Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(15)

Published: Feb. 1, 2022

Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic geometric structures are essential for maximizing their enzyme-like catalytic activity therapeutic efficacy but remain challenging. Here, melamine-mediated pyrolysis activation strategy is reported fabrication iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron microscopy imaging X-ray absorption fine analyses. FeN5 exhibits superior peroxidase-like owing to optimized coordination structure, corresponding efficiency Fe-species 7.64 3.45 × 105 times higher than those traditional FeN4 Fe3 O4 nanozyme, respectively, demonstrated steady-state kinetic assay. In addition, mechanism jointly disclosed experimental results density functional theory studies. as-synthesized demonstrates significantly enhanced antitumor effect vitro vivo due excellent under tumor microenvironment.

Language: Английский

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Nanozyme-Enabled Analytical Chemistry

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 94(1), P. 312 - 323

Published: Dec. 6, 2021

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNanozyme-Enabled Analytical ChemistrySirong LiSirong LiDepartment of Biomedical Engineering, College Engineering and Applied Sciences, Nanjing National Laboratory Microstructures, Jiangsu Key Artificial Functional Materials, University, Nanjing, 210023, ChinaMore by Sirong LiView Biography, Yihong ZhangYihong ZhangState Chemistry for Life Science, School Chemical Biomedicine Innovation Center (ChemBIC), ZhangView Quan WangQuan WangDepartment WangView Anqi LinAnqi LinDepartment LinView Hui Wei*Hui WeiDepartment ChinaState China*E-mail: [email protected]More WeiView Biographyhttps://orcid.org/0000-0003-0870-7142Cite this: Anal. Chem. 2022, 94, 1, 312–323Publication Date (Web):December 6, 2021Publication History Published online6 December 2021Published inissue 11 January 2022https://pubs.acs.org/doi/10.1021/acs.analchem.1c04492https://doi.org/10.1021/acs.analchem.1c04492review-articleACS PublicationsCopyright © 2021 American SocietyRequest reuse permissionsArticle Views8121Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting SUBJECTS:Carbohydrates,Chemical specificity,Enzyme-linked immunosorbent assays,Metal organic frameworks,Peptides proteins Get e-Alerts

Language: Английский

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Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

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Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 12, 2022

Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but limited by insufficient non-selective activities. Herein, we developed single-atom of RhN

Language: Английский

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Defect engineering in nanozymes

Materials Today, Journal Year: 2021, Volume and Issue: 52, P. 327 - 347

Published: Nov. 29, 2021

Language: Английский

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Edge‐Site Engineering of Defective Fe–N₄ Nanozymes with Boosted Catalase‐Like Performance for Retinal Vasculopathies

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(39)

Published: Aug. 12, 2022

Extensive efforts are devoted to refining metal sites for optimizing the catalytic performance of single-atom nanozymes (SANzymes), while contribution defect environment neighboring lacks attention. Herein, an iron-based SANzyme (Fe-SANzyme) is rationally designed by edge-site engineering, which intensively exposes edge-hosted defective Fe-N4 atomic anchored in hierarchical mesoporous structures. The Fe-SANzyme exhibits excellent catalase-like activity capable efficiently catalyzing decomposition H2 O2 into and O, with a kinetic KM value superior that natural catalase reported nanozymes. mechanistic studies depict defects introduce notable charge transfer from Fe atom carbon matrix, making central more activated strengthen interaction weaken OO bond. By performing catalysis, significantly scavenges reactive oxygen species (ROS) alleviates oxidative stress, thus eliminating pathological angiogenesis animal models retinal vasculopathies without affecting repair normal vessels. This work provides new way refine SANzymes engineering geometric structure around sites, demonstrates potential therapeutic effects nanozyme on vasculopathies.

Language: Английский

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