Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 12, 2022

As pioneering Fe

Language: Английский

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Tumor‐Microenvironment‐Responsive Cascade Reactions by a Cobalt‐Single‐Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(48)

Published: Aug. 16, 2022

Nanocatalytic therapy, involving the nanozyme-triggered production of reactive oxygen species (ROS) in tumor microenvironment (TME), has demonstrated potential but nanozymes still face challenges activity and specificity that compromise therapeutic efficacy. Herein, we report a strategy based on single-atom nanozyme to initiate cascade enzymatic reactions TME for tumor-specific treatment. The cobalt-single-atom nanozyme, with Co-N coordination N-doped porous carbon (Co-SAs@NC), displays catalase-like decomposes cellular endogenous H2 O2 produce , subsequent oxidase-like converts into cytotoxic superoxide radicals efficiently kill cells. By incorporation doxorubicin, therapy achieves significantly enhanced antitumor effect vivo. Our findings show TME-specific catalytic combined chemotherapy is promising efficient therapy.

Language: Английский

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Edge‐Site Engineering of Defective Fe–N₄ Nanozymes with Boosted Catalase‐Like Performance for Retinal Vasculopathies

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(39)

Published: Aug. 12, 2022

Extensive efforts are devoted to refining metal sites for optimizing the catalytic performance of single-atom nanozymes (SANzymes), while contribution defect environment neighboring lacks attention. Herein, an iron-based SANzyme (Fe-SANzyme) is rationally designed by edge-site engineering, which intensively exposes edge-hosted defective Fe-N4 atomic anchored in hierarchical mesoporous structures. The Fe-SANzyme exhibits excellent catalase-like activity capable efficiently catalyzing decomposition H2 O2 into and O, with a kinetic KM value superior that natural catalase reported nanozymes. mechanistic studies depict defects introduce notable charge transfer from Fe atom carbon matrix, making central more activated strengthen interaction weaken OO bond. By performing catalysis, significantly scavenges reactive oxygen species (ROS) alleviates oxidative stress, thus eliminating pathological angiogenesis animal models retinal vasculopathies without affecting repair normal vessels. This work provides new way refine SANzymes engineering geometric structure around sites, demonstrates potential therapeutic effects nanozyme on vasculopathies.

Language: Английский

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Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 11, 2023

Nanozymes, a class of nanomaterials mimicking the function enzymes, have aroused much attention as candidate in diverse fields with arbitrarily tunable features owing to diversity crystalline nanostructures, composition, and surface configurations. However, uncertainty their active sites lower intrinsic deficiencies nanomaterial-initiated catalysis compared natural enzymes promote pursuing alternatives by imitating biological centers. Single-atom nanozymes (SAzymes) maximize atom utilization well-defined structure, providing an important bridge investigate mechanism relationship between structure catalytic activity. They risen new burgeoning alternative enzyme from vitro bioanalytical tool vivo therapy flexible atomic engineering structure. Here, focus is mainly on three parts. First, detailed overview single-atom catalyst synthesis strategies including bottom-up top-down approaches given. Then, according structural feature nanocatalysts, influence factors such central metal atom, coordination number, heteroatom doping, metal-support interaction are discussed representative applications (including antibacterial/antiviral performance, cancer therapy, biosensing) highlighted. In end, future perspective challenge facing demonstrated.

Language: Английский

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Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214896 - 214896

Published: Oct. 27, 2022

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Dimensionality Engineering of Single-Atom Nanozyme for Efficient Peroxidase-Mimicking

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(30), P. 16835 - 16842

Published: July 24, 2023

In nature, enzymatic reactions occur in well-functioning catalytic pockets, where substrates bind and react by properly arranging the sites amino acids a three-dimensional (3D) space. Single-atom nanozymes (SAzymes) are new type of with active similar to those natural metalloenzymes. However, centers current SAzymes two-dimensional (2D) architectures lack collaborative substrate-binding features limits their activity. Herein, we report dimensionality engineering strategy convert conventional 2D Fe–N-4 into 3D structures integrating oxidized sulfur functionalities onto carbon plane. Our results suggest that could serve as binding for assisting substrate orientation facilitating desorption H2O, resulting an outstanding specific activity up 119.77 U mg–1, which is 6.8 times higher than FeN4C SAzymes. This study paves way rational design highly single-atom nanozymes.

Language: Английский

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A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(11)

Published: Dec. 31, 2022

Abstract The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated therapy. Since electron transfer is basic essence catalysis‐mediated redox reactions, we explored contributing factors enzymatic based on positive negative charges, which experimentally theoretically demonstrated to enhance peroxidase (POD)‐like a MoS nanozyme. Hence, an acidic microenvironment‐responsive ultrasound‐mediated cascade nanocatalyst (BTO/MoS @CA) presented that made from few‐layer nanosheets grown surface piezoelectric tetragonal barium titanate (T‐BTO) modified with pH‐responsive cinnamaldehyde (CA). integration CA‐mediated self‐supply, charge‐enhanced activity, glutathione (GSH) depletion enables out‐of‐balance homeostasis, leading effective ferroptosis minimal side effects.

Language: Английский

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